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Author (up) Ferlay, J.; Soerjomataram, I.; Dikshit, R.; Eser, S.; Mathers, C.; Rebelo, M.; Parkin, D.M.; Forman, D.; Bray, F. url  openurl
  Title Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012 Type Journal Article
  Year 2015 Publication Abbreviated Journal Int J Cancer  
  Volume 136 Issue 5 Pages E359-86  
  Keywords  
  Abstract Estimates of the worldwide incidence and mortality from 27 major cancers and for all cancers combined for 2012 are now available in the GLOBOCAN series of the International Agency for Research on Cancer. We review the sources and methods used in compiling the national cancer incidence and mortality estimates, and briefly describe the key results by cancer site and in 20 large “areas” of the world. Overall, there were 14.1 million new cases and 8.2 million deaths in 2012. The most commonly diagnosed cancers were lung (1.82 million), breast (1.67 million), and colorectal (1.36 million); the most common causes of cancer death were lung cancer (1.6 million deaths), liver cancer (745,000 deaths), and stomach cancer (723,000 deaths).  
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  Notes Approved no  
  Call Number UofT @ ankit.sinha @ Serial 45319  
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Author (up) Foo, M.-D.; Uy, M.A.; Murnieks, C. doi  openurl
  Title Beyond Affective Valence: Untangling Valence and Activation Influences on Opportunity Identification Type Journal Article
  Year 2015 Publication Entrepreneurship Theory and Practice Abbreviated Journal Entrepreneurship Theory and Practice  
  Volume 39 Issue 2 Pages 407-431  
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  Abstract Research surrounding how entrepreneurs identify opportunities focuses on the impact of affective valence on entrepreneurs' cognitive processes. Extending this body of research, we theorize how affective valence and affective activation work together to impact opportunity identification. We emphasize that to understand affective influences, both valence and activation should be included because they each influence active search effort and knowledge integration. We discuss the theoretical and practical implications of our study and suggest that future research should include more dynamic relationships among affect and entrepreneurial outcomes.  
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  Series Volume Series Issue Edition  
  ISSN 1540-6520 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number ATM @ robstephens13 @ Serial 41444  
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Author (up) Ford, J.D.; Mendelsohn, M.; Opler, L.A.; Opler, M.G.A.; Kallivayalil, D.; Levitan, J.; Pratts, M.; Muenzenmaier, K.; Shelley, A.-M.; Grennan, M.S.; Lewis Herman, J. url  doi
openurl 
  Title The Symptoms of Trauma Scale (SOTS): An Initial Psychometric Study Type Journal Article
  Year 2015 Publication Journal of Psychiatric Practice Abbreviated Journal J Psychiatr Pract  
  Volume 21 Issue 6 Pages 474-483  
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  Abstract The Symptoms of Trauma Scale (SOTS) is a 12-item, interview-based, clinician-rated measure that assesses the severity of a range of trauma-related symptoms. This pilot study evaluated its use and psychometric properties in an outpatient setting that provides treatment to survivors of chronic interpersonal trauma. Thirty participants completed self-report measures of posttraumatic stress symptoms, depression, dissociation, self-esteem, and affect dysregulation; the participants also participated separately in a semistructured interview based on the SOTS conducted by 2 trained interviewers. SOTS composite severity scores for DSM-IV posttraumatic stress disorder (PTSD) and complex PTSD (cPTSD), DSM-5 PTSD, and PTSD dissociative subtype, and total traumatic stress symptoms generally had acceptable internal consistency and interrater reliability. Evidence of convergent, discriminant, criterion, and construct validity was found for the SOTS composite PTSD scores, although potential limitations to validity that require further research and refinement of the measure were identified for the SOTS total and DSM-IV cPTSD scores and the hyperarousal, affect dysregulation, and dissociation items. Interviewers and interviewees described the interview as efficient, informative, and well tolerated. Implications for clinical practice and research to refine the SOTS are discussed.  
  Address FORD: Department of Psychiatry, University of Connecticut Health Center, Farmington, CT MENDELSOHN, KALLIVAYALIL, and HERMAN: Department of Psychiatry, Cambridge Health Alliance/Harvard Medical School, Cambridge, MA L.A. OPLER: Department of Psychology, Long Island University, Brooklyn, NY M.G.A. OPLER: ProPhase LLC, Department of Psychiatry, New York University School of Medicine, New York, NY, and Department of Psychiatry, Columbia University, New York, NY LEVITAN: Synergy Psychological, Sierra Madre, CA PRATTS: St Joseph's Hospital Health Center, Syracuse, NY MUENZENMAIER: Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY SHELLEY: Bronx Psychiatric Center, Bronx, NY GRENNAN: ProPhase LLC, New York, NY  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 1527-4160 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26554331 Approved no  
  Call Number UU @ jana.mullerova @ Serial 42171  
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Author (up) Frankfurt, S.; Anders, S.L.; James, L.M.; Engdahl, B.; Winskowski, A.M. url  doi
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  Title Evaluating the dimensionality of PTSD in a sample of OIF/OEF veterans Type Journal Article
  Year 2015 Publication Psychological Trauma : Theory, Research, Practice and Policy Abbreviated Journal Psychol Trauma  
  Volume 7 Issue 5 Pages 430-436  
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  Abstract Both categorical and dimensional models of mental disorders, including posttraumatic stress disorder (PTSD), are useful for diagnostic and heuristic purposes; however, few empirical studies have compared categorical and dimensional models of PTSD side-by-side or compared these models to a hybrid (dimensional and categorical) model. In the present study, the dimensionality of PTSD was examined by fitting latent profile analytic, confirmatory factor analytic, and factor mixture models in 271 Operation Iraqi Freedom/Operation Enduring Freedom veterans 6 months after return from deployment. Latent profile analysis was used to identify subgroups of individuals with similar PTSD symptom profiles and predictors of subgroup membership, confirmatory factor analysis was used to identify the underlying continuous structure of PTSD in this sample, and factor mixture modeling was used to test whether a hybrid categorical and continuous model of PTSD best fit our sample. A factor mixture model consisting of a 4-factor dysphoria model of PTSD with 2 classes characterized by low and moderate symptom severity was the best-fitting model. Dissociation and deployment concerns emerged as significant predictors of membership in the moderate symptoms class. Implications for PTSD diagnostic conceptualization and treatment planning are discussed.  
  Address Brain Science Center, Minneapolis Veterans Affairs Medical Center  
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  Series Volume Series Issue Edition  
  ISSN 1942-969X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25793318 Approved no  
  Call Number UU @ jana.mullerova @ Serial 42190  
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Author (up) Frewen, P.; Hegadoren, K.; Coupland, N.J.; Rowe, B.H.; Neufeld, R.W.J.; Lanius, R. url  doi
openurl 
  Title Trauma-Related Altered States of Consciousness (TRASC) and Functional Impairment I: Prospective Study in Acutely Traumatized Persons Type Journal Article
  Year 2015 Publication Journal of Trauma & Dissociation : the Official Journal of the International Society for the Study of Dissociation (ISSD) Abbreviated Journal J Trauma Dissociation  
  Volume 16 Issue 5 Pages 500-519  
  Keywords 4-D model; childhood abuse and neglect; dissociation; posttraumatic stress disorder; trauma-related altered states of consciousness  
  Abstract A theoretical framework referred to as a 4-D model has been described for classifying posttraumatic stress symptoms into those potentially occurring within normal waking consciousness (NWC) versus those thought to intrinsically exemplify dissociative experiences, specifically, trauma-related altered states of consciousness (TRASC). As a further test of this theoretical distinction, this prospective study evaluated whether TRASC and NWC forms of distress incrementally and prospectively predicted functional impairment at 6 and 12 weeks following presentation at hospital emergency departments in the acute aftermath of traumatic events in 180 persons. Establishing the clinical significance of both TRASC and NWC-distress symptoms, we found that 6-week markers of TRASC and NWC-distress independently predicted 12-week self-reported levels of social and occupational impairment. We also observed broad support for various predictions of the 4-D model except that, in contrast with hypotheses, childhood trauma history was generally more strongly correlated with symptoms of NWC-distress than with TRASC. Future research directions are discussed.  
  Address f Department of Psychiatry and Graduate Program in Neuroscience , Western University , London , Ontario , Canada  
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  Series Volume Series Issue Edition  
  ISSN 1529-9732 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26378486 Approved no  
  Call Number UU @ jana.mullerova @ Serial 42174  
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Author (up) Frewen, P.A.; Brown, M.F.D.; Steuwe, C.; Lanius, R.A. url  openurl
  Title Latent profile analysis and principal axis factoring of the DSM-5 dissociative subtype Type Journal Article
  Year 2015 Publication European Journal of Psychotraumatology Abbreviated Journal Eur J Psychotraumatol  
  Volume 6 Issue Pages 26406  
  Keywords Posttraumatic stress disorder; dissociation; dissociative subtype; psychological trauma; trauma-related altered states of consciousness  
  Abstract OBJECTIVE: A dissociative subtype has been recognized based on the presence of experiences of depersonalization and derealization in relation to DSM-IV posttraumatic stress disorder (PTSD). However, the dissociative subtype has not been assessed in a community sample in relation to the revised DSM-5 PTSD criteria. Moreover, the 20-item PTSD Checklist for DSM-5 (PCL-5) currently does not assess depersonalization and derealization. METHOD: We therefore evaluated two items for assessing depersonalization and derealization in 557 participants recruited online who endorsed PTSD symptoms of at least moderate severity on the PCL-5. RESULTS: A five-class solution identified two PTSD classes who endorsed dissociative experiences associated with either 1) severe or 2) moderate PTSD symptom severity (D-PTSD classes). Those in the severe dissociative class were particularly likely to endorse histories of childhood physical and sexual abuse. A principal axis factor analysis of the symptom list identified six latent variables: 1) Reexperiencing, 2) Emotional Numbing/Anhedonia, 3) Dissociation, 4) Negative Alterations in Cognition & Mood, 5) Avoidance, and 6) Hyperarousal. CONCLUSIONS: The present results further support the presence of a dissociative subtype within the DSM-5 criteria for PTSD.  
  Address Graduate Program in Neuroscience, Western University, London, Ontario, Canada  
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  ISSN 2000-8066 ISBN Medium  
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  Notes PMID:25854673 Approved no  
  Call Number UU @ jana.mullerova @ Serial 42188  
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Author (up) Gadagkar, R. openurl 
  Title How should biologists engage with controversial mathematical theory? Type Journal Article
  Year 2015 Publication Abbreviated Journal Current Science  
  Volume 108 Issue 10 Pages 1869-1873  
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  Call Number CES @ dilipnaidu.gt @ Serial 43034  
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Author (up) Gilding, M.; Gregory, S.; Cosson, B. doi  openurl
  Title Motives and Outcomes in Family Business Succession Planning Type Journal Article
  Year 2015 Publication Entrepreneurship Theory and Practice Abbreviated Journal Entrepreneurship Theory and Practice  
  Volume 39 Issue 2 Pages 299-312  
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  Abstract The family business succession planning literature routinely assumes two main motives on the part of incumbents: family business continuity across generations and family harmony. The cross-tabulation of these motives produces a typology consisting of four distinct combinations of motives for succession planning. In turn, these combinations suggest four outcomes of succession planning, framed as institutionalization, implosion, imposition, and individualization. The first two outcomes—institutionalization and implosion—are fully elucidated in the literature. The other two—imposition and individualization—are routinely overlooked. The proposed typology highlights the repertoire of motives that inform succession planning, and how they promote distinct succession outcomes.  
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  ISSN 1540-6520 ISBN Medium  
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  Notes Approved no  
  Call Number ATM @ robstephens13 @ Serial 41574  
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Author (up) Gros, A.; Syvannarath, V.; Lamrani, L.; Ollivier, V.; Loyau, S.; Goerge, T.; Nieswandt, B.; Jandrot-Perrus, M.; Ho-Tin-Noé, B. openurl 
  Title Single platelets seal neutrophil-induced vascular breaches via GPVI during immune complex-mediated inflammation in mice Type Journal Article
  Year 2015 Publication Abbreviated Journal Blood  
  Volume Issue Pages  
  Keywords Confocal; IVM; Microscopy; Model: Mouse; Mouse; Multiphoton; Thrombosis  
  Abstract Platelets protect vascular integrity during inflammation. Recent evidence suggests that this action is independent of thrombus formation and requires the engagement of glycoprotein VI (GPVI), but it remains unclear how platelets prevent inflammatory bleeding. We investigated whether platelets and GPVI act primarily by preventing detrimental effects of neutrophils using models of immune complex(IC)-mediated inflammation in mice immuno-depleted in platelets and/or neutrophils or deficient in GPVI. Depletion of neutrophils prevented bleeding in thrombocytopenic and GPVI-/- mice during IC-mediated dermatitis. GPVI deficiency did not modify neutrophil recruitment, which was however reduced by thrombocytopenia. Neutrophil cytotoxic activities were reduced in thrombocytopenic and GPVI-/- mice during IC-mediated inflammation. Intravital microscopy revealed that in this setting, intravascular binding sites for platelets were exposed by neutrophils, and GPVI supported the recruitment of individual platelets to these spots. Furthermore, the platelet secretory response accompanying IC-mediated inflammation was partly mediated by GPVI and blocking of GPVI signalling impaired the vasculoprotective action of platelets. Together, our results show that GPVI plays a dual role in inflammation by enhancing neutrophil damaging activities while supporting the activation and hemostatic adhesion of single platelets to neutrophil-induced vascular breaches.  
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  Notes Approved no  
  Call Number UofT @ mathieu.lemaire @ Serial 45622  
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Author (up) Guenther, C.; Oertel, S.; Walgenbach, P. doi  openurl
  Title It's All About Timing: Age-Dependent Consequences of Founder Exits and New Member Additions Type Journal Article
  Year 2015 Publication Entrepreneurship Theory and Practice Abbreviated Journal Entrepreneurship Theory and Practice  
  Volume Issue Pages n/a-n/a  
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  Abstract This article explores the effects of changes in the initial venture team on a firm's failure risk by considering firm age. The results show that founder exits are especially critical for firm survival in the first years of a firm's existence, whereas the entry of a new team member is more beneficial in later years. Further, an investigation of multiple founder exits shows that the time that elapses between two exits has a U-shaped relationship with a firm's hazard risk. Discussing these findings in terms of imprinting and the liability of newness, we contribute to a more comprehensive understanding of venture team dynamics and firm survival.  
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  ISSN 1540-6520 ISBN Medium  
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  Notes Approved no  
  Call Number ATM @ robstephens13 @ Serial 41436  
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