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Author (up) Aoki-Kinoshita, K.F. isbn  openurl
  Title Glycoinformatics: Overview Type Book Chapter
  Year 2015 Publication Glycoinformatics: Overview Abbreviated Journal  
  Volume Glycoscience: Biology and Medicine Issue Pages 185-192  
  Keywords  
  Abstract Because of the many different glycan-related databases now publicly available, a number of different glycan structure representations are used to graphically and textually display glycans structures. This overview provides an easy reference to each representation format as well as links to several major databases and web resources that may be useful for glycobiologists. Many of the major databases, glycan sequence and structure representation formats, and tools that are currently available and used in the glycoscience field will be …  
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  Publisher Springer Place of Publication Tokyo Editor Endo, T.; Seeberger, P.H.; Hart, G.W.; Wong, C.-H.; Taniguchi, N.  
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  Series Volume Series Issue Edition  
  ISSN ISBN 978-4-431-54836-2 Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number UofT @ mathieu.lemaire @ Serial 45629  
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Author (up) Ariceta, G.; Lara, E.; Camacho, J.A.; Oppenheimer, F.; Vara, J.; Santos, F.; Muñoz, M.A.; Cantarell, C.; Gil Calvo, M.; Romero, R.; Valenciano, B.; García-Nieto, V.; Sanahuja, M.J.; Crespo, J.; Justa, M.L.; Urisarri, A.; Bedoya, R.; Bueno, A.; Daza, A.; Bravo, J.; Llamas, F.; Jiménez Del Cerro, L.A. url  openurl
  Title Cysteamine (Cystagon®) adherence in patients with cystinosis in Spain: successful in children and a challenge in adolescents and adults Type Journal Article
  Year 2015 Publication Abbreviated Journal Nephrol Dial Transplant  
  Volume 30 Issue 3 Pages 475-480  
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  Abstract BACKGROUND: Cysteamine has improved survival and prognosis in cystinosis. Increasing numbers of patients reach adulthood and face new challenges such as compliance that wanes over time. The aim of this study was to evaluate adherence to cysteamine treatment in a group of cystinotic patients in Spain in an attempt to identify potential therapy pitfalls and improve the overall care of affected individuals. Despite the impact of cysteamine on prognosis, there is a paucity of data regarding adherence. METHOD: Thirty-four cystinotic patients (21 male) 38% ≥18 years were enrolled in a voluntary, anonymous survey. Replies were obtained from patients (15/34), mothers (11/34), fathers (4/34) and both parents (4/34). RESULTS: Patient age (median and interquartile range) at diagnosis was 1 year (0.57-1), and patient age at Cystagon® initiation was also 1 year (0.8-1.8). Sixteen (47%) were kidney transplant (KTx) recipients; six were retransplanted. Age at first KTx 10 years (8.7-13.7). Patient understanding of multiorgan involvement in cystinosis: 4.1 organs reported; eye 97% and kidney 91%. Cysteamine was given by mother (100%) and father (83%) in <11 year olds, or self-administered (94%) in ≥11 year olds. Four daily doses in 89% versus 56% in <11 year olds or ≥11 year olds, with fixed schedule in 94% versus 50% in <11 or ≥11 year olds and progressive loss of reminders over time. Furthermore, 44% complained of unpleasant smell. Motivation for treatment compliance was 100% versus 40% in <11 versus ≥11 year olds, respectively. Disease impact in patients <18 years is as follows: school (29%), social (14%), ‘feeling different’ (10%); in patients ≥18 years: ‘feeling different’ (62%), professional (39%) and job absenteeism (31%). Referring physician: paediatric nephrologist (94%) and nephrologist (63%) in <11 versus ≥11 year olds. Ophthalmological follow-up: 83% versus 38% in <11 versus ≥11 year olds. Patient opinion of physician expertise: paediatric nephrologist (94%) and nephrologist (44%). New treatment options (65%) and better information (42%) were demanded to improve adherence. CONCLUSION: Treatment with Cystagon is effective in young patients. However, adherence diminishes over time in adolescents and adults despite disease impact. Strategies such as better information on the disease, patient self-care promotion and facilitated transition to adult healthcare services are required to improve compliance and the clinical management of cystinosis.  
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  ISSN 0931-0509 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number UofT @ mathieu.lemaire @ Serial 45856  
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Author (up) Armour, C.; Hansen, M. url  doi
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  Title Assessing DSM-5 latent subtypes of acute stress disorder dissociative or intrusive? Type Journal Article
  Year 2015 Publication Psychiatry Research Abbreviated Journal Psychiatry Res  
  Volume 225 Issue 3 Pages 476-483  
  Keywords Adult; Age Factors; *Diagnostic and Statistical Manual of Mental Disorders; Dissociative Disorders/classification/*diagnosis/psychology; Female; Humans; Male; Middle Aged; Risk Factors; Social Support; Stress Disorders, Traumatic, Acute/classification/*diagnosis/psychology; ASD subtypes; Dissociative ASD; Intrusive ASD; Latent profile analysis; Risk factors  
  Abstract Acute Stress Disorder (ASD) was first included in the DSM-IV in 1994. It was proposed to account for traumatic responding in the early post trauma phase and to act as an identifier for later Posttraumatic Stress Disorder (PTSD). Unlike PTSD it included a number of dissociative indicators. The revised DSM-5 PTSD criterion included a dissociative-PTSD subtype. The current study assessed if a dissociative-ASD subtype may be present for DSM-5 ASD. Moreover, we assessed if a number of risk factors resulted in an increased probability of membership in symptomatic compared to a baseline ASD profile. We used data from 450 bank robbery victims. Latent profile analysis (LPA) was used to uncover latent profiles of ASD. Multinomial logistic regression was used to determine if female gender, age, social support, peritraumatic panic, somatization, and number of trauma exposures increased or decreased the probability of profile membership. Four latent profiles were uncovered and included an intrusion rather than dissociative subtype. Increased age and social support decreased the probability of individuals being grouped into the intrusion subtype whereas increased peritraumatic panic and somatization increased the probability of individuals being grouped into the intrusion subtype. Findings are discussed in regard to the ICD-11 and the DSM-5.  
  Address National Centre for Psychotraumatology, Institute for Psychology, University of Southern Denmark, Denmark  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 0165-1781 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25535010 Approved no  
  Call Number UU @ jana.mullerova @ Serial 42196  
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Author (up) Arregle, J.-L.; Batjargal, B.; Hitt, M.A.; Webb, J.W.; Miller, T.; Tsui, A.S. doi  openurl
  Title Family Ties in Entrepreneurs' Social Networks and New Venture Growth Type Journal Article
  Year 2015 Publication Entrepreneurship Theory and Practice Abbreviated Journal Entrepreneurship Theory and Practice  
  Volume 39 Issue 2 Pages 313-344  
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  Abstract Family ties are an important conduit of resources for entrepreneurs, but both positive and negative outcomes can arise. Building upon a family embeddedness perspective, we develop hypotheses about curvilinear relationships between the proportion of family ties in entrepreneurs' networks and venture growth. We test them on entrepreneurs from China, France, Russia, and the United States. These effects appear to be related to the type of entrepreneurs' social network (business advice, emotional support, and business resources). Our results confirm effects specific to each network: an inverted U-shape for advice and emotional support networks but a U-shape for the business resource network, measuring what proportion of kin in each entrepreneurial network type is valuable to or, conversely, undermines new venture growth.  
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  ISSN 1540-6520 ISBN Medium  
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  Notes Approved no  
  Call Number ATM @ robstephens13 @ Serial 41609  
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Author (up) Ashalakshmi, N.C.; Nag, K.S.C.; Karanth, K.P. doi  openurl
  Title Molecules support morphology: species status of South Indian populations of the widely distributed Hanuman langur Type Journal Article
  Year 2015 Publication Abbreviated Journal Conservation Genetics  
  Volume 16 Issue 1 Pages 43-58  
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  Abstract The taxonomy of the Hanuman langur (Semnopithecus spp.), a widely distributed Asian colobine monkey, has been in a flux for a long time due to much disagreement between various classification schemes. However, results from a recent field-based morphological study were consistent with Hill’s (Ceylon J Sci 21:277–305, 1939) species level classification scheme. Here we tested the validity of S. hypoleucos and S. priam, the two South Indian species recognized by Hill. To this end, one mitochondrial and four nuclear markers were sequenced from over 72 non-invasive samples of Hanuman langurs and S. johnii collected from across India. The molecular data were subjected to various tree building methods. The nuclear data was also used in a Bayesian structure analysis and to determine the genealogical sorting index of each hypothesized species. Results from nuclear data suggest that the South Indian population of Hanuman langur consists of two units that correspond to the species recognized by Hill. However in the mitochondrial tree S. johnii and S. priam were polyphyletic probably due to retention of ancestral polymorphism and/or low levels of hybridization. Implications of these results on conservation of Hanuman langurs are also discussed.  
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  ISSN 1572-9737 ISBN Medium  
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  Notes Approved no  
  Call Number CES @ dilipnaidu.gt @ Serial 42966  
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Author (up) Astanina, K.; Koch, M.; Jüngst, C.; Zumbusch, A.; Kiemer, A.K. url  openurl
  Title Lipid droplets as a novel cargo of tunnelling nanotubes in endothelial cells Type Journal Article
  Year 2015 Publication Abbreviated Journal Sci Rep  
  Volume 5 Issue Pages 11453  
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  Abstract Intercellular communication is a fundamental process in the development and functioning of multicellular organisms. Recently, an essentially new type of intercellular communication, based on thin membrane channels between cells, has been reported. These structures, termed intercellular or tunnelling nanotubes (TNTs), permit the direct exchange of various components or signals (e.g., ions, proteins, or organelles) between non-adjacent cells at distances over 100 μm. Our studies revealed the presence of tunnelling nanotubes in microvascular endothelial cells (HMEC-1). The TNTs were studied with live cell imaging, environmental scanning electron microscopy (ESEM), and coherent anti-Stokes Raman scattering spectroscopy (CARS). Tunneling nanotubes showed marked persistence: the TNTs could connect cells over long distances (up to 150 μm) for several hours. Several cellular organelles were present in TNTs, such as lysosomes and mitochondria. Moreover, we could identify lipid droplets as a novel type of cargo in the TNTs. Under angiogenic conditions (VEGF treatment) the number of lipid droplets increased significantly. Arachidonic acid application not only increased the number of lipid droplets but also tripled the extent of TNT formation. Taken together, our results provide the first demonstration of lipid droplets as a cargo of TNTs and thereby open a new field in intercellular communication research.  
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  ISSN 2045-2322 ISBN Medium  
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  Notes Approved no  
  Call Number UofT @ mathieu.lemaire @ Serial 45959  
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Author (up) Astudillo, L.; Sabourdy, F.; Therville, N.; Bode, H.; Ségui, B.; Andrieu-Abadie, N.; Hornemann, T.; Levade, T. url  openurl
  Title Human genetic disorders of sphingolipid biosynthesis Type Journal Article
  Year 2015 Publication Abbreviated Journal J Inherit Metab Dis  
  Volume 38 Issue 1 Pages 65-76  
  Keywords research support, non-u.s. gov’t; lipid human disease  
  Abstract Monogenic defects of sphingolipid biosynthesis have been recently identified in human patients. These enzyme deficiencies affect the synthesis of sphingolipid precursors, ceramides or complex glycosphingolipids. They are transmitted as autosomal recessive or dominant traits, and their resulting phenotypes often replicate the abnormalities seen in murine models deficient for the corresponding enzymes. In quite good agreement with the known critical roles of sphingolipids in cells from the nervous system and the epidermis, these genetic defects clinically manifest as neurological disorders, including paraplegia, epilepsy or peripheral neuropathies, or present with ichthyosis. The present review summarizes the genetic alterations, biochemical changes and clinical symptoms of this new group of inherited metabolic disorders. Hypotheses regarding the molecular pathophysiology and potential treatments of these diseases are also discussed.  
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  ISSN 0141-8955 ISBN Medium  
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  Notes Approved no  
  Call Number UofT @ mathieu.lemaire @ Serial 45621  
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Author (up) Świderek, K.; Tuñón, I.; Martí, S.; Moliner, V. url  openurl
  Title Protein Conformational Landscapes and Catalysis. Influence of Active Site Conformations in the Reaction Catalyzed by L-Lactate Dehydrogenase Type Journal Article
  Year 2015 Publication Abbreviated Journal ACS Catal  
  Volume 5 Issue 4 Pages 1172-1185  
  Keywords KIEs LDH QM/MM free energy surfaces reaction mechanism single-molecule experiments  
  Abstract In the last decade L-Lactate Dehydrogenase (LDH) has become an extremely useful marker in both clinical diagnosis and in monitoring the course of many human diseases. It has been assumed from the 80s that the full catalytic process of LDH starts with the binding of the cofactor and the substrate followed by the enclosure of the active site by a mobile loop of the protein before the reaction to take place. In this paper we show that the chemical step of the LDH catalyzed reaction can proceed within the open loop conformation, and the different reactivity of the different protein conformations would be in agreement with the broad range of rate constants measured in single molecule spectrometry studies. Starting from a recently solved X-ray diffraction structure that presented an open loop conformation in two of the four chains of the tetramer, QM/MM free energy surfaces have been obtained at different levels of theory. Depending on the level of theory used to describe the electronic structure, the free energy barrier for the transformation of pyruvate into lactate with the open conformation of the protein varies between 12.9 and 16.3 kcal/mol, after quantizing the vibrations and adding the contributions of recrossing and tunneling effects. These values are very close to the experimentally deduced one (14.2 kcal·mol^-1^) and ~2 kcal·mol^-1^ smaller than the ones obtained with the closed loop conformer. Calculation of primary KIEs and IR spectra in both protein conformations are also consistent with our hypothesis and in agreement with experimental data. Our calculations suggest that the closure of the active site is mainly required for the inverse process; the oxidation of lactate to pyruvate. According to this hypothesis H4 type LDH enzyme molecules, where it has been propose that lactate is transformed into pyruvate, should have a better ability to close the mobile loop than the M4 type LDH molecules.  
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  ISSN 2155-5435 ISBN Medium  
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  Notes Null Approved no  
  Call Number AG @ matthewjvarga @ Serial 46623  
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Author (up) Auxemery, Y. url  doi
openurl 
  Title [Clinical forms of post-traumatic depression] Type Journal Article
  Year 2015 Publication L'Encephale Abbreviated Journal Encephale  
  Volume 41 Issue 4 Pages 346-354  
  Keywords Deuil post-traumatique; Deuil traumatique; Depression masquee; Depression post-traumatique; Depression traumatique; Post-concussive syndrome; Posttraumatic depression; Posttraumatic grief; Psychic trauma; Psychopathologie; Psychopathology; Psychopharmacologie; Psychopharmacology; Syndrome post-commotionnel; Traumatic depression; Traumatic grief; Traumatisme psychique  
  Abstract INTRODUCTION: As a result of determinants specific to the psychopathological structure of the psychological trauma, psycho-traumatised patients very rarely solicit the health care system directly with a request for treatment centred on their trauma. The medical profession is consulted for non-specific symptoms and complications, which are mainly somatoform, addictions and depressive disorders. After a few epidemiological reminders followed by a discussion concerning contemporary depressive and post-traumatic nosographic features, we define, through our clinical experience collated with the data in the literature, different clinical and etiopathogenic contexts of post-traumatic depression in order to control their therapeutic treatment. CLINICAL FINDINGS: Burnout post-traumatic depression in response to re-experiencing is the most common: it is a reactive psycho-physiological burnout in response to the emotional distress re-experienced during flashbacks, insomnia, a constant feeling of insecurity and the deleterious consequences of this symptomatology in terms of social adaptation. A common genetic predisposition affecting serotoninergic regulation seems to be a vulnerability marker of both depressive and psychotraumatic symptoms. In this case, SSRI will be effective on sadness. In addition, these antidepressants have been widely prescribed for the first-line treatment of depressive and psychotraumatic symptoms. However, this pharmacological class is often insufficient in relieving autonomic hyperactivity such as re-experiencing which are mediated more by noradrenergic hyperactivity. SNRI such as venlafaxine can be used as a first-line treatment. Post-traumatic depression with psychotic features congruent with mood is dominated by a feeling of incurability; the subject blames himself and feels guilty about the traumatic event and its consequences. Symptoms of denial of identity are sometimes observed: confined by an intense depersonalization, the psycho-traumatised subject evokes that he is “no longer himself” and that his mind “is disconnected”. Confronted with the psychological emptiness of the traumatic scene, the psycho-traumatised subject remains devoid of thought as if their mind has left him. In addition to antidepressant therapy, an atypical antipsychotic drug must be prescribed to relieve the melancholic symptoms as well as the concomitant psychotraumatic symptoms. Post-traumatic depression masked by peripheral physical injuries is the result of accidents combining psychological and physical impairment. The physical pain resulting from the accident regularly recalls the drama in the same way as traumatic re-experiencing. Depression masked by this somatic suffering is difficult to diagnose, but the repeated somatic complaints at the forefront of the request for treatment, the breakdown of self-esteem as well as the level of subjective strain due to pain and dysesthesia are all indications. The psychotherapy will focus on the symbolic reconstruction of the organs that have been damaged or destroyed, with the aim of healing the extensive narcissistic impairment. Post-concussive depression is diagnosed following a head trauma, however severe. It is sometimes assigned to neurological lesions and at other times recognised as the expression of a purely psychological reaction. Antidepressant therapy, or possibly trial therapy, is often indicated. The terms traumatic grief and post-traumatic grief are often used synonymously in publications: a conceptual opposition must however been recalled. If the traumatic grief is the result of the loss of an object that holds much psychological importance for the individual, the subject has not however been traumatised by this event and is not suffering and will not suffer from re-experiencing. The therapy will include methods used in the psychotherapeutic treatment of grief; antidepressants are often insufficient. Differently, post-traumatic grief takes shape when the loss of another is concomitant with the confrontation with the reality of the death witnessed in a moment of peri-traumatic dissociation. This grief is often observed following the discovery of the body of a close friend or family member who has committed suicide, or when part of a family has been decimated by an accident whilst the survivors watch their close relations die pending the arrival of the emergency services, or when a military comrade is wounded in combat in front of his partner. The mourning process cannot really begin until the flashbacks cease. CONCLUSIONS: Clinical depression or even melancholia, possibly masked by somatic or post-concussive complaints, is often the initial mode of contact with the health care system for the psycho-traumatised subject. The different clinical and etiopathogenic contexts of post-traumatic depression that we have developed in this work use specific therapies which need to be clarified by further research based on this nosography.  
  Address Service medical de psychologie clinique appliquee a l'aeronautique, hopital d'instruction des Armees Percy, 101, avenue Henri-Barbusse, BP406, 92141 Clamart, France. Electronic address: yann.auxemery@hotmail.fr  
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  Language French Summary Language Original Title Formes cliniques des depressions post-traumatiques  
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  ISSN 0013-7006 ISBN Medium  
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  Notes PMID:25238908 Approved no  
  Call Number UU @ jana.mullerova @ Serial 42198  
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Author (up) Øverbye, A.; Skotland, T.; Koehler, C.J.; Thiede, B.; Seierstad, T.; Berge, V.; Sandvig, K.; Llorente, A. url  openurl
  Title Identification of prostate cancer biomarkers in urinary exosomes Type Journal Article
  Year 2015 Publication Abbreviated Journal Oncotarget  
  Volume 6 Issue 30 Pages 30357-30376  
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  Abstract Exosomes have recently appeared as a novel source of non-invasive cancer biomarkers since tumour-specific molecules can be found in exosomes isolated from biological fluids. We have here investigated the proteome of urinary exosomes by using mass spectrometry to identify proteins differentially expressed in prostate cancer patients compared to healthy male controls. In total, 15 control and 16 prostate cancer samples of urinary exosomes were analyzed. Importantly, 246 proteins were differentially expressed in the two groups. The majority of these proteins (221) were up-regulated in exosomes from prostate cancer patients. These proteins were analyzed according to specific criteria to create a focus list that contained 37 proteins. At 100% specificity, 17 of these proteins displayed individual sensitivities above 60%. Even though several of these proteins showed high sensitivity and specificity for prostate cancer as individual biomarkers, combining them in a multi-panel test has the potential for full differentiation of prostate cancer from non-disease controls. The highest sensitivity, 94%, was observed for transmembrane protein 256 (TM256; chromosome 17 open reading frame 61). LAMTOR proteins were also distinctly enriched with very high specificity for patient samples. TM256 and LAMTOR1 could be used to augment the sensitivity to 100%. Other prominent proteins were V-type proton ATPase 16 kDa proteolipid subunit (VATL), adipogenesis regulatory factor (ADIRF), and several Rab-class members and proteasomal proteins. In conclusion, this study clearly shows the potential of using urinary exosomes in the diagnosis and clinical management of prostate cancer.  
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  Notes Approved no  
  Call Number UofT @ ankit.sinha @ Serial 45334  
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