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Author Lanius, R.A. url  openurl
  Title Trauma-related dissociation and altered states of consciousness: a call for clinical, treatment, and neuroscience research Type Journal Article
  Year 2015 Publication European Journal of Psychotraumatology Abbreviated Journal Eur J Psychotraumatol  
  Volume 6 Issue Pages (down) 27905  
  Keywords Dissociation; anterior cingulate; complex PTSD; consciousness; dissociative subtype; emotion; insula; interoceptive awareness  
  Abstract The primary aim of this commentary is to describe trauma-related dissociation and altered states of consciousness in the context of a four-dimensional model that has recently been proposed (Frewen & Lanius, 2015). This model categorizes symptoms of trauma-related psychopathology into (1) those that occur within normal waking consciousness and (2) those that are dissociative and are associated with trauma-related altered states of consciousness (TRASC) along four dimensions: (1) time; (2) thought; (3) body; and (4) emotion. Clinical applications and future research directions relevant to each dimension are discussed. Conceptualizing TRASC across the dimensions of time, thought, body, and emotion has transdiagnostic implications for trauma-related disorders described in both the Diagnostic Statistical Manual and the International Classifications of Diseases. The four-dimensional model provides a framework, guided by existing models of dissociation, for future research examining the phenomenological, neurobiological, and physiological underpinnings of trauma-related dissociation.  
  Address Western University, Lawson Health Research Institute, London, ON, Canada; Ruth.Lanius@lhsc.on.ca  
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  Series Volume Series Issue Edition  
  ISSN 2000-8066 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25994026 Approved no  
  Call Number UU @ jana.mullerova @ Serial 42183  
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Author Frewen, P.A.; Brown, M.F.D.; Steuwe, C.; Lanius, R.A. url  openurl
  Title Latent profile analysis and principal axis factoring of the DSM-5 dissociative subtype Type Journal Article
  Year 2015 Publication European Journal of Psychotraumatology Abbreviated Journal Eur J Psychotraumatol  
  Volume 6 Issue Pages (down) 26406  
  Keywords Posttraumatic stress disorder; dissociation; dissociative subtype; psychological trauma; trauma-related altered states of consciousness  
  Abstract OBJECTIVE: A dissociative subtype has been recognized based on the presence of experiences of depersonalization and derealization in relation to DSM-IV posttraumatic stress disorder (PTSD). However, the dissociative subtype has not been assessed in a community sample in relation to the revised DSM-5 PTSD criteria. Moreover, the 20-item PTSD Checklist for DSM-5 (PCL-5) currently does not assess depersonalization and derealization. METHOD: We therefore evaluated two items for assessing depersonalization and derealization in 557 participants recruited online who endorsed PTSD symptoms of at least moderate severity on the PCL-5. RESULTS: A five-class solution identified two PTSD classes who endorsed dissociative experiences associated with either 1) severe or 2) moderate PTSD symptom severity (D-PTSD classes). Those in the severe dissociative class were particularly likely to endorse histories of childhood physical and sexual abuse. A principal axis factor analysis of the symptom list identified six latent variables: 1) Reexperiencing, 2) Emotional Numbing/Anhedonia, 3) Dissociation, 4) Negative Alterations in Cognition & Mood, 5) Avoidance, and 6) Hyperarousal. CONCLUSIONS: The present results further support the presence of a dissociative subtype within the DSM-5 criteria for PTSD.  
  Address Graduate Program in Neuroscience, Western University, London, Ontario, Canada  
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  Language English Summary Language Original Title  
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  Series Volume Series Issue Edition  
  ISSN 2000-8066 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25854673 Approved no  
  Call Number UU @ jana.mullerova @ Serial 42188  
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Author Schalinski, I.; Schauer, M.; Elbert, T. url  openurl
  Title The shutdown dissociation scale (shut-d) Type Journal Article
  Year 2015 Publication European Journal of Psychotraumatology Abbreviated Journal Eur J Psychotraumatol  
  Volume 6 Issue Pages (down) 25652  
  Keywords Ptsd; Shutdown dissociation; assessment; multiple trauma; subtype  
  Abstract The evolutionary model of the defense cascade by Schauer and Elbert (2010) provides a theoretical frame for a short interview to assess problems underlying and leading to the dissociative subtype of posttraumatic stress disorder. Based on known characteristics of the defense stages “fright,” “flag,” and “faint,” we designed a structured interview to assess the vulnerability for the respective types of dissociation. Most of the scales that assess dissociative phenomena are designed as self-report questionnaires. Their items are usually selected based on more heuristic considerations rather than a theoretical model and thus include anything from minor dissociative experiences to major pathological dissociation. The shutdown dissociation scale (Shut-D) was applied in several studies in patients with a history of multiple traumatic events and different disorders that have been shown previously to be prone to symptoms of dissociation. The goal of the present investigation was to obtain psychometric characteristics of the Shut-D (including factor structure, internal consistency, retest reliability, predictive, convergent and criterion-related concurrent validity). A total population of 225 patients and 68 healthy controls were accessed. Shut-D appears to have sufficient internal reliability, excellent retest reliability, high convergent validity, and satisfactory predictive validity, while the summed score of the scale reliably separates patients with exposure to trauma (in different diagnostic groups) from healthy controls. The Shut-D is a brief structured interview for assessing the vulnerability to dissociate as a consequence of exposure to traumatic stressors. The scale demonstrates high-quality psychometric properties and may be useful for researchers and clinicians in assessing shutdown dissociation as well as in predicting the risk of dissociative responding.  
  Address Department of Psychology, University of Konstanz, Konstanz, Germany  
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  ISSN 2000-8066 ISBN Medium  
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  Notes PMID:25976478 Approved no  
  Call Number UU @ jana.mullerova @ Serial 42184  
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Author Laurenti, M.; Verna, A.; Chiolerio, A. url  openurl
  Title Evidence of Negative Capacitance in Piezoelectric ZnO Thin Films Sputtered on Interdigital Electrodes Type Journal Article
  Year 2015 Publication Abbreviated Journal ACS Applied Materials and Interfaces  
  Volume 7 Issue 44 Pages (down) 24470-24479  
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  Notes Cited By :6; Export Date: 2 November 2016 Approved no  
  Call Number IIT-CSF @ alessandro.chiolerio @ Serial 42775  
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Author Boulfelfel, S.E.; Ravikovitch, P.I.; Sholl, D.S. doi  openurl
  Title Modeling Diffusion of Linear Hydrocarbons in Silica Zeolite LTA Using Transition Path Sampling Type Journal Article
  Year 2015 Publication Abbreviated Journal The Journal of Physical Chemistry C  
  Volume 119 Issue 27 Pages (down) 15643-15653  
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  Abstract The diffusivities of linear hydrocarbons (CH4, C2H6, C2H4, C3H8, C3H6, and C4H10) in pure silica zeolite LTA (ITQ-29) are computed at 300 K and infinite dilution. To overcome the time scale problem arising from the slow diffusion process at room temperature, we used transition path sampling (TPS). The influence of framework flexibility on diffusion is investigated by combining TPS simulations with fully flexible molecular dynamics performed in the NpT ensemble. The ensemble of the collected reactive trajectories was used to characterize sets of transition states, and the corresponding configurations were analyzed to construct window size distributions during the molecular hopping events. The diffusion process is affected by framework flexibility, and the influence of framework flexibility on diffusion of propane and butane is much larger than for methane and ethane. The diffusivities of linear hydrocarbons (CH4, C2H6, C2H4, C3H8, C3H6, and C4H10) in pure silica zeolite LTA (ITQ-29) are computed at 300 K and infinite dilution. To overcome the time scale problem arising from the slow diffusion process at room temperature, we used transition path sampling (TPS). The influence of framework flexibility on diffusion is investigated by combining TPS simulations with fully flexible molecular dynamics performed in the NpT ensemble. The ensemble of the collected reactive trajectories was used to characterize sets of transition states, and the corresponding configurations were analyzed to construct window size distributions during the molecular hopping events. The diffusion process is affected by framework flexibility, and the influence of framework flexibility on diffusion of propane and butane is much larger than for methane and ethane.  
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  ISSN 1932-7447 ISBN Medium  
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  Notes Times cited: 17 Approved no  
  Call Number AG @ matthewjvarga @ Serial 46121  
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Author Lee, C.‐U.; Hahne, G.; Hanske, J.; Bange, T.; Bier, D.; Rademacher, C.; Hennig, S.; Grossmann, T.N. openurl 
  Title Redox Modulation of PTEN Phosphatase Activity by Hydrogen Peroxide and Bisperoxidovanadium Complexes Type Journal Article
  Year 2015 Publication Abbreviated Journal Angewandte Chemie International Edition  
  Volume 54 Issue 46 Pages (down) 13796-13800  
  Keywords pdb,gene:PTEN,pdb:5BUG,pdb:5BZX,pdb:5BZZ  
  Abstract PTEN is a dual-specificity protein tyrosine phosphatase. As one of the central tumor suppressors, a thorough regulation of its activity is essential for proper cellular homeostasis. The precise implications of PTEN inhibition by reactive oxygen species (e.g. H2O2) and the subsequent structural consequences remain elusive. To study the effects of PTEN inhibition, bisperoxidovanadium (bpV) complexes serve as important tools with the potential for the treatment of nerve injury or cardiac ischemia. However, their mode of action is unknown, hampering further optimization and preventing therapeutic applications. Based on protein crystallography, mass spectrometry, and NMR spectroscopy, we elucidate the molecular basis of PTEN inhibition by H2O2 and bpV complexes. We show that both molecules inhibit PTEN via oxidative mechanisms resulting in the formation of the same intramolecular disulfide, therefore enabling the reactivation of PTEN under reductive conditions.  
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  ISSN 1521-3773 ISBN Medium  
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  Notes Approved no  
  Call Number AG @ matthewjvarga @ Serial 47153  
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Author Astanina, K.; Koch, M.; Jüngst, C.; Zumbusch, A.; Kiemer, A.K. url  openurl
  Title Lipid droplets as a novel cargo of tunnelling nanotubes in endothelial cells Type Journal Article
  Year 2015 Publication Abbreviated Journal Sci Rep  
  Volume 5 Issue Pages (down) 11453  
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  Abstract Intercellular communication is a fundamental process in the development and functioning of multicellular organisms. Recently, an essentially new type of intercellular communication, based on thin membrane channels between cells, has been reported. These structures, termed intercellular or tunnelling nanotubes (TNTs), permit the direct exchange of various components or signals (e.g., ions, proteins, or organelles) between non-adjacent cells at distances over 100 μm. Our studies revealed the presence of tunnelling nanotubes in microvascular endothelial cells (HMEC-1). The TNTs were studied with live cell imaging, environmental scanning electron microscopy (ESEM), and coherent anti-Stokes Raman scattering spectroscopy (CARS). Tunneling nanotubes showed marked persistence: the TNTs could connect cells over long distances (up to 150 μm) for several hours. Several cellular organelles were present in TNTs, such as lysosomes and mitochondria. Moreover, we could identify lipid droplets as a novel type of cargo in the TNTs. Under angiogenic conditions (VEGF treatment) the number of lipid droplets increased significantly. Arachidonic acid application not only increased the number of lipid droplets but also tripled the extent of TNT formation. Taken together, our results provide the first demonstration of lipid droplets as a cargo of TNTs and thereby open a new field in intercellular communication research.  
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  ISSN 2045-2322 ISBN Medium  
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  Notes Approved no  
  Call Number UofT @ mathieu.lemaire @ Serial 45959  
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Author Suarez, J.; Schramm, V.L. doi  openurl
  Title Isotope-specific and amino acid-specific heavy atom substitutions alter barrier crossing in human purine nucleoside phosphorylase Type Journal Article
  Year 2015 Publication Abbreviated Journal Proceedings of the National Academy of Sciences  
  Volume 112 Issue 36 Pages (down) 11247-11251  
  Keywords Born--Oppenheimer enzymes femtosecond dynamics heavy enzymes pre--steady-state chemistry transition state coupling  
  Abstract <jats:p>Computational chemistry predicts that atomic motions on the femtosecond timescale are coupled to transition-state formation (barrier-crossing) in human purine nucleoside phosphorylase (PNP). The prediction is experimentally supported by slowed catalytic site chemistry in isotopically labeled PNP (<jats:sup>13</jats:sup>C, <jats:sup>15</jats:sup>N, and <jats:sup>2</jats:sup>H). However, other explanations are possible, including altered volume or bond polarization from carbon-deuterium bonds or propagation of the femtosecond bond motions into slower (nanoseconds to milliseconds) motions of the larger protein architecture to alter catalytic site chemistry. We address these possibilities by analysis of chemistry rates in isotope-specific labeled PNPs. Catalytic site chemistry was slowed for both [<jats:sup>2</jats:sup>H]PNP and [<jats:sup>13</jats:sup>C, <jats:sup>15</jats:sup>N]PNP in proportion to their altered protein masses. Secondary effects emanating from carbon–deuterium bond properties can therefore be eliminated. Heavy-enzyme mass effects were probed for local or global contributions to catalytic site chemistry by generating [<jats:sup>15</jats:sup>N, <jats:sup>2</jats:sup>H]His<jats:sub>8</jats:sub>-PNP. Of the eight His per subunit, three participate in contacts to the bound reactants and five are remote from the catalytic sites. [<jats:sup>15</jats:sup>N, <jats:sup>2</jats:sup>H]His<jats:sub>8</jats:sub>-PNP had reduced catalytic site chemistry larger than proportional to the enzymatic mass difference. Altered barrier crossing when only His are heavy supports local catalytic site femtosecond perturbations coupled to transition-state formation. Isotope-specific and amino acid specific labels extend the use of heavy enzyme methods to distinguish global from local isotope effects.</jats:p  
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  Notes Times cited: 18 Approved no  
  Call Number AG @ matthewjvarga @ Serial 46225  
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Author Kadiyska, T.; Nossikoff, A. url  openurl
  Title Stool DNA methylation assays in colorectal cancer screening Type Journal Article
  Year 2015 Publication Abbreviated Journal World J Gastroenterol  
  Volume 21 Issue 35 Pages (down) 10057-10061  
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  Abstract Colorectal cancer (CRC) is fourth most common cancer in men and third in women worldwide. Developing a diagnostic panel of sensitive and specific biomarkers for the early detection of CRC is recognised as to be crucial for early initial diagnosis, which in turn leads to better long term survival. Most of the research on novel potential CRC biomarkers in the last 2 decades has been focussed on stool DNA analysis. In this paper, we describe the recent advances in non-invasive CRC screening and more specifically in molecular assays for aberrantly methylated BMP3 and NDRG4 promoter regions. In several research papers these markers showed superior rates for sensitivity and specificity in comparison to previously described assays. These tests detected the majority of adenomas ≥ 1 cm in size and the detection rates progressively increased with larger adenomas. The methylation status of the BMP3 and NDRG4 promoters demonstrated effective detection of neoplasms at all sites throughout the colon and was not affected by common clinical variables. Recently, a multitarget stool DNA test consisting of molecular assays for aberrantly methylated BMP3 and NDRG4 promoter regions, mutant KRAS and immunochemical assay for human haemoglobin has been made commercially available and is currently reimbursed in the United States. Although this is the most sensitive non-invasive CRC screening test, there is the need for further research in several areas – establishment of the best timeframe for repeated DNA stool testing; validation of the results in populations outside of North America; usefulness for surveillance and prognosis of patients; cost-effectiveness of DNA stool testing in real-life populations.  
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  Call Number UofT @ ankit.sinha @ Serial 45144  
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Author Sowers, J.L.; Mirfattah, B.; Xu, P.; Tang, H.; Park, I.Y.; Walker, C.; Wu, P.; Laezza, F.; Sowers, L.C.; Zhang, K. url  openurl
  Title Quantification of histone modifications by parallel-reaction monitoring: a method validation Type Journal Article
  Year 2015 Publication Abbreviated Journal Anal Chem  
  Volume 87 Issue 19 Pages (down) 10006-10014  
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  Abstract Abnormal epigenetic reprogramming is one of the major causes leading to irregular gene expression and regulatory pathway perturbations, in the cells, resulting in unhealthy cell development or diseases. Accurate measurements of these changes of epigenetic modifications, especially the complex histone modifications, are very important, and the methods for these measurements are not trivial. By following our previous introduction of PRM to targeting histone modifications (Tang, H.; Fang, H.; Yin, E.; Brasier, A. R.; Sowers, L. C.; Zhang, K. Multiplexed parallel reaction monitoring targeting histone modifications on the QExactive mass spectrometer. Anal. Chem. 2014, 86 (11), 5526-34), herein we validated this method by varying the protein/trypsin ratios via serial dilutions. Our data demonstrated that PRM with SILAC histones as the internal standards allowed reproducible measurements of histone H3/H4 acetylation and methylation in the samples whose histone contents differ at least one-order of magnitude. The method was further validated by histones isolated from histone H3 K36 trimethyltransferase SETD2 knockout mouse embryonic fibroblasts (MEF) cells. Furthermore, histone acetylation and methylation in human neural stem cells (hNSC) treated with ascorbic acid phosphate (AAP) were measured by this method, revealing that H3 K36 trimethylation was significantly down-regulated by 6 days of treatment with vitamin C.  
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  Notes Approved no  
  Call Number UofT @ ankit.sinha @ Serial 45227  
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