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Author isbn  openurl
  Title Mechanobiology of the Endothelium Type Book Whole
  Year 2015 Publication Abbreviated Journal  
  Volume Issue Pages  
  Keywords  
  Abstract The endothelium is an excellent example of where biology meets physics and engineering. It must convert mechanical forces into chemical signals to maintain homeostasis. It also controls the immune response, drug delivery through the vasculature, and cancer metastasis. Basic understanding of these processes is starting to emerge and the knowledge gained from research is now being used in applications from drug delivery to imaging modalities. This book reviews current knowledge in mechanobiology of the endothelium and its implications for the development of theranostic devices.  
  Address  
  Corporate Author Thesis  
  Publisher CRC Press Place of Publication Editor  
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  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN 9781482207255 Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number UofT @ mathieu.lemaire @ Serial 45932  
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Author Abbasi, F.; Azizi, F.; Javaheri, M.; Mosallanejad, A.; Ebrahim-Habibi, A.; Ghafouri-Fard, S. url  openurl
  Title Segregation of a novel homozygous 6 nucleotide deletion in GLUT2 gene in a Fanconi-Bickel syndrome family Type Journal Article
  Year 2015 Publication Abbreviated Journal Gene  
  Volume 557 Issue 1 Pages 103-105  
  Keywords  
  Abstract Fanconi-Bickel syndrome (FBS) is a rare autosomal recessive disorder characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, impaired utilization of glucose and galactose, rickets, and severe short stature. It has been shown to be caused by mutations in GLUT2 gene, a member of the facilitative glucose transporter family. Here, we report an Iranian family with 2 affected siblings. The clinical findings in the patients include developmental delay, failure to thrive, hepatomegaly, enlarged kidneys and rickets. A novel 6 nucleotide deletion (c.10611066del6, p.V355S356del2) is shown to be segregated with the disease in this family.  
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  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0378-1119 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number UofT @ mathieu.lemaire @ Serial 45434  
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Author Abduev, A.; Akmedov, A.; Asvarov, A.; Chiolerio, A. url  openurl
  Title A revised growth model for transparent conducting Ga doped ZnO films: Improving crystallinity by means of buffer layers Type Journal Article
  Year 2015 Publication Abbreviated Journal Plasma Processes and Polymers  
  Volume 12 Issue 8 Pages 725-733  
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  Notes Cited By :3; Export Date: 2 November 2016 Approved no  
  Call Number IIT-CSF @ alessandro.chiolerio @ Serial 42780  
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Author Abraham, G.; Inouye, M. url  openurl
  Title Genomic risk prediction of complex human disease and its clinical application Type Journal Article
  Year 2015 Publication Abbreviated Journal Curr Opin Genet Dev  
  Volume 33 Issue Pages 10-16  
  Keywords  
  Abstract Recent advances in genome-wide association studies have stimulated interest in the genomic prediction of disease risk, potentially enabling individual-level risk estimates for early intervention and improved diagnostic procedures. Here, we review recent findings and approaches to genomic prediction model construction and performance, then contrast the potential benefits of such models in two complex human diseases, aiding diagnosis in celiac disease and prospective risk prediction for cardiovascular disease. Early indications are that optimal application of genomic risk scores will differ substantially for each disease depending on underlying genetic architecture as well as current clinical and public health practice. As costs decline, genomic profiles become common, and popular understanding of risk and its communication improves, genomic risk will become increasingly useful for the individual and the clinician.  
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  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0959-437x ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number UofT @ mathieu.lemaire @ Serial 45437  
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Author ACMG, B. of D. url  openurl
  Title ACMG policy statement: updated recommendations regarding analysis and reporting of secondary findings in clinical genome-scale sequencing Type Journal Article
  Year 2015 Publication Abbreviated Journal Genet Med  
  Volume 17 Issue 1 Pages 68-69  
  Keywords  
  Abstract DISCLAIMER: These recommendations are designed primarily as an educational resource for medical geneticists and other health-care providers to help them provide quality medical genetics services. Adherence to these recommendations does not necessarily ensure a successful medical outcome. These recommendations should not be considered inclusive of all proper procedures and tests or exclusive of other procedures and tests that are reasonably directed to obtaining the same results. In determining the propriety of any specific procedure or test, geneticists and other clinicians should apply their own professional judgment to the specific clinical circumstances presented by the individual patient or specimen. It may be prudent, however, to document in the patient’s record the rationale for any significant deviation from these recommendations.  
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  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1098-3600 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number UofT @ mathieu.lemaire @ Serial 45436  
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Author Adamek, M.; Opelz, G.; Klein, K.; Morath, C.; Tran, T.H. url  openurl
  Title A fast and simple method for detecting and quantifying donor-derived cell-free DNA in sera of solid organ transplant recipients as a biomarker for graft function Type Journal Article
  Year 2015 Publication Abbreviated Journal Clin Chem Lab Med  
  Volume Issue Pages  
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  Abstract BACKGROUND: Timely detection of graft rejection is an important issue in the follow-up care after solid organ transplantation. Until now, biopsy has been considered the “gold standard” in the diagnosis of graft rejection. However, non-invasive tests such as monitoring the levels of cell-free DNA (cfDNA) as a sensitive biomarker for graft integrity have attracted increasing interest. The rationale of this approach is that a rejected organ will lead to a significant release of donor-derived cfDNA, which can be detected in the serum of the transplant recipient. METHODS: We have developed a novel quantitative real-time PCR (qPCR) approach for detecting an increase of donor-derived cfDNA in the recipient’s serum. Common insertion/deletion (InDel) genetic polymorphisms, which differ between donor and recipient, are targeted in our qPCR assay. In contrast to some other strategies, no specific donor/recipient constellations such as certain gender combinations or human leukocyte antigen (HLA) discrepancies are required for the application of our test. RESULTS: The method was first validated with serial dilutions of serum mixtures obtained from healthy blood donors and then used to determine donor-derived cfDNA levels in patients’ sera within the first 3 days after their kidney transplantation had been performed. CONCLUSIONS: Our method represents a universally applicable, simple and cost-effective tool which can potentially be used to detect graft dysfunction in transplant recipients.  
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  ISSN 1434-6621 ISBN Medium  
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  Notes Approved no  
  Call Number UofT @ mathieu.lemaire @ Serial 45414  
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Author Adebayo, D.; Morabito, V.; Davenport, A.; Jalan, R. url  openurl
  Title Renal dysfunction in cirrhosis is not just a vasomotor nephropathy Type Journal Article
  Year 2015 Publication Abbreviated Journal Kidney Int  
  Volume 87 Issue 3 Pages 509-515  
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  Abstract The short-term mortality of cirrhotic patients who develop renal dysfunction remains unacceptably high, and as such the treatment of this condition is an unmet need. Although features of kidney injury are well recognized in these patients, the pathophysiology is complex and not completely understood. Improved understanding of the pathophysiological mechanisms involved in renal dysfunction occurring on a background of cirrhosis is key to developing effective treatment strategies to improve survival. Renal dysfunction due to hepatorenal syndrome (HRS) is characteristic of cirrhosis. Our current understanding is that HRS is functional in nature and occurs as a consequence of hemodynamic changes associated with portal hypertension. However, there is evidence in the literature suggesting that, histologically, the kidneys are not always normal in the vast majority of patients who present with renal dysfunction on the background of cirrhosis. Furthermore, there is emerging data implicating nonvasomotor mechanisms in the pathophysiology of renal dysfunction in cirrhosis. This mini-review aims to present the evidence suggesting that factors other than hemodynamic dysregulation have an important role in the development of this major complication for patients with progressive cirrhosis.  
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  Series Volume Series Issue Edition  
  ISSN 0085-2538 ISBN Medium  
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  Notes Approved no  
  Call Number UofT @ mathieu.lemaire @ Serial 45609  
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Author Adomdza, G.K. doi  openurl
  Title Choosing Between a Student-Run and Professionally Managed Venture Accelerator Type Journal Article
  Year 2015 Publication Entrepreneurship Theory and Practice Abbreviated Journal Entrepreneurship Theory and Practice  
  Volume Issue Pages n/a-n/a  
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  Abstract This case presents challenges facing a student-run venture accelerator at a major university in the United States. The student-run model has attracted much media attention for its uniqueness, but it has also raised questions about its sustainability. Signals from a new dean, not invested in the student model, are putting much pressure on the student-chief executive officer to change course—to tweak the student-run model and fight for its future or cave in to pressures to “professionalize” it and let students take a backseat in management. The case highlights challenges in entrepreneurial leadership of a student-run accelerator at the point of initial growth.  
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  Series Volume Series Issue Edition  
  ISSN 1540-6520 ISBN Medium  
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  Notes Approved no  
  Call Number ATM @ robstephens13 @ Serial 41235  
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Author Afshinnekoo, E.; Meydan, C.; Chowdhury, S.; Jaroudi, D.; Boyer, C.; Bernstein, N.; Maritz, J.M.; Reeves, D.; Gandara, J.; Chhangawala, S.; Ahsanuddin, S.; Simmons, A.; Nessel, T.; Sundaresh, B.; Pereira, E.; Jorgensen, E.; Kolokotronis, S.O.; Kirchberger, N.; Garcia, I.; Gandara, D.; Dhanraj, S.; Nawrin, T.; Saletore, Y.; Alexander, N.; Vijay, P.; Hénaff, E.M.; Zumbo, P.; Walsh, M.; O’Mullan, G.D.; Tighe, S.; Dudley, J.T.; Dunaif, A.; Ennis, S.; O’Halloran, E.; Magalhaes, T.R.; Boone, B.; Jones, A.L.; Muth, T.R.; Paolantonio, K.S.; Alter, E.; Schadt, E.E.; Garbarino, J.; Prill, R.J.; Carlton, J.M.; Levy, S.; Mason, C.E. url  openurl
  Title Geospatial Resolution of Human and Bacterial Diversity with City-Scale Metagenomics Type Journal Article
  Year 2015 Publication Abbreviated Journal Cell Syst  
  Volume 1 Issue Pages 72-87  
  Keywords Aop  
  Abstract The panoply of microorganisms and other species present in our environment influence human health and disease, especially in cities, but have not been profiled with metagenomics at a city-wide scale. We sequenced DNA from surfaces across the entire New York City (NYC) subway system, the Gowanus Canal, and public parks. Nearly half of the DNA (48%) does not match any known organism; identified organisms spanned 1,688 bacterial, viral, archaeal, and eukaryotic taxa, which were enriched for harmless genera associated with skin (e.g., Acinetobacter). Predicted ancestry of human DNA left on subway surfaces can recapitulate U.S. Census demographic data, and bacterial signatures can reveal a station’s history, such as marine-associated bacteria in a hurricane-flooded station. Some evidence of pathogens was found (Bacillus anthracis), but a lack of reported cases in NYC suggests that the pathogens represent a normal, urban microbiome. This baseline metagenomic map of NYC could help long-term disease surveillance, bioterrorism threat mitigation, and health management in the built environment of cities.  
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  ISSN 2405-4712 ISBN Medium  
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  Notes Approved no  
  Call Number UofT @ mathieu.lemaire @ Serial 45849  
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Author Agarwal, I.; Karanth, K.P. url  openurl
  Title A phylogeny of the only ground-dwelling radiation of Cyrtodactylus (Squamata, Gekkonidae): diversification of Geckoella across peninsular India and Sri Lanka Type Journal Article
  Year 2015 Publication Abbreviated Journal Molecular Phylogenetics and Evolution  
  Volume 82, Part A Issue Pages 193-199  
  Keywords Aridification; cryptic species; historical biogeography; Mid-Miocene climatic optimum  
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  Series Volume Series Issue Edition  
  ISSN 1055-7903 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number CES @ dilipnaidu.gt @ Serial 43068  
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