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Author (up) Butterfield, L.H. url  openurl
  Title Cancer vaccines Type Journal Article
  Year 2015 Publication Abbreviated Journal Bmj  
  Volume 350 Issue Pages h988  
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  Abstract Cancer vaccines are designed to promote tumor specific immune responses, particularly cytotoxic CD8 positive T cells that are specific to tumor antigens. The earliest vaccines, which were developed in 1994-95, tested non-mutated, shared tumor associated antigens that had been shown to be immunogenic and capable of inducing clinical responses in a minority of people with late stage cancer. Technological developments in the past few years have enabled the investigation of vaccines that target mutated antigens that are patient specific. Several platforms for cancer vaccination are being tested, including peptides, proteins, antigen presenting cells, tumor cells, and viral vectors. Standard of care treatments, such as surgery and ablation, chemotherapy, and radiotherapy, can also induce antitumor immunity, thereby having cancer vaccine effects. The monitoring of patients’ immune responses at baseline and after standard of care treatment is shedding light on immune biomarkers. Combination therapies are being tested in clinical trials and are likely to be the best approach to improving patient outcomes.  
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  Call Number UofT @ ankit.sinha @ Serial 45100  
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Author (up) Byrne, O.; Shepherd, D.A. doi  openurl
  Title Different Strokes for Different Folks: Entrepreneurial Narratives of Emotion, Cognition, and Making Sense of Business Failure Type Journal Article
  Year 2015 Publication Entrepreneurship Theory and Practice Abbreviated Journal Entrepreneurship Theory and Practice  
  Volume 39 Issue 2 Pages 375-405  
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  Abstract This multiple case study of eight entrepreneurial narratives of failed businesses examines how narratives that express different emotional states (folks) reflect different efforts to make sense of failure experiences (strokes). Our comparisons of the narratives' emotional content (describing emotional states at the time of business failure and presently) revealed some new insights. First, high negative emotions motivate making sense of a loss, while high positive emotions provide cognitive resources to facilitate and motivate making sense of the failure event. Second, emotion-focused coping helped deal with negative emotions. Finally, sensemaking was also facilitated by cognitive strategies that focused attention on the failure event and promoted self-reflection.  
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  ISSN 1540-6520 ISBN Medium  
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  Notes Approved no  
  Call Number ATM @ robstephens13 @ Serial 41273  
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Author (up) Cajigas, I.; Leib, D.E.; Cochrane, J.; Luo, H.; Swyter, K.R.; Chen, S.; Clark, B.S.; Thompson, J.; Yates, J.R.; Kingston, R.E.; Kohtz, J.D. openurl 
  Title Evf2 lncRNA/BRG1/DLX1 interactions reveal RNA-dependent inhibition of chromatin remodeling Type Journal Article
  Year 2015 Publication Abbreviated Journal Development (Cambridge, England)  
  Volume 142 Issue 15 Pages 2641--2652  
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  Abstract Transcription-regulating long non-coding RNAs (lncRNAs) have the potential to control the site-specific expression of thousands of target genes. Previously, we showed that Evf2, the first described ultraconserved lncRNA, increases the association of transcriptional activators (DLX homeodomain proteins) with key DNA enhancers but represses gene expression. In this report, mass spectrometry shows that the Evf2-DLX1 ribonucleoprotein (RNP) contains the SWI/SNF-related chromatin remodelers Brahma-related gene 1 (BRG1, SMARCA4) and Brahma-associated factor (BAF170, SMARCC2) in the developing mouse forebrain. Evf2 RNA colocalizes with BRG1 in nuclear clouds and increases BRG1 association with key DNA regulatory enhancers in the developing forebrain. While BRG1 directly interacts with DLX1 and Evf2 through distinct binding sites, Evf2 directly inhibits BRG1 ATPase and chromatin remodeling activities. In vitro studies show that both RNA-BRG1 binding and RNA inhibition of BRG1 ATPase/remodeling activity are promiscuous, suggesting that context is a crucial factor in RNA-dependent chromatin remodeling inhibition. Together, these experiments support a model in which RNAs convert an active enhancer to a repressed enhancer by directly inhibiting chromatin remodeling activity, and address the apparent paradox of RNA-mediated stabilization of transcriptional activators at enhancers with a repressive outcome. The importance of BRG1/RNA and BRG1/homeodomain interactions in neurodevelopmental disorders is underscored by the finding that mutations in Coffin-Siris syndrome, a human intellectual disability disorder, localize to the BRG1 RNA-binding and DLX1-binding domains.  
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  ISSN 1477-9129 ISBN Medium  
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  Notes Approved no  
  Call Number AG @ matthewjvarga @ Serial 47024  
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Author (up) Calignano, F.; Tommasi, T.; Manfredi, D.; Chiolerio, A. url  openurl
  Title Additive Manufacturing of a Microbial Fuel Cell – A detailed study Type Journal Article
  Year 2015 Publication Abbreviated Journal Scientific Reports  
  Volume 5 Issue Pages  
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  Notes Cited By :1; Export Date: 2 November 2016 Approved no  
  Call Number IIT-CSF @ alessandro.chiolerio @ Serial 42774  
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Author (up) Chakravarty, S.; Shahriar, A.Z.M. doi  openurl
  Title Selection of Borrowing Partners in Joint Liability-Based Microcredit: Evidence from Framed Field Experiments in Bangladesh Type Journal Article
  Year 2015 Publication Entrepreneurship Theory and Practice Abbreviated Journal Entrepreneurship Theory and Practice  
  Volume 39 Issue 1 Pages 129-144  
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  Abstract We analyze partner selection decisions in the formation of borrowing groups in joint liability-based microcredit. We do so within the context of a framed field experiment with the owners of small businesses in rural Bangladesh. We find that when, irrespective of their project status, borrowers are required to make joint liability payments, risky borrowers will offer side payments that are sufficiently large to attract safe borrowers, leading to the formation of heterogeneous risk-matched groups. We discuss the implications of heterogeneous risk matching for the survival and success of small enterprises, and their financiers, in countries with a weak institutional environment.  
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  ISSN 1540-6520 ISBN Medium  
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  Notes Approved no  
  Call Number ATM @ robstephens13 @ Serial 41742  
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Author (up) Chalavi, S.; Vissia, E.M.; Giesen, M.E.; Nijenhuis, E.R.S.; Draijer, N.; Barker, G.J.; Veltman, D.J.; Reinders, A.A.T.S. url  doi
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  Title Similar cortical but not subcortical gray matter abnormalities in women with posttraumatic stress disorder with versus without dissociative identity disorder Type Journal Article
  Year 2015 Publication Psychiatry Research Abbreviated Journal Psychiatry Res  
  Volume 231 Issue 3 Pages 308-319  
  Keywords Adolescent; Adult; Cerebral Cortex/*pathology; Comorbidity; Corpus Striatum/*pathology; Female; Gray Matter/*pathology; Hippocampus/pathology; Humans; *Life Change Events; Magnetic Resonance Imaging; Middle Aged; Multiple Personality Disorder/epidemiology/*pathology; Stress Disorders, Post-Traumatic/epidemiology/*pathology; Young Adult; Cortical surface area; Cortical thickness; Cortical volume; FreeSurfer; Neuroimaging; Subcortical volume  
  Abstract Neuroanatomical evidence on the relationship between posttraumatic stress disorder (PTSD) and dissociative disorders is still lacking. We acquired brain structural magnetic resonance imaging (MRI) scans from 17 patients with dissociative identity disorder (DID) and co-morbid PTSD (DID-PTSD) and 16 patients with PTSD but without DID (PTSD-only), and 32 healthy controls (HC), and compared their whole-brain cortical and subcortical gray matter (GM) morphological measurements. Associations between GM measurements and severity of dissociative and depersonalization/derealization symptoms or lifetime traumatizing events were evaluated in the patient groups. DID-PTSD and PTSD-only patients, compared with HC, had similarly smaller cortical GM volumes of the whole brain and of frontal, temporal and insular cortices. DID-PTSD patients additionally showed smaller hippocampal and larger pallidum volumes relative to HC, and larger putamen and pallidum volumes relative to PTSD-only. Severity of lifetime traumatizing events and volume of the hippocampus were negatively correlated. Severity of dissociative and depersonalization/derealization symptoms correlated positively with volume of the putamen and pallidum, and negatively with volume of the inferior parietal cortex. Shared abnormal brain structures in DID-PTSD and PTSD-only, small hippocampal volume in DID-PTSD, more severe lifetime traumatizing events in DID-PTSD compared with PTSD-only, and negative correlations between lifetime traumatizing events and hippocampal volume suggest a trauma-related etiology for DID. Our results provide neurobiological evidence for the side-by-side nosological classification of PTSD and DID in the DSM-5.  
  Address Department of Neuroscience, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Department of Psychosis Studies, Institute of Psychiatry (IoP), Kings College London, De Crespigny Park, P.O. Box 40, London SE5 8AF, United Kingdom. Electronic address: a.a.t.s.reinders@gmail.com  
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  ISSN 0165-1781 ISBN Medium  
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  Notes PMID:25670646 Approved no  
  Call Number UU @ jana.mullerova @ Serial 42194  
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Author (up) Chanam, J.; Kasinathan, S.; Pramanik, G.K.; Jagdeesh, A.; Joshi, K.A.; Borges, R.M. openurl 
  Title Foliar extrafloral nectar of Humboldtia brunonis (Fabaceae), a paleotropic ant–plant, is richer than phloem sap and more attractive than honeydew Type Journal Article
  Year 2015 Publication Abbreviated Journal Biotropica  
  Volume 47 Issue 1 Pages 1-5  
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  ISSN 1744-7429 ISBN Medium  
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  Notes Approved no  
  Call Number CES @ dilipnaidu.gt @ Serial 42992  
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Author (up) Chiolerio, A.; Bocchini, S.; Scaravaggi, F.; Porro, S.; Perrone, D.; Beretta, D.; Caironi, M.; Fabrizio Pirri, C. url  openurl
  Title Synthesis of polyaniline-based inks for inkjet printed devices: Electrical characterization highlighting the effect of primary and secondary doping Type Journal Article
  Year 2015 Publication Abbreviated Journal Semiconductor Science and Technology  
  Volume 30 Issue 10 Pages  
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  Notes Cited By :4; Export Date: 2 November 2016 Approved no  
  Call Number IIT-CSF @ alessandro.chiolerio @ Serial 42777  
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Author (up) Chiolerio, A.; Camarchia, V.; Quaglia, R.; Pirola, M.; Pandolfi, P.; Pirri, C.F. url  openurl
  Title Hybrid Ag-based inks for nanocomposite inkjet printed lines: RF properties Type Journal Article
  Year 2015 Publication Abbreviated Journal Journal of Alloys and Compounds  
  Volume 615 Issue S1 Pages S501-S504  
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  Notes Cited By :6; Export Date: 2 November 2016 Approved no  
  Call Number IIT-CSF @ alessandro.chiolerio @ Serial 42779  
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Author (up) Chiolerio, A.; Roppolo, I.; Cauda, V.; Crepaldi, M.; Bocchini, S.; Bejtka, K.; Verna, A.; Pirri, C.F. url  openurl
  Title Ultraviolet mem-sensors: flexible anisotropic composites featuring giant photocurrent enhancement Type Journal Article
  Year 2015 Publication Abbreviated Journal Nano Research  
  Volume 8 Issue 6 Pages 1956-1963  
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  Notes Cited By :6; Export Date: 2 November 2016 Approved no  
  Call Number IIT-CSF @ alessandro.chiolerio @ Serial 42778  
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