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Author (up) Saito, Y.; Komatsu, K. openurl 
  Title Functional Role of NBS1 in Radiation Damage Response and Translesion DNA Synthesis Type Journal Article
  Year 2015 Publication Abbreviated Journal Biomolecules  
  Volume 5 Issue 3 Pages 1990--2002  
  Keywords chemistry,metabolism; Chromatin Assembly and Disassembly,drug effects,radiation effects; DNA,biosynthesis,genetics; DNA Damage; Homologous Recombination,radiation effects; Humans; Nuclear Proteins,metabolism; Radiation; DNA repair; NBS1; chromatin remodeling; homologous recombination; translesion DNA synthesis  
  Abstract Nijmegen breakage syndrome (NBS) is a recessive genetic disorder characterized by increased sensitivity to ionizing radiation (IR) and a high frequency of malignancies. NBS1, a product of the mutated gene in NBS, contains several protein interaction domains in the N-terminus and C-terminus. The C-terminus of NBS1 is essential for interactions with MRE11, a homologous recombination repair nuclease, and ATM, a key player in signal transduction after the generation of DNA double-strand breaks (DSBs), which is induced by IR. Moreover, NBS1 regulates chromatin remodeling during DSB repair by histone H2B ubiquitination through binding to RNF20 at the C-terminus. Thus, NBS1 is considered as the first protein to be recruited to DSB sites, wherein it acts as a sensor or mediator of DSB damage responses. In addition to DSB response, we showed that NBS1 initiates Polη-dependent translesion DNA synthesis by recruiting RAD18 through its binding at the NBS1 C-terminus after UV exposure, and it also functions after the generation of interstrand crosslink DNA damage. Thus, NBS1 has multifunctional roles in response to DNA damage from a variety of genotoxic agents, including IR.  
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  Series Volume Series Issue Edition  
  ISSN 2218-273x ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number AG @ matthewjvarga @ Serial 47070  
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