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Author Rutten, M.J.; Sonke, G.S.; Westermann, A.M.; van Driel, W.J.; Trum, J.W.; Kenter, G.G.; Buist, M.R.
Title Prognostic Value of Residual Disease after Interval Debulking Surgery for FIGO Stage IIIC and IV Epithelial Ovarian Cancer Type Journal Article
Year 2015 Publication Abbreviated Journal Obstet Gynecol Int
Volume 2015 Issue Pages (down) 464123
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Abstract Although complete debulking surgery for epithelial ovarian cancer (EOC) is more often achieved with interval debulking surgery (IDS) following neoadjuvant chemotherapy (NACT), randomized evidence shows no long-term survival benefit compared to complete primary debulking surgery (PDS). We performed an observational cohort study of patients treated with debulking surgery for advanced EOC to evaluate the prognostic value of residual disease after debulking surgery. All patients treated between 1998 and 2010 in three Dutch referral gynaecological oncology centres were included. The prognostic value of residual disease after surgery for disease specific survival was assessed using Cox-regression analyses. In total, 462 patients underwent NACT-IDS and 227 PDS. Macroscopic residual disease after debulking surgery was an independent prognostic factor for survival in both treatment modalities. Yet, residual tumour less than one centimetre at IDS was associated with a survival benefit of five months compared to leaving residual tumour more than one centimetre, whereas this benefit was not seen after PDS. Leaving residual tumour at IDS is a poor prognostic sign as it is after PDS. The specific prognostic value of residual tumour seems to depend on the clinical setting, as minimal instead of gross residual tumour is associated with improved survival after IDS, but not after PDS.
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Call Number UofT @ ankit.sinha @ Serial 45336
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Author Kampan, N.C.; Madondo, M.T.; McNally, O.M.; Quinn, M.; Plebanski, M.
Title Paclitaxel and Its Evolving Role in the Management of Ovarian Cancer Type Journal Article
Year 2015 Publication Abbreviated Journal Biomed Res Int
Volume 2015 Issue Pages (down) 413076
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Abstract Paclitaxel, a class of taxane with microtubule stabilising ability, has remained with platinum based therapy, the standard care for primary ovarian cancer management. A deeper understanding of the immunological basis and other potential mechanisms of action together with new dosing schedules and/or routes of administration may potentiate its clinical benefit. Newer forms of taxanes, with better safety profiles and higher intratumoural cytotoxicity, have yet to demonstrate clinical superiority over the parent compound.
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Call Number UofT @ ankit.sinha @ Serial 45056
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Author Lagendijk, D.D.G.; Thaker, M.; de Boer, W.F.; Page, B.R.; Prins, H.H.T.; Slotow, R.
Title Change in Mesoherbivore Browsing Is Mediated by Elephant and Hillslope Position Type Journal Article
Year 2015 Publication Abbreviated Journal PLoS ONE
Volume 10 Issue 6 Pages (down) e0128340
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Abstract Elephant are considered major drivers of ecosystems, but their effects within small-scale landscape features and on other herbivores still remain unclear. Elephant impact on vegetation has been widely studied in areas where elephant have been present for many years. We therefore examined the combined effect of short-term elephant presence (< 4 years) and hillslope position on tree species assemblages, resource availability, browsing intensity and soil properties. Short-term elephant presence did not affect woody species assemblages, but did affect height distribution, with greater sapling densities in elephant access areas. Overall tree and stem densities were also not affected by elephant. By contrast, slope position affected woody species assemblages, but not height distributions and densities. Variation in species assemblages was statistically best explained by levels of total cations, Zinc, sand and clay. Although elephant and mesoherbivore browsing intensities were unaffected by slope position, we found lower mesoherbivore browsing intensity on crests with high elephant browsing intensity. Thus, elephant appear to indirectly facilitate the survival of saplings, via the displacement of mesoherbivores, providing a window of opportunity for saplings to grow into taller trees. In the short-term, effects of elephant can be minor and in the opposite direction of expectation. In addition, such behavioural displacement promotes recruitment of saplings into larger height classes. The interaction between slope position and elephant effect found here is in contrast with other studies, and illustrates the importance of examining ecosystem complexity as a function of variation in species presence and topography. The absence of a direct effect of elephant on vegetation, but the presence of an effect on mesoherbivore browsing, is relevant for conservation areas especially where both herbivore groups are actively managed.
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Call Number CES @ dilipnaidu.gt @ Serial 43051
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Author Naniwadekar, R.; Shukla, U.; Isvaran, K.; Datta, A.
Title Reduced Hornbill Abundance Associated with Low Seed Arrival and Altered Recruitment in a Hunted and Logged Tropical Forest Type Journal Article
Year 2015 Publication Abbreviated Journal PLoS ONE
Volume 10 Issue 3 Pages (down) e0120062
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Abstract Logging and hunting are two key direct threats to the survival of wildlife in the tropics, and also disrupt important ecosystem processes. We investigated the impacts of these two factors on the different stages of the seed dispersal cycle, including abundance of plants and their dispersers and dispersal of seeds and recruitment, in a tropical forest in north-east India. We focused on hornbills, which are important seed dispersers in these forests, and their food tree species. We compared abundances of hornbill food tree species in a site with high logging and hunting pressures (heavily disturbed) with a site that had no logging and relatively low levels of hunting (less disturbed) to understand logging impacts on hornbill food tree abundance. We compared hornbill abundances across these two sites. We, then, compared the scatter-dispersed seed arrival of five large-seeded tree species and the recruitment of four of those species. Abundances of hornbill food trees that are preferentially targeted by logging were two times higher in the less disturbed site as compared to the heavily disturbed site while that of hornbills was 22 times higher. The arrival of scatter-dispersed seeds was seven times higher in the less disturbed site. Abundances of recruits of two tree species were significantly higher in the less disturbed site. For another species, abundances of younger recruits were significantly lower while that of older recruits were higher in the heavily disturbed site. Our findings suggest that logging reduces food plant abundance for an important frugivore-seed disperser group, while hunting diminishes disperser abundances, with an associated reduction in seed arrival and altered recruitment of animal-dispersed tree species in the disturbed site. Based on our results, we present a conceptual model depicting the relationships and pathways between vertebrate-dispersed trees, their dispersers, and the impacts of hunting and logging on these pathways.
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Call Number CES @ dilipnaidu.gt @ Serial 43037
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Author Roppolo, I.; Chiappone, A.; Boggione, L.; Castellino, M.; Bejtka, K.; Pirri, C.F.; Sangermano, M.; Chiolerio, A.
Title Self-standing polymer-functionalized reduced graphene oxide papers obtained via a UV-process Type Journal Article
Year 2015 Publication Abbreviated Journal RSC Advances
Volume 5 Issue 116 Pages (down) 95805-95812
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Notes Cited By :2; Export Date: 2 November 2016 Approved no
Call Number IIT-CSF @ alessandro.chiolerio @ Serial 42776
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Author Hunter, S.M.; Anglesio, M.S.; Ryland, G.L.; Sharma, R.; Chiew, Y.E.; Rowley, S.M.; Doyle, M.A.; Li, J.; Gilks, C.B.; Moss, P.; Allan, P.E.; Stephens, A.N.; Huntsman, D.G.; deFazio, A.; Bowtell, D.D.; Australian, O.C.S.G.; Gorringe, K.L.; Campbell, I.G.
Title Molecular profiling of low grade serous ovarian tumours identifies novel candidate driver genes Type Journal Article
Year 2015 Publication Abbreviated Journal Oncotarget
Volume 6 Issue 35 Pages (down) 37663-37677
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Abstract Low grade serous ovarian tumours are a rare and under-characterised histological subtype of epithelial ovarian tumours, with little known of the molecular drivers and facilitators of tumorigenesis beyond classic oncogenic RAS/RAF mutations. With a move towards targeted therapies due to the chemoresistant nature of this subtype, it is pertinent to more fully characterise the genetic events driving this tumour type, some of which may influence response to therapy and/or development of drug resistance. We performed genome-wide high-resolution genomic copy number analysis (Affymetrix SNP6.0) and mutation hotspot screening (KRAS, BRAF, NRAS, HRAS, ERBB2 and TP53) to compare a large cohort of ovarian serous borderline tumours (SBTs, n = 57) with low grade serous carcinomas (LGSCs, n = 19). Whole exome sequencing was performed for 13 SBTs, nine LGSCs and one mixed low/high grade carcinoma. Copy number aberrations were detected in 61% (35/57) of SBTs, compared to 100% (19/19) of LGSCs. Oncogenic RAS/RAF/ERBB2 mutations were detected in 82.5% (47/57) of SBTs compared to 63% (12/19) of LGSCs, with NRAS mutations detected only in LGSC. Some copy number aberrations appeared to be enriched in LGSC, most significantly loss of 9p and homozygous deletions of the CDKN2A/2B locus. Exome sequencing identified BRAF, KRAS, NRAS, USP9X and EIF1AX as the most frequently mutated genes. We have identified markers of progression from borderline to LGSC and novel drivers of LGSC. USP9X and EIF1AX have both been linked to regulation of mTOR, suggesting that mTOR inhibitors may be a key companion treatment for targeted therapy trials of MEK and RAF inhibitors.
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Call Number UofT @ ankit.sinha @ Serial 44942
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Author Øverbye, A.; Skotland, T.; Koehler, C.J.; Thiede, B.; Seierstad, T.; Berge, V.; Sandvig, K.; Llorente, A.
Title Identification of prostate cancer biomarkers in urinary exosomes Type Journal Article
Year 2015 Publication Abbreviated Journal Oncotarget
Volume 6 Issue 30 Pages (down) 30357-30376
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Abstract Exosomes have recently appeared as a novel source of non-invasive cancer biomarkers since tumour-specific molecules can be found in exosomes isolated from biological fluids. We have here investigated the proteome of urinary exosomes by using mass spectrometry to identify proteins differentially expressed in prostate cancer patients compared to healthy male controls. In total, 15 control and 16 prostate cancer samples of urinary exosomes were analyzed. Importantly, 246 proteins were differentially expressed in the two groups. The majority of these proteins (221) were up-regulated in exosomes from prostate cancer patients. These proteins were analyzed according to specific criteria to create a focus list that contained 37 proteins. At 100% specificity, 17 of these proteins displayed individual sensitivities above 60%. Even though several of these proteins showed high sensitivity and specificity for prostate cancer as individual biomarkers, combining them in a multi-panel test has the potential for full differentiation of prostate cancer from non-disease controls. The highest sensitivity, 94%, was observed for transmembrane protein 256 (TM256; chromosome 17 open reading frame 61). LAMTOR proteins were also distinctly enriched with very high specificity for patient samples. TM256 and LAMTOR1 could be used to augment the sensitivity to 100%. Other prominent proteins were V-type proton ATPase 16 kDa proteolipid subunit (VATL), adipogenesis regulatory factor (ADIRF), and several Rab-class members and proteasomal proteins. In conclusion, this study clearly shows the potential of using urinary exosomes in the diagnosis and clinical management of prostate cancer.
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Call Number UofT @ ankit.sinha @ Serial 45334
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Author Hansen, M.; Hyland, P.; Armour, C.; Shevlin, M.; Elklit, A.
Title Less is more? Assessing the validity of the ICD-11 model of PTSD across multiple trauma samples Type Journal Article
Year 2015 Publication European Journal of Psychotraumatology Abbreviated Journal Eur J Psychotraumatol
Volume 6 Issue Pages (down) 28766
Keywords Cfa; Dsm-5; Icd-11; Ptsd; latent structure
Abstract BACKGROUND: In the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), the symptom profile of posttraumatic stress disorder (PTSD) was expanded to include 20 symptoms. An alternative model of PTSD is outlined in the proposed 11th edition of the International Classification of Diseases (ICD-11) that includes just six symptoms. OBJECTIVES AND METHOD: The objectives of the current study are: 1) to independently investigate the fit of the ICD-11 model of PTSD, and three DSM-5-based models of PTSD, across seven different trauma samples (N=3,746) using confirmatory factor analysis; 2) to assess the concurrent validity of the ICD-11 model of PTSD; and 3) to determine if there are significant differences in diagnostic rates between the ICD-11 guidelines and the DSM-5 criteria. RESULTS: The ICD-11 model of PTSD was found to provide excellent model fit in six of the seven trauma samples, and tests of factorial invariance showed that the model performs equally well for males and females. DSM-5 models provided poor fit of the data. Concurrent validity was established as the ICD-11 PTSD factors were all moderately to strongly correlated with scores of depression, anxiety, dissociation, and aggression. Levels of association were similar for ICD-11 and DSM-5 suggesting that explanatory power is not affected due to the limited number of items included in the ICD-11 model. Diagnostic rates were significantly lower according to ICD-11 guidelines compared to the DSM-5 criteria. CONCLUSIONS: The proposed factor structure of the ICD-11 model of PTSD appears valid across multiple trauma types, possesses good concurrent validity, and is more stringent in terms of diagnosis compared to the DSM-5 criteria.
Address Department of Psychology, National Centre for Psychotraumatology, University of Southern Denmark, Odense M, Denmark
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ISSN 2000-8066 ISBN Medium
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Notes PMID:26450830 Approved no
Call Number UU @ jana.mullerova @ Serial 42172
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Author Lanius, R.A.
Title Trauma-related dissociation and altered states of consciousness: a call for clinical, treatment, and neuroscience research Type Journal Article
Year 2015 Publication European Journal of Psychotraumatology Abbreviated Journal Eur J Psychotraumatol
Volume 6 Issue Pages (down) 27905
Keywords Dissociation; anterior cingulate; complex PTSD; consciousness; dissociative subtype; emotion; insula; interoceptive awareness
Abstract The primary aim of this commentary is to describe trauma-related dissociation and altered states of consciousness in the context of a four-dimensional model that has recently been proposed (Frewen & Lanius, 2015). This model categorizes symptoms of trauma-related psychopathology into (1) those that occur within normal waking consciousness and (2) those that are dissociative and are associated with trauma-related altered states of consciousness (TRASC) along four dimensions: (1) time; (2) thought; (3) body; and (4) emotion. Clinical applications and future research directions relevant to each dimension are discussed. Conceptualizing TRASC across the dimensions of time, thought, body, and emotion has transdiagnostic implications for trauma-related disorders described in both the Diagnostic Statistical Manual and the International Classifications of Diseases. The four-dimensional model provides a framework, guided by existing models of dissociation, for future research examining the phenomenological, neurobiological, and physiological underpinnings of trauma-related dissociation.
Address Western University, Lawson Health Research Institute, London, ON, Canada; Ruth.Lanius@lhsc.on.ca
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Notes PMID:25994026 Approved no
Call Number UU @ jana.mullerova @ Serial 42183
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Author Frewen, P.A.; Brown, M.F.D.; Steuwe, C.; Lanius, R.A.
Title Latent profile analysis and principal axis factoring of the DSM-5 dissociative subtype Type Journal Article
Year 2015 Publication European Journal of Psychotraumatology Abbreviated Journal Eur J Psychotraumatol
Volume 6 Issue Pages (down) 26406
Keywords Posttraumatic stress disorder; dissociation; dissociative subtype; psychological trauma; trauma-related altered states of consciousness
Abstract OBJECTIVE: A dissociative subtype has been recognized based on the presence of experiences of depersonalization and derealization in relation to DSM-IV posttraumatic stress disorder (PTSD). However, the dissociative subtype has not been assessed in a community sample in relation to the revised DSM-5 PTSD criteria. Moreover, the 20-item PTSD Checklist for DSM-5 (PCL-5) currently does not assess depersonalization and derealization. METHOD: We therefore evaluated two items for assessing depersonalization and derealization in 557 participants recruited online who endorsed PTSD symptoms of at least moderate severity on the PCL-5. RESULTS: A five-class solution identified two PTSD classes who endorsed dissociative experiences associated with either 1) severe or 2) moderate PTSD symptom severity (D-PTSD classes). Those in the severe dissociative class were particularly likely to endorse histories of childhood physical and sexual abuse. A principal axis factor analysis of the symptom list identified six latent variables: 1) Reexperiencing, 2) Emotional Numbing/Anhedonia, 3) Dissociation, 4) Negative Alterations in Cognition & Mood, 5) Avoidance, and 6) Hyperarousal. CONCLUSIONS: The present results further support the presence of a dissociative subtype within the DSM-5 criteria for PTSD.
Address Graduate Program in Neuroscience, Western University, London, Ontario, Canada
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Notes PMID:25854673 Approved no
Call Number UU @ jana.mullerova @ Serial 42188
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