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Author Allison, T.H.; Davis, B.C.; Short, J.C.; Webb, J.W.
Title Crowdfunding in a Prosocial Microlending Environment: Examining the Role of Intrinsic Versus Extrinsic Cues Type Journal Article
Year 2015 Publication Entrepreneurship Theory and Practice Abbreviated Journal Entrepreneurship Theory and Practice
Volume 39 Issue 1 Pages 53-73
Keywords
Abstract Microloans garnered from crowdfunding provide an important source of financial capital for nascent entrepreneurs. Drawing on cognitive evaluation theory, we assess how linguistic cues known to affect underlying motivation can frame entrepreneurial narratives either as a business opportunity or as an opportunity to help others. We examine how this framing affects fundraising outcomes in the context of prosocial lending and conduct our analysis on a sample of microloans made to over 36,000 entrepreneurs in 51 countries via an online crowdfunding platform. We find that lenders respond positively to narratives highlighting the venture as an opportunity to help others, and less positively when the narrative is framed as a business opportunity.
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Series Editor Series Title Abbreviated Series Title
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ISSN 1540-6520 ISBN Medium
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Call Number ATM @ robstephens13 @ Serial 41433
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Author Allum, F.; Shao, X.; Guénard, F.; Simon, M.M.; Busche, S.; Caron, M.; Lambourne, J.; Lessard, J.; Tandre, K.; Hedman, Å.K.; Kwan, T.; Ge, B.; Multiple, T.H.E.R.C.; Rönnblom, L.; McCarthy, M.I.; Deloukas, P.; Richmond, T.; Burgess, D.; Spector, T.D.; Tchernof, A.; Marceau, S.; Lathrop, M.; Vohl, M.C.; Pastinen, T.; Grundberg, E.
Title Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants Type Journal Article
Year 2015 Publication Abbreviated Journal Nat Commun
Volume 6 Issue Pages 7211
Keywords
Abstract Most genome-wide methylation studies (EWAS) of multifactorial disease traits use targeted arrays or enrichment methodologies preferentially covering CpG-dense regions, to characterize sufficiently large samples. To overcome this limitation, we present here a new customizable, cost-effective approach, methylC-capture sequencing (MCC-Seq), for sequencing functional methylomes, while simultaneously providing genetic variation information. To illustrate MCC-Seq, we use whole-genome bisulfite sequencing on adipose tissue (AT) samples and public databases to design AT-specific panels. We establish its efficiency for high-density interrogation of methylome variability by systematic comparisons with other approaches and demonstrate its applicability by identifying novel methylation variation within enhancers strongly correlated to plasma triglyceride and HDL-cholesterol, including at CD36. Our more comprehensive AT panel assesses tissue methylation and genotypes in parallel at ∼4 and ∼3 M sites, respectively. Our study demonstrates that MCC-Seq provides comparable accuracy to alternative approaches but enables more efficient cataloguing of functional and disease-relevant epigenetic and genetic variants for large-scale EWAS.
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Series Editor Series Title Abbreviated Series Title
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ISSN 2041-1723 ISBN Medium
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Notes Approved no
Call Number UofT @ mathieu.lemaire @ Serial 45631
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Author Alsady, M.; Baumgarten, R.; Deen, P.M.; de Groot, T.
Title Lithium in the Kidney: Friend and Foe Type Journal Article
Year 2015 Publication Abbreviated Journal J Am Soc Nephrol
Volume Issue Pages
Keywords Nephrology
Abstract Trace amounts of lithium are essential for our physical and mental health, and administration of lithium has improved the quality of life of millions of patients with bipolar disorder for >60 years. However, in a substantial number of patients with bipolar disorder, long-term lithium therapy comes at the cost of severe renal side effects, including nephrogenic diabetes insipidus and rarely, ESRD. Although the mechanisms underlying the lithium-induced renal pathologies are becoming clearer, several recent animal studies revealed that short-term administration of lower amounts of lithium prevents different forms of experimental AKI. In this review, we discuss the knowledge of the pathologic and therapeutic effects of lithium in the kidney. Furthermore, we discuss the underlying mechanisms of these seemingly paradoxical effects of lithium, in which fine-tuned regulation of glycogen synthase kinase type 3, a prime target for lithium, seems to be key. The new discoveries regarding the protective effect of lithium against AKI in rodents call for follow-up studies in humans and suggest that long-term therapy with low lithium concentrations could be beneficial in CKD.
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Series Editor Series Title Abbreviated Series Title
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ISSN 1046-6673 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number UofT @ mathieu.lemaire @ Serial 45624
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Author Amendola, L.M.; Dorschner, M.O.; Robertson, P.D.; Salama, J.S.; Hart, R.; Shirts, B.H.; Murray, M.L.; Tokita, M.J.; Gallego, C.J.; Kim, D.S.; Bennett, J.T.; Crosslin, D.R.; Ranchalis, J.; Jones, K.L.; Rosenthal, E.A.; Jarvik, E.R.; Itsara, A.; Turner, E.H.; Herman, D.S.; Schleit, J.; Burt, A.; Jamal, S.M.; Abrudan, J.L.; Johnson, A.D.; Conlin, L.K.; Dulik, M.C.; Santani, A.; Metterville, D.R.; Kelly, M.; Foreman, A.K.; Lee, K.; Taylor, K.D.; Guo, X.; Crooks, K.; Kiedrowski, L.A.; Raffel, L.J.; Gordon, O.; Machini, K.; Desnick, R.J.; Biesecker, L.G.; Lubitz, S.A.; Mulchandani, S.; Cooper, G.M.; Joffe, S.; Richards, C.S.; Yang, Y.; Rotter, J.I.; Rich, S.S.; O’Donnell, C.J.; Berg, J.S.; Spinner, N.B.; Evans, J.P.; Fullerton, S.M.; Leppig, K.A.; Bennett, R.L.; Bird, T.; Sybert, V.P.; Grady, W.M.; Tabor, H.K.; Kim, J.H.; Bamshad, M.J.; Wilfond, B.; Motulsky, A.G.; Scott, C.R.; Pritchard, C.C.; Walsh, T.D.; Burke, W.; Raskind, W.H.; Byers, P.; Hisama, F.M.; Rehm, H.; Nickerson, D.A.; Jarvik, G.P.
Title Actionable exomic incidental findings in 6503 participants: challenges of variant classification Type Journal Article
Year 2015 Publication Abbreviated Journal Genome Res
Volume 25 Issue 3 Pages 305-315
Keywords
Abstract Recommendations for laboratories to report incidental findings from genomic tests have stimulated interest in such results. In order to investigate the criteria and processes for assigning the pathogenicity of specific variants and to estimate the frequency of such incidental findings in patients of European and African ancestry, we classified potentially actionable pathogenic single-nucleotide variants (SNVs) in all 4300 European- and 2203 African-ancestry participants sequenced by the NHLBI Exome Sequencing Project (ESP). We considered 112 gene-disease pairs selected by an expert panel as associated with medically actionable genetic disorders that may be undiagnosed in adults. The resulting classifications were compared to classifications from other clinical and research genetic testing laboratories, as well as with in silico pathogenicity scores. Among European-ancestry participants, 30 of 4300 (0.7%) had a pathogenic SNV and six (0.1%) had a disruptive variant that was expected to be pathogenic, whereas 52 (1.2%) had likely pathogenic SNVs. For African-ancestry participants, six of 2203 (0.3%) had a pathogenic SNV and six (0.3%) had an expected pathogenic disruptive variant, whereas 13 (0.6%) had likely pathogenic SNVs. Genomic Evolutionary Rate Profiling mammalian conservation score and the Combined Annotation Dependent Depletion summary score of conservation, substitution, regulation, and other evidence were compared across pathogenicity assignments and appear to have utility in variant classification. This work provides a refined estimate of the burden of adult onset, medically actionable incidental findings expected from exome sequencing, highlights challenges in variant classification, and demonstrates the need for a better curated variant interpretation knowledge base.
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Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 1088-9051 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number UofT @ mathieu.lemaire @ Serial 45831
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Author Andeen, N.K.; Nguyen, T.Q.; Steegh, F.; Hudkins, K.L.; Najafian, B.; Alpers, C.E.
Title The phenotypes of podocytes and parietal epithelial cells may overlap in diabetic nephropathy Type Journal Article
Year 2015 Publication Abbreviated Journal Kidney Int
Volume 88 Issue 5 Pages 1099-1107
Keywords
Abstract Reversal of diabetic nephropathy (DN) has been achieved in humans and mice, but only rarely and under special circumstances. As progression of DN is related to podocyte loss, reversal of DN requires restoration of podocytes. Here, we identified and quantified potential glomerular progenitor cells that could be a source for restored podocytes. DN was identified in 31 human renal biopsy cases and separated into morphologically early or advanced lesions. Markers of podocytes (WT-1, p57), parietal epithelial cells (PECs) (claudin-1), and cell proliferation (Ki-67) were identified by immunohistochemistry. Podocyte density was progressively reduced with DN. Cells marking as podocytes (p57) were present infrequently on Bowman’s capsule in controls, but significantly increased in histologically early DN. Ki-67-expressing cells were identified on the glomerular tuft and Bowman’s capsule in DN, but rarely in controls. Cells marking as PECs were present on the glomerular tuft, particularly in morphologically advanced DN. These findings show evidence of phenotypic plasticity in podocyte and PEC populations and are consistent with studies in the BTBR ob/ob murine model in which reversibility of DN occurs with podocytes potentially regenerating from PEC precursors. Thus, our findings support, but do not prove, that podocytes may regenerate from PEC progenitors in human DN. If so, progression of DN may represent a modifiable net balance between podocyte loss and regeneration.
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Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0085-2538 ISBN Medium
Area Expedition Conference
Notes Approved no
Call Number UofT @ mathieu.lemaire @ Serial 45953
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Author Anderson-Teixeira, K.J.; Davies, S.J.; Bennett, A.C.; Gonzalez-Akre, E.B.; Muller-Landau, H.C.; Joseph Wright, S.; Abu Salim, K.; Almeyda Zambrano, A.M.; Alonso, A.; Baltzer, J.L.; Basset, Y.; Bourg, N.A.; Broadbent, E.N.; Brockelman, W.Y.; Bunyavejchewin, S.; Burslem, D.F.R.P.; Butt, N.; Cao, M.; Cardenas, D.; Chuyong, G.B.; Clay, K.; Cordell, S.; Dattaraja, H.S.; Deng, X.; Detto, M.; Du, X.; Duque, A.; Erikson, D.L.; Ewango, C.E.N.; Fischer, G.A.; Fletcher, C.; Foster, R.B.; Giardina, C.P.; Gilbert, G.S.; Gunatilleke, N.; Gunatilleke, S.; Hao, Z.; Hargrove, W.W.; Hart, T.B.; Hau, B.C.H.; He, F.; Hoffman, F.M.; Howe, R.W.; Hubbell, S.P.; Inman-Narahari, F.M.; Jansen, P.A.; Jiang, M.; Johnson, D.J.; Kanzaki, M.; Kassim, A.R.; Kenfack, D.; Kibet, S.; Kinnaird, M.F.; Korte, L.; Kral, K.; Kumar, J.; Larson, A.J.; Li, Y.; Li, X.; Liu, S.; Lum, S.K.Y.; Lutz, J.A.; Ma, K.; Maddalena, D.M.; Makana, J.-R.; Malhi, Y.; Marthews, T.; Mat Serudin, R.; McMahon, S.M.; McShea, W.J.; Memiaghe, H.R.; Mi, X.; Mizuno, T.; Morecroft, M.; Myers, J.A.; Novotny, V.; de Oliveira, A.A.; Ong, P.S.; Orwig, D.A.; Ostertag, R.; den Ouden, J.; Parker, G.G.; Phillips, R.P.; Sack, L.; Sainge, M.N.; Sang, W.; Sri-ngernyuang, K.; Sukumar, R.; Sun, I.-F.; Sungpalee, W.; Suresh, H.S.; Tan, S.; Thomas, S.C.; Thomas, D.W.; Thompson, J.; Turner, B.L.; Uriarte, M.; Valencia, R.; Vallejo, M.I.; Vicentini, A.; Vrška, T.; Wang, X.; Wang, X.; Weiblen, G.; Wolf, A.; Xu, H.; Yap, S.; Zimmerman, J.
Title CTFS-ForestGEO: a worldwide network monitoring forests in an era of global change Type Journal Article
Year 2015 Publication Abbreviated Journal Global Change Biology
Volume 21 Issue 2 Pages 528-549
Keywords biodiversity; Center for Tropical Forest Science (CTFS); climate change; demography; forest dynamics plot; Forest Global Earth Observatory (ForestGEO); long-term monitoring; spatial analysis
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ISSN 1365-2486 ISBN Medium
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Call Number CES @ dilipnaidu.gt @ Serial 43015
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Author Andersson, R.; Sandelin, A.; Danko, C.G.
Title A unified architecture of transcriptional regulatory elements Type Journal Article
Year 2015 Publication Abbreviated Journal Trends Genet
Volume 31 Issue 8 Pages 426-433
Keywords
Abstract Gene expression is precisely controlled in time and space through the integration of signals that act at gene promoters and gene-distal enhancers. Classically, promoters and enhancers are considered separate classes of regulatory elements, often distinguished by histone modifications. However, recent studies have revealed broad similarities between enhancers and promoters, blurring the distinction: active enhancers often initiate transcription, and some gene promoters have the potential to enhance transcriptional output of other promoters. Here, we propose a model in which promoters and enhancers are considered a single class of functional element, with a unified architecture for transcription initiation. The context of interacting regulatory elements and the surrounding sequences determine local transcriptional output as well as the enhancer and promoter activities of individual elements.
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ISSN 0168-9525 ISBN Medium
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Notes Approved no
Call Number UofT @ mathieu.lemaire @ Serial 45626
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Author Andrade-Oliveira, V.; Amano, M.T.; Correa-Costa, M.; Castoldi, A.; Felizardo, R.J.; de Almeida, D.C.; Bassi, E.J.; Moraes-Vieira, P.M.; Hiyane, M.I.; Rodas, A.C.; Peron, J.P.; Aguiar, C.F.; Reis, M.A.; Ribeiro, W.R.; Valduga, C.J.; Curi, R.; Vinolo, M.A.; Ferreira, C.M.; Câmara, N.O.
Title Gut Bacteria Products Prevent AKI Induced by Ischemia-Reperfusion Type Journal Article
Year 2015 Publication Abbreviated Journal J Am Soc Nephrol
Volume 26 Issue 8 Pages 1877-1888
Keywords
Abstract Short-chain fatty acids (SCFAs) are fermentation end products produced by the intestinal microbiota and have anti-inflammatory and histone deacetylase-inhibiting properties. Recently, a dual relationship between the intestine and kidneys has been unraveled. Therefore, we evaluated the role of SCFA in an AKI model in which the inflammatory process has a detrimental role. We observed that therapy with the three main SCFAs (acetate, propionate, and butyrate) improved renal dysfunction caused by injury. This protection was associated with low levels of local and systemic inflammation, oxidative cellular stress, cell infiltration/activation, and apoptosis. However, it was also associated with an increase in autophagy. Moreover, SCFAs inhibited histone deacetylase activity and modulated the expression levels of enzymes involved in chromatin modification. In vitro analyses showed that SCFAs modulated the inflammatory process, decreasing the maturation of dendritic cells and inhibiting the capacity of these cells to induce CD4(+) and CD8(+) T cell proliferation. Furthermore, SCFAs ameliorated the effects of hypoxia in kidney epithelial cells by improving mitochondrial biogenesis. Notably, mice treated with acetate-producing bacteria also had better outcomes after AKI. Thus, we demonstrate that SCFAs improve organ function and viability after an injury through modulation of the inflammatory process, most likely via epigenetic modification.
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ISSN 1046-6673 ISBN Medium
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Call Number UofT @ mathieu.lemaire @ Serial 45839
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Author Aoki-Kinoshita, K.F.
Title Glycoinformatics: Overview Type Book Chapter
Year 2015 Publication Glycoinformatics: Overview Abbreviated Journal
Volume Glycoscience: Biology and Medicine Issue Pages 185-192
Keywords
Abstract Because of the many different glycan-related databases now publicly available, a number of different glycan structure representations are used to graphically and textually display glycans structures. This overview provides an easy reference to each representation format as well as links to several major databases and web resources that may be useful for glycobiologists. Many of the major databases, glycan sequence and structure representation formats, and tools that are currently available and used in the glycoscience field will be …
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Publisher Springer Place of Publication Tokyo Editor Endo, T.; Seeberger, P.H.; Hart, G.W.; Wong, C.-H.; Taniguchi, N.
Language Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN 978-4-431-54836-2 Medium
Area Expedition Conference
Notes Approved no
Call Number UofT @ mathieu.lemaire @ Serial 45629
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Author Ariceta, G.; Lara, E.; Camacho, J.A.; Oppenheimer, F.; Vara, J.; Santos, F.; Muñoz, M.A.; Cantarell, C.; Gil Calvo, M.; Romero, R.; Valenciano, B.; García-Nieto, V.; Sanahuja, M.J.; Crespo, J.; Justa, M.L.; Urisarri, A.; Bedoya, R.; Bueno, A.; Daza, A.; Bravo, J.; Llamas, F.; Jiménez Del Cerro, L.A.
Title Cysteamine (Cystagon®) adherence in patients with cystinosis in Spain: successful in children and a challenge in adolescents and adults Type Journal Article
Year 2015 Publication Abbreviated Journal Nephrol Dial Transplant
Volume 30 Issue 3 Pages 475-480
Keywords
Abstract BACKGROUND: Cysteamine has improved survival and prognosis in cystinosis. Increasing numbers of patients reach adulthood and face new challenges such as compliance that wanes over time. The aim of this study was to evaluate adherence to cysteamine treatment in a group of cystinotic patients in Spain in an attempt to identify potential therapy pitfalls and improve the overall care of affected individuals. Despite the impact of cysteamine on prognosis, there is a paucity of data regarding adherence. METHOD: Thirty-four cystinotic patients (21 male) 38% ≥18 years were enrolled in a voluntary, anonymous survey. Replies were obtained from patients (15/34), mothers (11/34), fathers (4/34) and both parents (4/34). RESULTS: Patient age (median and interquartile range) at diagnosis was 1 year (0.57-1), and patient age at Cystagon® initiation was also 1 year (0.8-1.8). Sixteen (47%) were kidney transplant (KTx) recipients; six were retransplanted. Age at first KTx 10 years (8.7-13.7). Patient understanding of multiorgan involvement in cystinosis: 4.1 organs reported; eye 97% and kidney 91%. Cysteamine was given by mother (100%) and father (83%) in <11 year olds, or self-administered (94%) in ≥11 year olds. Four daily doses in 89% versus 56% in <11 year olds or ≥11 year olds, with fixed schedule in 94% versus 50% in <11 or ≥11 year olds and progressive loss of reminders over time. Furthermore, 44% complained of unpleasant smell. Motivation for treatment compliance was 100% versus 40% in <11 versus ≥11 year olds, respectively. Disease impact in patients <18 years is as follows: school (29%), social (14%), ‘feeling different’ (10%); in patients ≥18 years: ‘feeling different’ (62%), professional (39%) and job absenteeism (31%). Referring physician: paediatric nephrologist (94%) and nephrologist (63%) in <11 versus ≥11 year olds. Ophthalmological follow-up: 83% versus 38% in <11 versus ≥11 year olds. Patient opinion of physician expertise: paediatric nephrologist (94%) and nephrologist (44%). New treatment options (65%) and better information (42%) were demanded to improve adherence. CONCLUSION: Treatment with Cystagon is effective in young patients. However, adherence diminishes over time in adolescents and adults despite disease impact. Strategies such as better information on the disease, patient self-care promotion and facilitated transition to adult healthcare services are required to improve compliance and the clinical management of cystinosis.
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ISSN 0931-0509 ISBN Medium
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Call Number UofT @ mathieu.lemaire @ Serial 45856
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