toggle visibility Search & Display Options

Select All    Deselect All
 |   | 
Details
   print
  Records Links
Author Gulbahar, O.; Konca Degertekin, C.; Akturk, M.; Yalcin, M.M.; Kalan, I.; Atikeler, G.F.; Altinova, A.E.; Yetkin, I.; Arslan, M.; Toruner, F. url  doi
openurl 
  Title A Case With Immunoassay Interferences in the Measurement of Multiple Hormones Type Journal Article
  Year 2015 Publication The Journal of Clinical Endocrinology and Metabolism Abbreviated Journal J Clin Endocrinol Metab  
  Volume 100 Issue 6 Pages 2147-2153  
  Keywords Adult; Antibodies, Heterophile/*blood; *Artifacts; Cross Reactions; *Diagnostic Techniques, Endocrine/standards; False Positive Reactions; Female; Hormones/*analysis; Humans; Immunoassay/methods; Postpartum Period/blood/immunology  
  Abstract CONTEXT: Commonly used immunoassays are not free from interference, which can be a confounder in the interpretation of test results. We present a case with extremely high multiple hormone levels due to such interference. CASE DESCRIPTION: A 33-year-old woman with no specific symptoms had markedly elevated TSH with normal free T4 and free T3 levels. Repeated measurements revealed discordantly high TSH, ACTH, FSH, PTH, IGF-1, prolactin, beta-human chorionic gonadotropin, and calcitonin levels without the associated clinical pictures. The measurements were repeated with the same patient sample on four different analytical platforms using chemiluminescence immunoassays/electrochemiluminescence immunoassays, and the results were divergent on each platform. Serial dilutions of serum samples revealed nonlinearity, suggesting assay interference. All hormonal measurements were in the normal range when heterophile antibody blocking tubes were used. The serum of the patient was then subjected to polyethylene glycol precipitation. The post-polyethylene glycol recovery resulted in hormone levels in the normal range. The patient did not receive any medications and has been under follow-up without any signs and symptoms for 24 months. CONCLUSIONS: This report illustrates a rare case of falsely elevated hormone levels due to assay interference caused by heterophile antibodies. We point out the importance of a close collaboration between clinicians and the laboratory to avoid unnecessary clinical investigations as well as inappropriate treatments.  
  Address Departments of Biochemistry (O.G., G.F.A.) and Endocrinology and Metabolism (C.K.D., M.A., M.M.Y., I.K., A.E.A., I.Y., M.A., F.T.), Gazi University Faculty of Medicine, 06100 Ankara, Turkey  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0021-972X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25897621 Approved no  
  Call Number QEHB @ isla.wootton @ Serial 42160  
Permanent link to this record
 

 
Author Guttal, V. openurl 
  Title Classroom: Discovering facts – Finding the Longest Day with School Children Type Journal Article
  Year 2015 Publication Abbreviated Journal Resonance  
  Volume 20 Issue 3 Pages 254-259  
  Keywords  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number CES @ dilipnaidu.gt @ Serial 43017  
Permanent link to this record
 

 
Author Hansen, M.; Armour, C.; Wang, L.; Elklit, A.; Bryant, R.A. url  doi
openurl 
  Title Assessing possible DSM-5 ASD subtypes in a sample of victims meeting caseness for DSM-5 ASD based on self-report following multiple forms of traumatic exposure Type Journal Article
  Year 2015 Publication Journal of Anxiety Disorders Abbreviated Journal J Anxiety Disord  
  Volume 31 Issue Pages 84-89  
  Keywords Crime Victims/*psychology; Diagnostic and Statistical Manual of Mental Disorders; Disaster Victims/*psychology; Dissociative Disorders/diagnosis; Female; Humans; Male; Rape/psychology; Self Report; Stress Disorders, Traumatic, Acute/*diagnosis/psychology; Violence/psychology; ASD subtypes; Acute stress disorder; Dsm-5; Icd-11; Latent profile analysis  
  Abstract Acute stress disorder (ASD) was introduced into the DSM-IV to recognize early traumatic responses and as a precursor of PTSD. Although the diagnostic criteria for ASD were altered and structured more similarly to the PTSD definition in DSM-5, only the PTSD diagnosis includes a dissociative subtype. Emerging research has indicated that there also appears to be a highly symptomatic subtype for ASD. However, the specific nature of the subtype is currently unclear. The present study investigates the possible presence of ASD subtypes in a mixed sample of victims meeting caseness for DSM-5 ASD based on self-report following four different types of traumatic exposure (N=472). The results of latent profile analysis revealed a 5-class solution. The highly symptomatic class was marked by high endorsement on avoidance and dissociation compared to the other classes. Findings are discussed in regard to its clinical implications including the implications for the pending the ICD-11 and the recently released DSM-5.  
  Address School of Psychology, University of New South Wales, NSW, Australia  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0887-6185 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25768397 Approved no  
  Call Number UU @ jana.mullerova @ Serial 42192  
Permanent link to this record
 

 
Author Hansen, M.; Hyland, P.; Armour, C.; Shevlin, M.; Elklit, A. url  openurl
  Title Less is more? Assessing the validity of the ICD-11 model of PTSD across multiple trauma samples Type Journal Article
  Year 2015 Publication European Journal of Psychotraumatology Abbreviated Journal Eur J Psychotraumatol  
  Volume 6 Issue Pages 28766  
  Keywords Cfa; Dsm-5; Icd-11; Ptsd; latent structure  
  Abstract BACKGROUND: In the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), the symptom profile of posttraumatic stress disorder (PTSD) was expanded to include 20 symptoms. An alternative model of PTSD is outlined in the proposed 11th edition of the International Classification of Diseases (ICD-11) that includes just six symptoms. OBJECTIVES AND METHOD: The objectives of the current study are: 1) to independently investigate the fit of the ICD-11 model of PTSD, and three DSM-5-based models of PTSD, across seven different trauma samples (N=3,746) using confirmatory factor analysis; 2) to assess the concurrent validity of the ICD-11 model of PTSD; and 3) to determine if there are significant differences in diagnostic rates between the ICD-11 guidelines and the DSM-5 criteria. RESULTS: The ICD-11 model of PTSD was found to provide excellent model fit in six of the seven trauma samples, and tests of factorial invariance showed that the model performs equally well for males and females. DSM-5 models provided poor fit of the data. Concurrent validity was established as the ICD-11 PTSD factors were all moderately to strongly correlated with scores of depression, anxiety, dissociation, and aggression. Levels of association were similar for ICD-11 and DSM-5 suggesting that explanatory power is not affected due to the limited number of items included in the ICD-11 model. Diagnostic rates were significantly lower according to ICD-11 guidelines compared to the DSM-5 criteria. CONCLUSIONS: The proposed factor structure of the ICD-11 model of PTSD appears valid across multiple trauma types, possesses good concurrent validity, and is more stringent in terms of diagnosis compared to the DSM-5 criteria.  
  Address Department of Psychology, National Centre for Psychotraumatology, University of Southern Denmark, Odense M, Denmark  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2000-8066 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26450830 Approved no  
  Call Number UU @ jana.mullerova @ Serial 42172  
Permanent link to this record
 

 
Author Hasan, N.; Ohman, A.W.; Dinulescu, D.M. url  openurl
  Title The promise and challenge of ovarian cancer models Type Journal Article
  Year 2015 Publication Abbreviated Journal Transl Cancer Res  
  Volume 4 Issue 1 Pages 14-28  
  Keywords  
  Abstract The complexity and heterogeneity of ovarian cancer cases are difficult to reproduce in in vitro studies, which cannot adequately elucidate the molecular events involved in tumor initiation and disease metastasis. It has now become clear that, although the multiple histological subtypes of ovarian cancer are being treated with similar surgical and therapeutic approaches, they are in fact characterized by distinct phenotypes, cell of origin, and underlying key genetic and genomic alterations. Consequently, the development of more personalized treatment methodologies, which are aimed at improving patient care and prognosis, will greatly benefit from a better understanding of the key differences between various subtypes. To accomplish this, animal models of all histotypes need to be generated in order to provide accurate in vivo platforms for research and the testing of targeted treatments and immune therapies. Both genetically engineered mouse models (GEMMs) and xenograft models have the ability to further our understanding of key mechanisms facilitating tumorigenesis, and at the same time offer insight into enhanced imaging and treatment modalities. While genetic models may be better suited to examine oncogenic functions and interactions during tumorigenesis, patient-derived xenografts (PDXs) are likely a superior model to assess drug efficacy, especially in concurrent clinical trials, due to their similarity to the tumors from which they are derived. Genetic and avatar models possess great clinical utility and have both benefits and limitations. Additionally, the laying hen model, which spontaneously develops ovarian tumors, has inherent advantages for the study of epithelial ovarian cancer (EOC) and recent work champions this model especially when assessing chemoprevention strategies. While high-grade ovarian serous tumors are the most prevalent form of EOC, rarer ovarian cancer variants, such as small cell ovarian carcinoma of the hypercalcemic type and transitional cell carcinoma, or non-epithelial tumors, including germ cell tumors, will also benefit from the generation of improved models to advance our understanding of tumorigenic mechanisms and the development of selective therapeutic options.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number UofT @ ankit.sinha @ Serial 45119  
Permanent link to this record
 

 
Author Hauswald, H.; Hack, A.; Kellermanns, F.W.; Patzelt, H. doi  openurl
  Title Attracting New Talent to Family Firms: Who Is Attracted and Under What Conditions? Type Journal Article
  Year 2015 Publication Entrepreneurship Theory and Practice Abbreviated Journal Entrepreneurship Theory and Practice  
  Volume Issue Pages n/a-n/a  
  Keywords  
  Abstract In making a decision to enter into a long-term employment relationship with a firm, job seekers often compare their needs and values with the perceived organizational characteristics of the firm. In the case of family firms, the communication of family influence can be a unique factor in shaping beliefs about firm attributes. Family influence is often associated with trustworthiness, security, and stability. However, family influence is also associated with inflexibility and resistance to change. Using the idea of person–organization fit, we hypothesize that although family influence attracts job seekers in general, applicants who value conservation or self-transcendence are particularly attracted, while applicants who emphasize openness to change or self-enhancement are less attracted. Furthermore, we propose that the attractive effects of family influence are more pronounced in more hostile economic environments. We find evidence for our hypotheses using a conjoint experiment and 5,600 assessments of family influence nested within 175 job seekers.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1540-6520 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number ATM @ robstephens13 @ Serial 41747  
Permanent link to this record
 

 
Author Hennin, H.L.; Legagneux, P.; Bêty, J.; Williams, T.D.; Grant Gilchrist, H.; Baker, T.M.; Love, O.P. url  openurl
  Title Pre-breeding energetic management in a mixed-strategy breeder Type Journal Article
  Year 2015 Publication Abbreviated Journal Oecologia  
  Volume 177 Issue 1 Pages 235-243  
  Keywords Breeding threshold; Corticosterone; Energetic management; Energetic metabolites; Mixed-strategy breeder  
  Abstract Integrative biologists have long appreciated that the effective acquisition and management of energy prior to breeding should strongly influence fitness-related reproductive decisions (timing of breeding and reproductive investment). However, because of the difficulty in capturing pre-breeding individuals, and the tendency towards abandonment of reproduction after capture, we know little about the underlying mechanisms of these life-history decisions. Over 10 years, we captured free-living, arctic-breeding common eiders (Somateria mollissima) up to 3 weeks before investment in reproduction. We examined and characterized physiological parameters predicted to influence energetic management by sampling baseline plasma glucocorticoids (i.e., corticosterone), very-low-density lipoprotein (VLDL), and vitellogenin (VTG) for their respective roles in mediating energetic balance, rate of condition gain (physiological fattening rate) and reproductive investment. Baseline corticosterone increased significantly from arrival to the initiation of reproductive investment (period of rapid follicular growth; RFG), and showed a positive relationship with body mass, indicating that this hormone may stimulate foraging behaviour to facilitate both fat deposition and investment in egg production. In support of this, we found that VLDL increased throughout the pre-breeding period, peaking as predicted during RFG. Female eiders exhibited unprecedentedly high levels of VTG well before their theoretical RFG period, a potential strategy for pre-emptively depositing available protein stores into follicles while females are simultaneously fattening. This study provides some of the first data examining the temporal dynamics and interaction of the energetic mechanisms thought to be at the heart of individual variation in reproductive decisions and success in many vertebrate species. © 2014, Springer-Verlag Berlin Heidelberg.  
  Address Environment Canada, National Wildlife Research Centre, Carleton University, Ottawa, ON, Canada  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Cited By :1; Export Date: 17 March 2016 Approved no  
  Call Number McgGll @ elizabethburgess @ Serial 42531  
Permanent link to this record
 

 
Author Holterbach, L.; Baumann, C.; Andreani, B.; Desre, D.; Auxemery, Y. url  doi
openurl 
  Title [Correlation between specific and nonspecific posttraumatic stress disorder symptoms with healthcare consumption among 340 French soldiers] Type Journal Article
  Year 2015 Publication L'Encephale Abbreviated Journal Encephale  
  Volume 41 Issue 5 Pages 444-453  
  Keywords Army; Armees; Consommation de soins; Detection; Depistage; Epidemiology; Healthcare consumption; Militaires; Pcls; Posttraumatic stress disorder; Psychopathologie; Psychopathology; Soldiers; Epidemiologie; Etat de stress post-traumatique  
  Abstract BACKGROUND: The psychotraumatic disorders are often difficult to diagnose because the specific symptoms of posttraumatic stress disorder (revival, hyperarousal, avoidance) are rarely a direct demand for health care: for reasons determined by the psychopathological structure of trauma, its symptomatology and course, the psychotraumatised subjects seek a care system for nonspecific psychological or somatoform symptoms: depressive episode, cognitive disorders, other anxiety disorders, histrionic and obsessive symptoms, changes in personality, pain disorders and somatization. Somatic pain may also result from a war injury and psychosomatic complications, addictive or consequences of risk behaviours during the evolution of posttraumatic stress disorder. OBJECTIVES: To establish a correlation between the PCLS and the evaluation of the healthcare consumption in a military population. METHODS: We conducted a multicenter epidemiological study analyzing the PCLS and a questionnaire assessing health care consumption. The PCLS has been studied in various forms: quantitative (17 to 85), in qualitative classes (<33, 33 to 43 and >/=44), and in five sub-dimensions (flashbacks, avoidance, dissociation, depression and hyperactivity). The sub-dimension revival was then studied item by item. The criteria used care consumption over the last twelve months is the numbers of days of sick leave, days of unavailability (of certain jobs or military activities) and consultations. RESULTS: Our population of 340 subjects cannot be considered representative of the French military population even if only a few characteristics differ. Sixteen of 340 subjects show a positive PCLS is 4.70% of our sample. PCLS average of 23 (+/-9.4) with a median of 19 objectifying much of PCLS have almost zero score. Validating our main hypothesis, we found a statistically significant relationship between elements of the PCLS and variables care consumption: this link exists mainly between the score, classes and sub-dimensions of the PCLS in one hand and number of days of sick leave and unavailability on the other hand. DISCUSSION: Towards a strategy for tracking psychotraumatic disorders, could be developed a score of health care consumption which would include the number of days of sick leave and unavailability, the number and quality of medical consultations, the number and quality of drug and laboratory requirements, the number of hospitalisations. To the identification of posttraumatic stress disorder, the PCLS score as well as the consumer healthcare score are valuable tools but do not replace the subjectivity of the clinical relationship: return to this shared subjectivity with the practitioner remains a diagnostic dimension, but also therapeutic, fundamental.  
  Address HIA Percy, 101, avenue Henri-Barbusse, BP 406, 92140 Clamart, France. Electronic address: yann.auxemery@hotmail.fr  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language French Summary Language Original Title Etat de stress post-traumatique et consommation de soins sur l'annee ecoulee : etude menee aupres de 340 militaires francais de cinq unites combattantes de l'armee de terre  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0013-7006 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26049671 Approved no  
  Call Number UU @ jana.mullerova @ Serial 42181  
Permanent link to this record
 

 
Author Hunter, S.M.; Anglesio, M.S.; Ryland, G.L.; Sharma, R.; Chiew, Y.E.; Rowley, S.M.; Doyle, M.A.; Li, J.; Gilks, C.B.; Moss, P.; Allan, P.E.; Stephens, A.N.; Huntsman, D.G.; deFazio, A.; Bowtell, D.D.; Australian, O.C.S.G.; Gorringe, K.L.; Campbell, I.G. url  openurl
  Title Molecular profiling of low grade serous ovarian tumours identifies novel candidate driver genes Type Journal Article
  Year 2015 Publication Abbreviated Journal Oncotarget  
  Volume 6 Issue 35 Pages 37663-37677  
  Keywords  
  Abstract Low grade serous ovarian tumours are a rare and under-characterised histological subtype of epithelial ovarian tumours, with little known of the molecular drivers and facilitators of tumorigenesis beyond classic oncogenic RAS/RAF mutations. With a move towards targeted therapies due to the chemoresistant nature of this subtype, it is pertinent to more fully characterise the genetic events driving this tumour type, some of which may influence response to therapy and/or development of drug resistance. We performed genome-wide high-resolution genomic copy number analysis (Affymetrix SNP6.0) and mutation hotspot screening (KRAS, BRAF, NRAS, HRAS, ERBB2 and TP53) to compare a large cohort of ovarian serous borderline tumours (SBTs, n = 57) with low grade serous carcinomas (LGSCs, n = 19). Whole exome sequencing was performed for 13 SBTs, nine LGSCs and one mixed low/high grade carcinoma. Copy number aberrations were detected in 61% (35/57) of SBTs, compared to 100% (19/19) of LGSCs. Oncogenic RAS/RAF/ERBB2 mutations were detected in 82.5% (47/57) of SBTs compared to 63% (12/19) of LGSCs, with NRAS mutations detected only in LGSC. Some copy number aberrations appeared to be enriched in LGSC, most significantly loss of 9p and homozygous deletions of the CDKN2A/2B locus. Exome sequencing identified BRAF, KRAS, NRAS, USP9X and EIF1AX as the most frequently mutated genes. We have identified markers of progression from borderline to LGSC and novel drivers of LGSC. USP9X and EIF1AX have both been linked to regulation of mTOR, suggesting that mTOR inhibitors may be a key companion treatment for targeted therapy trials of MEK and RAF inhibitors.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number UofT @ ankit.sinha @ Serial 44942  
Permanent link to this record
 

 
Author Ignatchenko, V.; Ignatchenko, A.; Sinha, A.; Boutros, P.C.; Kislinger, T. url  openurl
  Title VennDIS: a JavaFX-based Venn and Euler diagram software to generate publication quality figures Type Journal Article
  Year 2015 Publication Abbreviated Journal Proteomics  
  Volume 15 Issue 7 Pages 1239-1244  
  Keywords  
  Abstract Venn diagrams are graphical representations of the relationships among multiple sets of objects and are often used to illustrate similarities and differences among genomic and proteomic datasets. All currently existing tools for producing Venn diagrams evince one of two traits; they require expertise in specific statistical software packages (such as R), or lack the flexibility required to produce publication-quality figures. We describe a simple tool that addresses both shortcomings, Venn Diagram Interactive Software (VennDIS), a JavaFX-based solution for producing highly customizable, publication-quality Venn, and Euler diagrams of up to five sets. The strengths of VennDIS are its simple graphical user interface and its large array of customization options, including the ability to modify attributes such as font, style and position of the labels, background color, size of the circle/ellipse, and outline color. It is platform independent and provides real-time visualization of figure modifications. The created figures can be saved as XML files for future modification or exported as high-resolution images for direct use in publications.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number UofT @ ankit.sinha @ Serial 45271  
Permanent link to this record
Select All    Deselect All
 |   | 
Details
   print

Save Citations:
Export Records: