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Author Dinesh, K.P.; Vijayakumar, S.P.; Channakeshavamurthy, B.H.; Torsekar, V.A.R.U.N.R.; Kulkarni, N.I.R.M.A.L.U.; Shanker, K.A.R.T.I.K. openurl 
  Title Erratum: KP DINESH, SP VIJAYAKUMAR, BH CHANNAKESHAVAMURTHY, VARUN R. TORSEKAR, NIRMAL U. KULKARNI & KARTIK SHANKER (2015) SYSTEMATIC STATUS OF FEJERVARYA (AMPHIBIA, ANURA, DICROGLOSSIDAE) FROM SOUTH AND SE ASIA WITH THE DESCRIPTION OF A NEW SPECIES FROM THE WESTERN GHATS OF PENINSULAR INDIA. Zootaxa, 3999 (1): 079-094 Type Journal Article
  Year 2015 Publication Abbreviated Journal (down) Zootaxa  
  Volume 4033 Issue 4 Pages 600  
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  ISSN 1175-5334 ISBN Medium  
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  Notes Approved no  
  Call Number CES @ dilipnaidu.gt @ Serial 42980  
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Author Datta-Roy, A.; Deepak, V.; Sidharthan, C.; Barley, A.J.; Praveen, K. openurl 
  Title An addition to the endemic Indian radiation of Eutropis: Phylogenetic position of Eutropis dissimilis Hallowell (Squamata: Scincidae) Type Journal Article
  Year 2015 Publication Abbreviated Journal (down) Zootaxa  
  Volume 4027 Issue 1 Pages 145-150  
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  ISSN 1175-5334 ISBN Medium  
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  Notes Approved no  
  Call Number CES @ dilipnaidu.gt @ Serial 43106  
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Author Dinesh, K.P.; Vijayakumar, S.P.; Channakeshavamurthy, B.H.; Toreskar, V.R.; Kulkarni, N.U.; Shanker, K. openurl 
  Title Systematic status of Fejervarya (Amphibia, Anura, Dicroglossidae) from South and SE Asia with the description of a new species from the Western Ghats of Peninsular India Type Journal Article
  Year 2015 Publication Abbreviated Journal (down) Zootaxa  
  Volume 3999 Issue 1 Pages 079-094  
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  Call Number CES @ dilipnaidu.gt @ Serial 43132  
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Author Kadiyska, T.; Nossikoff, A. url  openurl
  Title Stool DNA methylation assays in colorectal cancer screening Type Journal Article
  Year 2015 Publication Abbreviated Journal (down) World J Gastroenterol  
  Volume 21 Issue 35 Pages 10057-10061  
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  Abstract Colorectal cancer (CRC) is fourth most common cancer in men and third in women worldwide. Developing a diagnostic panel of sensitive and specific biomarkers for the early detection of CRC is recognised as to be crucial for early initial diagnosis, which in turn leads to better long term survival. Most of the research on novel potential CRC biomarkers in the last 2 decades has been focussed on stool DNA analysis. In this paper, we describe the recent advances in non-invasive CRC screening and more specifically in molecular assays for aberrantly methylated BMP3 and NDRG4 promoter regions. In several research papers these markers showed superior rates for sensitivity and specificity in comparison to previously described assays. These tests detected the majority of adenomas ≥ 1 cm in size and the detection rates progressively increased with larger adenomas. The methylation status of the BMP3 and NDRG4 promoters demonstrated effective detection of neoplasms at all sites throughout the colon and was not affected by common clinical variables. Recently, a multitarget stool DNA test consisting of molecular assays for aberrantly methylated BMP3 and NDRG4 promoter regions, mutant KRAS and immunochemical assay for human haemoglobin has been made commercially available and is currently reimbursed in the United States. Although this is the most sensitive non-invasive CRC screening test, there is the need for further research in several areas – establishment of the best timeframe for repeated DNA stool testing; validation of the results in populations outside of North America; usefulness for surveillance and prognosis of patients; cost-effectiveness of DNA stool testing in real-life populations.  
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  Call Number UofT @ ankit.sinha @ Serial 45144  
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Author Deepak, V.; Vyas, R.; Giri, V.B.; Karanth, K.P. openurl 
  Title A taxonomic mystery for more than 180 years: the identity and systematic position of Brachysaura minor (HARDWICKE & GRAY, 1827) Type Journal Article
  Year 2015 Publication Abbreviated Journal (down) Vertebrate Zoology  
  Volume 65 Issue 3 Pages 371-381  
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  ISSN 1864-5755 ISBN Medium  
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  Call Number CES @ dilipnaidu.gt @ Serial 43033  
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Author Ray, R.; Chandran, M.D.S.; Ramachandra, T.V. openurl 
  Title Hydrological importance of sacred forest fragments in Central Western Ghats of India Type Journal Article
  Year 2015 Publication Abbreviated Journal (down) Tropical Ecology  
  Volume 56 Issue 1 Pages 87-99  
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  ISSN 0564-3295 ISBN Medium  
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  Call Number CES @ dilipnaidu.gt @ Serial 42956  
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Author Alkuraya, F.S. url  openurl
  Title Human knockout research: new horizons and opportunities Type Journal Article
  Year 2015 Publication Abbreviated Journal (down) Trends Genet  
  Volume 31 Issue 2 Pages 108-115  
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  Abstract Although numerous approaches have been pursued to understand the function of human genes, Mendelian genetics has by far provided the most compelling and medically actionable dataset. Biallelic loss-of-function (LOF) mutations are observed in the majority of autosomal recessive Mendelian disorders, representing natural human knockouts and offering a unique opportunity to study the physiological and developmental context of these genes. The restriction of such context to ‘disease’ states is artificial, however, and the recent ability to survey entire human genomes for biallelic LOF mutations has revealed a surprising landscape of knockout events in ‘healthy’ individuals, sparking interest in their role in phenotypic diversity beyond disease causation. As I discuss in this review, the potentially wide implications of human knockout research warrant increased investment and multidisciplinary collaborations to overcome existing challenges and reap its benefits.  
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  ISSN 0168-9525 ISBN Medium  
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  Call Number UofT @ mathieu.lemaire @ Serial 45506  
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Author Andersson, R.; Sandelin, A.; Danko, C.G. url  openurl
  Title A unified architecture of transcriptional regulatory elements Type Journal Article
  Year 2015 Publication Abbreviated Journal (down) Trends Genet  
  Volume 31 Issue 8 Pages 426-433  
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  Abstract Gene expression is precisely controlled in time and space through the integration of signals that act at gene promoters and gene-distal enhancers. Classically, promoters and enhancers are considered separate classes of regulatory elements, often distinguished by histone modifications. However, recent studies have revealed broad similarities between enhancers and promoters, blurring the distinction: active enhancers often initiate transcription, and some gene promoters have the potential to enhance transcriptional output of other promoters. Here, we propose a model in which promoters and enhancers are considered a single class of functional element, with a unified architecture for transcription initiation. The context of interacting regulatory elements and the surrounding sequences determine local transcriptional output as well as the enhancer and promoter activities of individual elements.  
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  ISSN 0168-9525 ISBN Medium  
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  Call Number UofT @ mathieu.lemaire @ Serial 45626  
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Author Hasan, N.; Ohman, A.W.; Dinulescu, D.M. url  openurl
  Title The promise and challenge of ovarian cancer models Type Journal Article
  Year 2015 Publication Abbreviated Journal (down) Transl Cancer Res  
  Volume 4 Issue 1 Pages 14-28  
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  Abstract The complexity and heterogeneity of ovarian cancer cases are difficult to reproduce in in vitro studies, which cannot adequately elucidate the molecular events involved in tumor initiation and disease metastasis. It has now become clear that, although the multiple histological subtypes of ovarian cancer are being treated with similar surgical and therapeutic approaches, they are in fact characterized by distinct phenotypes, cell of origin, and underlying key genetic and genomic alterations. Consequently, the development of more personalized treatment methodologies, which are aimed at improving patient care and prognosis, will greatly benefit from a better understanding of the key differences between various subtypes. To accomplish this, animal models of all histotypes need to be generated in order to provide accurate in vivo platforms for research and the testing of targeted treatments and immune therapies. Both genetically engineered mouse models (GEMMs) and xenograft models have the ability to further our understanding of key mechanisms facilitating tumorigenesis, and at the same time offer insight into enhanced imaging and treatment modalities. While genetic models may be better suited to examine oncogenic functions and interactions during tumorigenesis, patient-derived xenografts (PDXs) are likely a superior model to assess drug efficacy, especially in concurrent clinical trials, due to their similarity to the tumors from which they are derived. Genetic and avatar models possess great clinical utility and have both benefits and limitations. Additionally, the laying hen model, which spontaneously develops ovarian tumors, has inherent advantages for the study of epithelial ovarian cancer (EOC) and recent work champions this model especially when assessing chemoprevention strategies. While high-grade ovarian serous tumors are the most prevalent form of EOC, rarer ovarian cancer variants, such as small cell ovarian carcinoma of the hypercalcemic type and transitional cell carcinoma, or non-epithelial tumors, including germ cell tumors, will also benefit from the generation of improved models to advance our understanding of tumorigenic mechanisms and the development of selective therapeutic options.  
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  Call Number UofT @ ankit.sinha @ Serial 45119  
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Author Chiolerio, A.; Bocchini, S.; Scaravaggi, F.; Porro, S.; Perrone, D.; Beretta, D.; Caironi, M.; Fabrizio Pirri, C. url  openurl
  Title Synthesis of polyaniline-based inks for inkjet printed devices: Electrical characterization highlighting the effect of primary and secondary doping Type Journal Article
  Year 2015 Publication Abbreviated Journal (down) Semiconductor Science and Technology  
  Volume 30 Issue 10 Pages  
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  Notes Cited By :4; Export Date: 2 November 2016 Approved no  
  Call Number IIT-CSF @ alessandro.chiolerio @ Serial 42777  
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