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Author Blume-Jensen, P.; Berman, D.M.; Rimm, D.L.; Shipitsin, M.; Putzi, M.; Nifong, T.P.; Small, C.; Choudhury, S.; Capela, T.; Coupal, L.; Ernst, C.; Hurley, A.; Kaprelyants, A.; Chang, H.; Giladi, E.; Nardone, J.; Dunyak, J.; Loda, M.; Klein, E.A.; Magi-Galluzzi, C.; Latour, M.; Epstein, J.I.; Kantoff, P.; Saad, F. url  openurl
  Title Development and clinical validation of an in situ biopsy-based multimarker assay for risk stratification in prostate cancer Type Journal Article
  Year 2015 Publication Abbreviated Journal Clin Cancer Res  
  Volume 21 Issue 11 Pages (down) 2591-2600  
  Keywords  
  Abstract PURPOSE: Prostate cancer aggressiveness and appropriate therapy are routinely determined following biopsy sampling. Current clinical and pathologic parameters are insufficient for accurate risk prediction leading primarily to overtreatment and also missed opportunities for curative therapy. EXPERIMENTAL DESIGN: An 8-biomarker proteomic assay for intact tissue biopsies predictive of prostate pathology was defined in a study of 381 patient biopsies with matched prostatectomy specimens. A second blinded study of 276 cases validated this assay’s ability to distinguish “favorable” versus “nonfavorable” pathology independently and relative to current risk classification systems National Comprehensive Cancer Network (NCCN and D’Amico). RESULTS: A favorable biomarker risk score of ≤0.33, and a nonfavorable risk score of >0.80 (possible range between 0 and 1) were defined on “false-negative” and “false-positive” rates of 10% and 5%, respectively. At a risk score ≤0.33, predictive values for favorable pathology in very low-risk and low-risk NCCN and low-risk D’Amico groups were 95%, 81.5%, and 87.2%, respectively, higher than for these current risk classification groups themselves (80.3%, 63.8%, and 70.6%, respectively). The predictive value for nonfavorable pathology was 76.9% at biomarker risk scores >0.8 across all risk groups. Increased biomarker risk scores correlated with decreased frequency of favorable cases across all risk groups. The validation study met its two coprimary endpoints, separating favorable from nonfavorable pathology (AUC, 0.68; P < 0.0001; OR, 20.9) and GS-6 versus non-GS-6 pathology (AUC, 0.65; P < 0.0001; OR, 12.95). CONCLUSIONS: The 8-biomarker assay provided individualized, independent prognostic information relative to current risk stratification systems, and may improve the precision of clinical decision making following prostate biopsy.  
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  Notes Approved no  
  Call Number UofT @ ankit.sinha @ Serial 45258  
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Author Naslim, N.; Kemper, F.; Madden, S.C.; Hony, S.; Chu, Y.-H.; Galliano, F.; Bot, C.; Yang, Y.; Seok, J.; Oliveira, J.M.; van Loon, J.T.; Meixner, M.; Li, A.; Hughes, A.; Gordon, K.D.; Otsuka, M.; Hirashita, H.; Morata, O.; Lebouteiller, V.; Indebetouw, R.; Srinivasan, S.; Bernard, J.-P.; Reach, W.T. doi  openurl
  Title Molecular hydrogen emission in the interstellar medium of the Large Magellanic Cloud Type Journal Article
  Year 2015 Publication Mon.~Not.~R.~Astron.~Soc. Abbreviated Journal  
  Volume 446 Issue 3 Pages (down) 2490-2504  
  Keywords ISM: molecules; photodissociation region (PDR); galaxies: ISM; Magellanic Cloud; infrared: ISM  
  Abstract We present the detection and analysis of molecular hydrogen emission towards ten interstellar regions in the Large Magellanic Cloud. We examined low-resolution infrared spectral maps of 12 regions obtained with the Spitzer infrared spectrograph (IRS). The pure rotational 0-0 transitions of H2 at 28.2 and 17.1 μm are detected in the IRS spectra for 10 regions. The higher level transitions are mostly upper limit measurements except for three regions, where a 3σ detection threshold is achieved for lines at 12.2 and 8.6 μm. The excitation diagrams of the detected H2 transitions are used to determine the warm H2 gas column density and temperature. The single-temperature fits through the lower transition lines give temperatures in the range 86-137 K. The bulk of the excited H2 gas is found at these temperatures and contributes ˜5-17 per cent to the total gas mass. We find a tight correlation of the H2 surface brightness with polycyclic aromatic hydrocarbon and total infrared emission, which is a clear indication of photoelectric heating in photodissociation regions. We find the excitation of H2 by this process is equally efficient in both atomic- and molecular-dominated regions. We also present the correlation of the warm H2 physical conditions with dust properties. The warm H2 mass fraction and excitation temperature show positive correlations with the average starlight intensity, again supporting H2 excitation in photodissociation regions.  
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  Notes refereed; Owner: ciska; Added to JabRef: 2015.04.15 Approved no  
  Call Number ASIAA @ ciska @ Serial 41815  
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Author Naslim, N.; Kemper, F.; Madden, S.C.; Hony, S.; Chu, Y.-H.; Galliano, F.; Bot, C.; Yang, Y.; Seok, J.; Oliveira, J.M.; van Loon, J.T.; Meixner, M.; Li, A.; Hughes, A.; Gordon, K.D.; Otsuka, M.; Hirashita, H.; Morata, O.; Lebouteiller, V.; Indebetouw, R.; Srinivasan, S.; Bernard, J.-P.; Reach, W.T. doi  openurl
  Title Molecular hydrogen emission in the interstellar medium of the Large Magellanic Cloud Type Journal Article
  Year 2015 Publication Mon.~Not.~R.~Astron.~Soc. Abbreviated Journal  
  Volume 446 Issue 3 Pages (down) 2490-2504  
  Keywords ISM: molecules; photodissociation region (PDR); galaxies: ISM; Magellanic Cloud; infrared: ISM  
  Abstract We present the detection and analysis of molecular hydrogen emission towards ten interstellar regions in the Large Magellanic Cloud. We examined low-resolution infrared spectral maps of 12 regions obtained with the Spitzer infrared spectrograph (IRS). The pure rotational 0-0 transitions of H2 at 28.2 and 17.1 μm are detected in the IRS spectra for 10 regions. The higher level transitions are mostly upper limit measurements except for three regions, where a 3σ detection threshold is achieved for lines at 12.2 and 8.6 μm. The excitation diagrams of the detected H2 transitions are used to determine the warm H2 gas column density and temperature. The single-temperature fits through the lower transition lines give temperatures in the range 86-137 K. The bulk of the excited H2 gas is found at these temperatures and contributes ˜5-17 per cent to the total gas mass. We find a tight correlation of the H2 surface brightness with polycyclic aromatic hydrocarbon and total infrared emission, which is a clear indication of photoelectric heating in photodissociation regions. We find the excitation of H2 by this process is equally efficient in both atomic- and molecular-dominated regions. We also present the correlation of the warm H2 physical conditions with dust properties. The warm H2 mass fraction and excitation temperature show positive correlations with the average starlight intensity, again supporting H2 excitation in photodissociation regions.  
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  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes refereed; Owner: ciska; Added to JabRef: 2015.04.15 Approved no  
  Call Number ASIAA @ ciska @ Serial 42038  
Permanent link to this record
 

 
Author Nicholson, A.A.; Densmore, M.; Frewen, P.A.; Theberge, J.; Neufeld, R.W.; McKinnon, M.C.; Lanius, R.A. url  doi
openurl 
  Title The Dissociative Subtype of Posttraumatic Stress Disorder: Unique Resting-State Functional Connectivity of Basolateral and Centromedial Amygdala Complexes Type Journal Article
  Year 2015 Publication Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology Abbreviated Journal Neuropsychopharmacology  
  Volume 40 Issue 10 Pages (down) 2317-2326  
  Keywords  
  Abstract Previous studies point towards differential connectivity patterns among basolateral (BLA) and centromedial (CMA) amygdala regions in patients with posttraumatic stress disorder (PTSD) as compared with controls. Here we describe the first study to compare directly connectivity patterns of the BLA and CMA complexes between PTSD patients with and without the dissociative subtype (PTSD+DS and PTSD-DS, respectively). Amygdala connectivity to regulatory prefrontal regions and parietal regions involved in consciousness and proprioception were expected to differ between these two groups based on differential limbic regulation and behavioral symptoms. PTSD patients (n=49) with (n=13) and without (n=36) the dissociative subtype and age-matched healthy controls (n=40) underwent resting-state fMRI. Bilateral BLA and CMA connectivity patterns were compared using a seed-based approach via SPM Anatomy Toolbox. Among patients with PTSD, the PTSD+DS group exhibited greater amygdala functional connectivity to prefrontal regions involved in emotion regulation (bilateral BLA and left CMA to the middle frontal gyrus and bilateral CMA to the medial frontal gyrus) as compared with the PTSD-DS group. In addition, the PTSD+DS group showed greater amygdala connectivity to regions involved in consciousness, awareness, and proprioception-implicated in depersonalization and derealization (left BLA to superior parietal lobe and cerebellar culmen; left CMA to dorsal posterior cingulate and precuneus). Differences in amygdala complex connectivity to specific brain regions parallel the unique symptom profiles of the PTSD subgroups and point towards unique biological markers of the dissociative subtype of PTSD.  
  Address Lawson Health Research Institute, Western University, London, Ontario, Canada  
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  ISSN 0893-133X ISBN Medium  
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  Notes PMID:25790021 Approved no  
  Call Number UU @ jana.mullerova @ Serial 42191  
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Author Al-Awqati, Q. url  openurl
  Title Kidney growth and hypertrophy: the role of mTOR and vesicle trafficking Type Journal Article
  Year 2015 Publication Abbreviated Journal J Clin Invest  
  Volume 125 Issue 6 Pages (down) 2267-2270  
  Keywords  
  Abstract The kidney, like other organs, grows in constant proportion to the rest of the body. When one kidney is removed, the remaining one hypertrophies. In a comprehensive series of studies, Chen et al. show that growth during maturation is mediated by the mTORC1 signaling pathway, which is induced by EGF-like peptides, and requires PI3K, PDK, AKT, mTORC2, and activation of mTORC1 through the combined effects of TSC and RHEB as part of a multiprotein complex localized on lysosomes. However, compensatory growth is mediated by amino acids, which act on mTORC1 independently of the previous pathway, and requires a class III PI3K (VPS34) that is known to be involved in vesicle trafficking to the lysosomes.  
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  ISSN 0021-9738 ISBN Medium  
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  Notes Approved no  
  Call Number UofT @ mathieu.lemaire @ Serial 45804  
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Author Gulbahar, O.; Konca Degertekin, C.; Akturk, M.; Yalcin, M.M.; Kalan, I.; Atikeler, G.F.; Altinova, A.E.; Yetkin, I.; Arslan, M.; Toruner, F. url  doi
openurl 
  Title A Case With Immunoassay Interferences in the Measurement of Multiple Hormones Type Journal Article
  Year 2015 Publication The Journal of Clinical Endocrinology and Metabolism Abbreviated Journal J Clin Endocrinol Metab  
  Volume 100 Issue 6 Pages (down) 2147-2153  
  Keywords Adult; Antibodies, Heterophile/*blood; *Artifacts; Cross Reactions; *Diagnostic Techniques, Endocrine/standards; False Positive Reactions; Female; Hormones/*analysis; Humans; Immunoassay/methods; Postpartum Period/blood/immunology  
  Abstract CONTEXT: Commonly used immunoassays are not free from interference, which can be a confounder in the interpretation of test results. We present a case with extremely high multiple hormone levels due to such interference. CASE DESCRIPTION: A 33-year-old woman with no specific symptoms had markedly elevated TSH with normal free T4 and free T3 levels. Repeated measurements revealed discordantly high TSH, ACTH, FSH, PTH, IGF-1, prolactin, beta-human chorionic gonadotropin, and calcitonin levels without the associated clinical pictures. The measurements were repeated with the same patient sample on four different analytical platforms using chemiluminescence immunoassays/electrochemiluminescence immunoassays, and the results were divergent on each platform. Serial dilutions of serum samples revealed nonlinearity, suggesting assay interference. All hormonal measurements were in the normal range when heterophile antibody blocking tubes were used. The serum of the patient was then subjected to polyethylene glycol precipitation. The post-polyethylene glycol recovery resulted in hormone levels in the normal range. The patient did not receive any medications and has been under follow-up without any signs and symptoms for 24 months. CONCLUSIONS: This report illustrates a rare case of falsely elevated hormone levels due to assay interference caused by heterophile antibodies. We point out the importance of a close collaboration between clinicians and the laboratory to avoid unnecessary clinical investigations as well as inappropriate treatments.  
  Address Departments of Biochemistry (O.G., G.F.A.) and Endocrinology and Metabolism (C.K.D., M.A., M.M.Y., I.K., A.E.A., I.Y., M.A., F.T.), Gazi University Faculty of Medicine, 06100 Ankara, Turkey  
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  ISSN 0021-972X ISBN Medium  
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  Notes PMID:25897621 Approved no  
  Call Number QEHB @ isla.wootton @ Serial 42160  
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Author Chiolerio, A.; Roppolo, I.; Cauda, V.; Crepaldi, M.; Bocchini, S.; Bejtka, K.; Verna, A.; Pirri, C.F. url  openurl
  Title Ultraviolet mem-sensors: flexible anisotropic composites featuring giant photocurrent enhancement Type Journal Article
  Year 2015 Publication Abbreviated Journal Nano Research  
  Volume 8 Issue 6 Pages (down) 1956-1963  
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  Notes Cited By :6; Export Date: 2 November 2016 Approved no  
  Call Number IIT-CSF @ alessandro.chiolerio @ Serial 42778  
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Author Andrade-Oliveira, V.; Amano, M.T.; Correa-Costa, M.; Castoldi, A.; Felizardo, R.J.; de Almeida, D.C.; Bassi, E.J.; Moraes-Vieira, P.M.; Hiyane, M.I.; Rodas, A.C.; Peron, J.P.; Aguiar, C.F.; Reis, M.A.; Ribeiro, W.R.; Valduga, C.J.; Curi, R.; Vinolo, M.A.; Ferreira, C.M.; Câmara, N.O. url  openurl
  Title Gut Bacteria Products Prevent AKI Induced by Ischemia-Reperfusion Type Journal Article
  Year 2015 Publication Abbreviated Journal J Am Soc Nephrol  
  Volume 26 Issue 8 Pages (down) 1877-1888  
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  Abstract Short-chain fatty acids (SCFAs) are fermentation end products produced by the intestinal microbiota and have anti-inflammatory and histone deacetylase-inhibiting properties. Recently, a dual relationship between the intestine and kidneys has been unraveled. Therefore, we evaluated the role of SCFA in an AKI model in which the inflammatory process has a detrimental role. We observed that therapy with the three main SCFAs (acetate, propionate, and butyrate) improved renal dysfunction caused by injury. This protection was associated with low levels of local and systemic inflammation, oxidative cellular stress, cell infiltration/activation, and apoptosis. However, it was also associated with an increase in autophagy. Moreover, SCFAs inhibited histone deacetylase activity and modulated the expression levels of enzymes involved in chromatin modification. In vitro analyses showed that SCFAs modulated the inflammatory process, decreasing the maturation of dendritic cells and inhibiting the capacity of these cells to induce CD4(+) and CD8(+) T cell proliferation. Furthermore, SCFAs ameliorated the effects of hypoxia in kidney epithelial cells by improving mitochondrial biogenesis. Notably, mice treated with acetate-producing bacteria also had better outcomes after AKI. Thus, we demonstrate that SCFAs improve organ function and viability after an injury through modulation of the inflammatory process, most likely via epigenetic modification.  
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  ISSN 1046-6673 ISBN Medium  
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  Notes Approved no  
  Call Number UofT @ mathieu.lemaire @ Serial 45839  
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Author Gadagkar, R. openurl 
  Title How should biologists engage with controversial mathematical theory? Type Journal Article
  Year 2015 Publication Abbreviated Journal Current Science  
  Volume 108 Issue 10 Pages (down) 1869-1873  
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  Call Number CES @ dilipnaidu.gt @ Serial 43034  
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Author Borges, R.M. openurl 
  Title How mutualisms between plants and insects are stabilized Type Journal Article
  Year 2015 Publication Abbreviated Journal Current Science  
  Volume 108 Issue 10 Pages (down) 1862-1868  
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  Notes Approved no  
  Call Number CES @ dilipnaidu.gt @ Serial 43028  
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