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Author (up) Pontremoli, C.; Forni, D.; Sironi, M. url  doi
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  Title Arenavirus genomics: novel insights into viral diversity, origin, and evolution Type Journal Article
  Year 2019 Publication Current Opinion in Virology Abbreviated Journal Curr Opin Virol  
  Volume 34 Issue Pages 18-28  
  Keywords Animals; Arenaviridae Infections/transmission; Arenavirus/*genetics; *Evolution, Molecular; Fishes/virology; *Genetic Variation; *Genome, Viral; High-Throughput Nucleotide Sequencing; Host Microbial Interactions; Humans; Reptiles/virology; Zoonoses/transmission/virology  
  Abstract Next-generation sequencing technologies have revolutionized our knowledge of virus diversity and evolution. In the case of arenaviruses, which are the focus of this review, metagenomic/metatranscriptomic approaches identified reptile-infecting and fish-infecting viruses, also showing that bi-segmented genomes are not a universal feature of the Arenaviridae family. Novel mammarenaviruses were described, allowing inference of their geographic origin and evolutionary dynamics. Extensive sequencing of Lassa virus (LASV) genomes revealed the zoonotic nature of most human infections and a Nigerian origin of LASV, which subsequently spread westward. Future efforts will likely identify many more arenaviruses and hopefully provide insight into the ultimate origin of the family, the pathogenic potential of its members, as well as the determinants of their geographic distribution.  
  Address Scientific Institute, IRCCS E. MEDEA, Bioinformatics, 23842 Bosisio Parini, Lecco, Italy. Electronic address: manuela.sironi@bp.lnf.it  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1879-6257 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30497052 Approved no  
  Call Number Medea @ manuela.sironi @ Serial 46103  
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