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Author Ariceta, G.; Lara, E.; Camacho, J.A.; Oppenheimer, F.; Vara, J.; Santos, F.; Muñoz, M.A.; Cantarell, C.; Gil Calvo, M.; Romero, R.; Valenciano, B.; García-Nieto, V.; Sanahuja, M.J.; Crespo, J.; Justa, M.L.; Urisarri, A.; Bedoya, R.; Bueno, A.; Daza, A.; Bravo, J.; Llamas, F.; Jiménez Del Cerro, L.A. url  openurl
  Title Cysteamine (Cystagon®) adherence in patients with cystinosis in Spain: successful in children and a challenge in adolescents and adults Type Journal Article
  Year 2015 Publication Abbreviated Journal Nephrol Dial Transplant  
  Volume 30 Issue 3 Pages 475-480  
  Keywords  
  Abstract BACKGROUND: Cysteamine has improved survival and prognosis in cystinosis. Increasing numbers of patients reach adulthood and face new challenges such as compliance that wanes over time. The aim of this study was to evaluate adherence to cysteamine treatment in a group of cystinotic patients in Spain in an attempt to identify potential therapy pitfalls and improve the overall care of affected individuals. Despite the impact of cysteamine on prognosis, there is a paucity of data regarding adherence. METHOD: Thirty-four cystinotic patients (21 male) 38% ≥18 years were enrolled in a voluntary, anonymous survey. Replies were obtained from patients (15/34), mothers (11/34), fathers (4/34) and both parents (4/34). RESULTS: Patient age (median and interquartile range) at diagnosis was 1 year (0.57-1), and patient age at Cystagon® initiation was also 1 year (0.8-1.8). Sixteen (47%) were kidney transplant (KTx) recipients; six were retransplanted. Age at first KTx 10 years (8.7-13.7). Patient understanding of multiorgan involvement in cystinosis: 4.1 organs reported; eye 97% and kidney 91%. Cysteamine was given by mother (100%) and father (83%) in <11 year olds, or self-administered (94%) in ≥11 year olds. Four daily doses in 89% versus 56% in <11 year olds or ≥11 year olds, with fixed schedule in 94% versus 50% in <11 or ≥11 year olds and progressive loss of reminders over time. Furthermore, 44% complained of unpleasant smell. Motivation for treatment compliance was 100% versus 40% in <11 versus ≥11 year olds, respectively. Disease impact in patients <18 years is as follows: school (29%), social (14%), ‘feeling different’ (10%); in patients ≥18 years: ‘feeling different’ (62%), professional (39%) and job absenteeism (31%). Referring physician: paediatric nephrologist (94%) and nephrologist (63%) in <11 versus ≥11 year olds. Ophthalmological follow-up: 83% versus 38% in <11 versus ≥11 year olds. Patient opinion of physician expertise: paediatric nephrologist (94%) and nephrologist (44%). New treatment options (65%) and better information (42%) were demanded to improve adherence. CONCLUSION: Treatment with Cystagon is effective in young patients. However, adherence diminishes over time in adolescents and adults despite disease impact. Strategies such as better information on the disease, patient self-care promotion and facilitated transition to adult healthcare services are required to improve compliance and the clinical management of cystinosis.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0931-0509 ISBN Medium  
  Area Expedition Conference  
  Notes Approved (up) no  
  Call Number UofT @ mathieu.lemaire @ Serial 45856  
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Author Aichler, M.; Walch, A. url  openurl
  Title MALDI Imaging mass spectrometry: current frontiers and perspectives in pathology research and practice Type Journal Article
  Year 2015 Publication Abbreviated Journal Lab Invest  
  Volume 95 Issue 4 Pages 422-431  
  Keywords  
  Abstract MALDI Imaging mass spectrometry has entered the field of tissue-based research by providing unique advantages for analyzing tissue specimen in an unprecedented detail. A broad spectrum of analytes ranging from proteins, peptides, protein modification over small molecules, drugs and their metabolites as well as pharmaceutical components, endogenous cell metabolites, lipids, and other analytes are made accessible by this in situ technique in tissue. Some of them were even not accessible in tissues within the histological context before. Thereby, the great advantage of MALDI Imaging is the correlation of molecular information with traditional histology by keeping the spatial localization information of the analytes after mass spectrometric measurement. This method is label-free and allows multiplex analysis of hundreds to thousands of molecules in the very same tissue section simultaneously. Imaging mass spectrometry brings a new quality of molecular data and links the expert discipline of pathology and deep molecular mass spectrometric analysis to tissue-based research. This review will focus on state-of-the-art of MALDI Imaging mass spectrometry, its recent applications by analyzing tissue specimen and the contributions in understanding the biology of disease as well as its perspectives for pathology research and practice.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0023-6837 ISBN Medium  
  Area Expedition Conference  
  Notes Approved (up) no  
  Call Number UofT @ mathieu.lemaire @ Serial 45924  
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Author isbn  openurl
  Title Mechanobiology of the Endothelium Type Book Whole
  Year 2015 Publication Abbreviated Journal  
  Volume Issue Pages  
  Keywords  
  Abstract The endothelium is an excellent example of where biology meets physics and engineering. It must convert mechanical forces into chemical signals to maintain homeostasis. It also controls the immune response, drug delivery through the vasculature, and cancer metastasis. Basic understanding of these processes is starting to emerge and the knowledge gained from research is now being used in applications from drug delivery to imaging modalities. This book reviews current knowledge in mechanobiology of the endothelium and its implications for the development of theranostic devices.  
  Address  
  Corporate Author Thesis  
  Publisher CRC Press Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN 9781482207255 Medium  
  Area Expedition Conference  
  Notes Approved (up) no  
  Call Number UofT @ mathieu.lemaire @ Serial 45932  
Permanent link to this record
 

 
Author Aiff, H.; Attman, P.O.; Aurell, M.; Bendz, H.; Ramsauer, B.; Schön, S.; Svedlund, J. url  openurl
  Title Effects of 10 to 30 years of lithium treatment on kidney function Type Journal Article
  Year 2015 Publication Abbreviated Journal J Psychopharmacol  
  Volume 29 Issue 5 Pages 608-614  
  Keywords  
  Abstract Long-term lithium treatment is associated with end-stage renal disease, but there is little evidence of a clinically significant reduction in renal function in most patients. We previously found that 1.5% of people who took lithium from the 1960s and 1970s developed end-stage renal disease; however, none of the patients who started after 1980 had end-stage renal disease. Here we aimed to study the prevalence and extent of kidney damage during the course of long-term lithium treatment since 1980. We retrieved serum lithium and creatinine levels from 4879 patients examined between 1 January 1981 and 31 December 2010. Only patients who started their lithium treatment during the study period and had at least 10 years of cumulative treatment were included. The study group comprised 630 adult patients (402 women and 228 men) with normal creatinine levels at the start of lithium treatment. There was a yearly increase in median serum creatinine levels already from the first year of treatment. About one-third of the patients who had taken lithium for 10-29 years had evidence of chronic renal failure but only 5% were in the severe or very severe category. The results indicate that a substantial proportion of adult patients who are treated with lithium for more than a decade develop signs of renal functional impairment, also when treated according to modern therapeutic principles. Our results emphasise that lithium treatment requires continuous monitoring of kidney function.  
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  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0269-8811 ISBN Medium  
  Area Expedition Conference  
  Notes Approved (up) no  
  Call Number UofT @ mathieu.lemaire @ Serial 45943  
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Author Andeen, N.K.; Nguyen, T.Q.; Steegh, F.; Hudkins, K.L.; Najafian, B.; Alpers, C.E. url  openurl
  Title The phenotypes of podocytes and parietal epithelial cells may overlap in diabetic nephropathy Type Journal Article
  Year 2015 Publication Abbreviated Journal Kidney Int  
  Volume 88 Issue 5 Pages 1099-1107  
  Keywords  
  Abstract Reversal of diabetic nephropathy (DN) has been achieved in humans and mice, but only rarely and under special circumstances. As progression of DN is related to podocyte loss, reversal of DN requires restoration of podocytes. Here, we identified and quantified potential glomerular progenitor cells that could be a source for restored podocytes. DN was identified in 31 human renal biopsy cases and separated into morphologically early or advanced lesions. Markers of podocytes (WT-1, p57), parietal epithelial cells (PECs) (claudin-1), and cell proliferation (Ki-67) were identified by immunohistochemistry. Podocyte density was progressively reduced with DN. Cells marking as podocytes (p57) were present infrequently on Bowman’s capsule in controls, but significantly increased in histologically early DN. Ki-67-expressing cells were identified on the glomerular tuft and Bowman’s capsule in DN, but rarely in controls. Cells marking as PECs were present on the glomerular tuft, particularly in morphologically advanced DN. These findings show evidence of phenotypic plasticity in podocyte and PEC populations and are consistent with studies in the BTBR ob/ob murine model in which reversibility of DN occurs with podocytes potentially regenerating from PEC precursors. Thus, our findings support, but do not prove, that podocytes may regenerate from PEC progenitors in human DN. If so, progression of DN may represent a modifiable net balance between podocyte loss and regeneration.  
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  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0085-2538 ISBN Medium  
  Area Expedition Conference  
  Notes Approved (up) no  
  Call Number UofT @ mathieu.lemaire @ Serial 45953  
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Author Astanina, K.; Koch, M.; Jüngst, C.; Zumbusch, A.; Kiemer, A.K. url  openurl
  Title Lipid droplets as a novel cargo of tunnelling nanotubes in endothelial cells Type Journal Article
  Year 2015 Publication Abbreviated Journal Sci Rep  
  Volume 5 Issue Pages 11453  
  Keywords  
  Abstract Intercellular communication is a fundamental process in the development and functioning of multicellular organisms. Recently, an essentially new type of intercellular communication, based on thin membrane channels between cells, has been reported. These structures, termed intercellular or tunnelling nanotubes (TNTs), permit the direct exchange of various components or signals (e.g., ions, proteins, or organelles) between non-adjacent cells at distances over 100 μm. Our studies revealed the presence of tunnelling nanotubes in microvascular endothelial cells (HMEC-1). The TNTs were studied with live cell imaging, environmental scanning electron microscopy (ESEM), and coherent anti-Stokes Raman scattering spectroscopy (CARS). Tunneling nanotubes showed marked persistence: the TNTs could connect cells over long distances (up to 150 μm) for several hours. Several cellular organelles were present in TNTs, such as lysosomes and mitochondria. Moreover, we could identify lipid droplets as a novel type of cargo in the TNTs. Under angiogenic conditions (VEGF treatment) the number of lipid droplets increased significantly. Arachidonic acid application not only increased the number of lipid droplets but also tripled the extent of TNT formation. Taken together, our results provide the first demonstration of lipid droplets as a cargo of TNTs and thereby open a new field in intercellular communication research.  
  Address  
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  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2045-2322 ISBN Medium  
  Area Expedition Conference  
  Notes Approved (up) no  
  Call Number UofT @ mathieu.lemaire @ Serial 45959  
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Author Allegretti, A.S.; Hundemer, G.; Chorghade, R.; Cosgrove, K.; Bajwa, E.; Bhan, I. openurl 
  Title Perspectives of continuous renal replacement therapy in the intensive care unit: a paired survey study of patient, physician, and nurse views Type Journal Article
  Year 2015 Publication Abbreviated Journal BMC Nephrol  
  Volume 16 Issue Pages 105  
  Keywords KRESCENT, jclub  
  Abstract BACKGROUND: Recent studies suggest discrepancies between patients and providers around perceptions of hemodialysis prognosis. Such data are lacking for continuous renal replacement therapy (CRRT). We aim to assess patient and provider understanding of outcomes around CRRT.
METHODS: From February 1 to August 31, 2013, a triad of (1) a patient on CRRT (or health care proxy [HCP]), (2) physician and (3) primary nurse from the intensive care unit (ICU) team were surveyed. Univariate chi-square and qualitative analysis techniques were used.
RESULTS: Ninety-six total participants (32 survey triads) were completed. Ninety one percent of patients/HCPs correctly identified that CRRT replaced the function of the kidneys. Six percent of patients/HCPs, 44 % of physicians, and 44 % of nurses identified rates of survival to hospital discharge that were consistent with published literature. Both physicians and nurses were more likely than patients/HCPs to assess survival consistently with published data (p = 0.001). Patients/HCPs were more likely to overestimate survival rates than physicians and nurses (p < 0.001). Thirty eight percent of patients/HCPs, 38 % of physicians, and 28 % of nurses identified rates of lifelong dialysis-dependence among surviving patients that were consistent with published literature.
CONCLUSIONS: There is mismatch between patients, HCPs, and providers around prognosis of CRRT. Patients/HCPs are more likely to overestimate chances of survival than physicians or nurses. Further intervention is needed to improve this knowledge gap.
 
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved (up) no  
  Call Number UofT @ mathieu.lemaire @ Serial 46000  
Permanent link to this record
 

 
Author Karabi Biswas url  doi
openurl 
  Title Biological Agents of Bioremediation: A Concise Review Type Journal Article
  Year 2015 Publication Frontiers in Environmental Microbiology Abbreviated Journal FEM  
  Volume 2 Issue 1 Pages 39-43  
  Keywords Bioremediation, Biological Organisms, Environmental Pollution  
  Abstract Due to intensive agriculture, rapid industrialization and anthropogenic activities have caused environmental pollution, land degradation and increased pressure on the natural resources and contributing to their adulteration. Bioremediation is the use of biological organisms to destroy, or reduce the hazardous wastes on a contaminated site. Bioremediation is the most potent management tool to control the environmental pollution and recover contaminated soil. Use of biological materials, coupled to other advanced processes is one of the most promising and inexpensive approaches for removing environmental pollutants. Bioremediation technology is a beneficial alternative which leads to degrade of pollutants. This article presents the important biological organisms used in bioremediation technologies.  
  Address  
  Corporate Author Thesis  
  Publisher http://www.sciencepublishinggroup.com Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2469-8067 ISBN Medium  
  Area Expedition Conference  
  Notes Approved (up) yes  
  Call Number Gbl @ satyendra.sharmma @ Serial 42617  
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Author Trivedi, Mahendra Kumar; Nayak, Gopal; Patil, Shrikant; Tallapragada, Rama Mohan; Latiyal, Omprakash url  doi
openurl 
  Title Studies of the Atomic and Crystalline Characteristics of Ceramic Oxide Nano Powders after Biofield Treatment Type Journal Article
  Year 2015 Publication Industrial Engineering & Management Abbreviated Journal  
  Volume 4 Issue 3 Pages  
  Keywords atomic characteristics of nano iron oxide; Iron oxide; Copper oxide; Zinc oxide; X-ray diffraction; FT-IR  
  Abstract Transition metal oxides (TMOs) have been known for their extraordinary electrical and magnetic properties. In the present study, some transition metal oxides (Zinc oxide, iron oxide and copper oxide) which are widely used in the fabrication of electronic devices were selected and subjected to biofield treatment. The atomic and crystal structures of TMOs were carefully studied by Fourier transform infrared (FT-IR) spectroscopy and X-ray diffraction (XRD) studies. XRD analysis reveals that biofield treatment significantly changed the lattice strain in unit cells, crystallite sizes and densities in ceramics oxide powders. The computed molecular weight of the treated samples exhibited significant variation. FT-IR spectra indicated that biofield treatment has altered the metal-oxygen bond strength. Since biofield treatment significantly altered the crystallite size, lattice strain and bond strength, we postulate that electrical and magnetic properties in TMOs (transition metal oxides) can be modulated by biofield treatment.  
  Address  
  Corporate Author Thesis  
  Publisher OMICS Publishing Group Place of Publication United States Editor  
  Language English Summary Language English Original Title Studies of the Atomic and Crystalline Characteristics of Ceramic Oxide Nano Powders after Biofield Treatment  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2169-0316 ISBN Medium  
  Area Materials Science Expedition Conference  
  Notes Approved (up) yes  
  Call Number Trivedi Global Inc. @ mahendra @ Serial 42618  
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Author Trivedi, Mahendra Kumar; Nayak, Gopal; Patil, Shrikant; Tallapragada, Rama Mohan; Latiyal, Omprakash url  doi
openurl 
  Title Impact of Biofield Treatment on Physical, Structural and Spectral Properties of Antimony Sulfide Type Journal Article
  Year 2015 Publication Industrial Engineering & Management Abbreviated Journal  
  Volume 4 Issue 3 Pages  
  Keywords Biofield treatment; Antimony sulfide; X-ray diffraction; FT-IR; Particle size; Surface area; Scanning electron microscopy  
  Abstract Antimony sulfide (Sb2S3) has gained extensive attention in solar cells due to their potential as a low-cost and earth abundant absorber material. In solar cell absorber, the optoelectrical properties such as energy band gap and absorption coefficient of Sb2S3play an important role, which have strong relationships with their crystal structure, lattice parameter and crystallite size.

Hence in the present investigation, Sb2S3 powder samples were exposed to biofield treatment, and further its physical, structural and spectral properties are investigated. The particle size analysis showed larger particle size and surface area after treatment. X-ray diffraction (XRD) analysis revealed polycrystalline orthorhombic structure with superior crystallinity in treated Sb2S3along with significant changes in the lattice parameters, which led to changes in unit cell volume and density. XRD data analysis indicates that crystallite size was increased by around 150% in treated sample. In FT-IR spectra, strong absorption band was observed at 400-700cm-1, which confirms the presence of Sb2S3. Further, the absorption peak intensity in IR spectra was significantly reduced after treatment that was probably due to change in metal sulphur dipolar interaction.
 
  Address  
  Corporate Author Thesis  
  Publisher OMICS Publishing Group Place of Publication United States Editor  
  Language English Summary Language English Original Title Impact of Biofield Treatment on Physical, Structural and Spectral Properties of Antimony Sulfide  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2169-0316 ISBN Medium  
  Area Materials Science Expedition Conference  
  Notes Approved (up) yes  
  Call Number Trivedi Global Inc. @ mahendra @ Serial 42621  
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