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Author Datta-Roy, A.; Deepak, V.; Sidharthan, C.; Barley, A.J.; Praveen, K. openurl 
  Title An addition to the endemic Indian radiation of Eutropis: Phylogenetic position of Eutropis dissimilis Hallowell (Squamata: Scincidae) Type Journal Article
  Year 2015 Publication Abbreviated Journal Zootaxa  
  Volume 4027 Issue 1 Pages 145-150  
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  ISSN 1175-5334 ISBN Medium  
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  Notes Approved no  
  Call Number CES @ dilipnaidu.gt @ Serial 43106  
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Author Krishnan, A.; Ghara, M.; Kasinathan, S.; Pramanik, G.K.; Revadi, S.; Borges, R.M. doi  openurl
  Title Plant reproductive traits mediate tritrophic feedback effects within an obligate brood-site pollination mutualism Type Journal Article
  Year 2015 Publication Abbreviated Journal Oecologia  
  Volume 179 Issue 3 Pages 797-809  
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  Abstract Plants, herbivores and parasitoids affect each other directly and indirectly; however, feedback effects mediated by host plant traits have rarely been demonstrated in these tritrophic interactions. Brood-site pollination mutualisms (e.g. those involving figs and fig wasps) represent specialised tritrophic communities where the progeny of mutualistic pollinators and of non-mutualistic gallers (both herbivores) together with that of their parasitoids develop within enclosed inflorescences called syconia (hence termed brood-sites or microcosms). Plant reproductive phenology (which affects temporal brood-site availability) and inflorescence size (representing brood-site size) are plant traits that could affect reproductive resources, and hence relationships between trees, pollinators and non-pollinating wasps. Analysing wasp and seed contents of syconia, we examined direct, indirect, trophic and non-trophic relationships within the interaction web of the fig–fig wasp community of Ficus racemosa in the context of brood site size and availability. We demonstrate that in addition to direct resource competition and predator–prey (host–parasitoid) interactions, these communities display exploitative or apparent competition and trait-mediated indirect interactions. Inflorescence size and plant reproductive phenology impacted plant–herbivore and plant–parasitoid associations. These plant traits also influenced herbivore–herbivore and herbivore–parasitoid relationships via indirect effects. Most importantly, we found a reciprocal effect between within-tree reproductive asynchrony and fig wasp progeny abundances per syconium that drives a positive feedback cycle within the system. The impact of a multitrophic feedback cycle within a community built around a mutualistic core highlights the need for a holistic view of plant–herbivore–parasitoid interactions in the community ecology of mutualisms.  
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  ISSN 1432-1939 ISBN Medium  
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  Call Number CES @ dilipnaidu.gt @ Serial 43113  
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Author Dinesh, K.P.; Vijayakumar, S.P.; Channakeshavamurthy, B.H.; Toreskar, V.R.; Kulkarni, N.U.; Shanker, K. openurl 
  Title Systematic status of Fejervarya (Amphibia, Anura, Dicroglossidae) from South and SE Asia with the description of a new species from the Western Ghats of Peninsular India Type Journal Article
  Year 2015 Publication Abbreviated Journal Zootaxa  
  Volume 3999 Issue 1 Pages 079-094  
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  Call Number CES @ dilipnaidu.gt @ Serial 43132  
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Author Borges, R.M. openurl 
  Title Fruit and Seed Volatiles: Multiple Stage Settings, Actors and Props in an Evolutionary Play Type Journal Article
  Year 2015 Publication Abbreviated Journal Journal of the Indian Institute of Science  
  Volume 95 Issue 1 Pages 93-104  
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  Series Volume Series Issue Edition  
  ISSN 0970-4140 ISBN Medium  
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  Call Number CES @ dilipnaidu.gt @ Serial 43137  
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Author Bhaduri, A.; Raghavendra, S.; Guttal, V. doi  openurl
  Title On the Systemic Fragility of Finance-Led Growth Type Journal Article
  Year 2015 Publication Abbreviated Journal Metroeconomica  
  Volume 66 Issue 1 Pages 158-186  
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  ISSN 1467-999x ISBN Medium  
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  Call Number CES @ dilipnaidu.gt @ Serial 43139  
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Author Skirnisdottir, I.; Seidal, T.; Åkerud, H. url  openurl
  Title Differences in Clinical and Biological Features Between Type I and Type II Tumors in FIGO Stages I-II Epithelial Ovarian Carcinoma Type Journal Article
  Year 2015 Publication Abbreviated Journal Int J Gynecol Cancer  
  Volume 25 Issue 7 Pages 1239-1247  
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  Abstract OBJECTIVE: The objective of this study was to compare immunohistochemical profile for the apoptosis regulators p53, C-MYC, bax, PUMA, and PTEN and the cell cycle regulatory proteins p21 and p27, as well as clinical factors between types I and II tumors. METHODS: In total, 131 patients in FIGO (International Federation of Gynecology and Obstetrics) stages I-II were divided into 2 groups of patients after type I tumors (n = 79) and type II tumors (n = 52). Differences in the immunohistochemical profile for the cell cycle-related proteins, detected by tissue microarrays and immune-histochemistry, were compared. For statistical tests, the Pearson χ test and the logistic regression model were used. All tests were 2-sided, and the level of statistical significance was P ≤ 0.05. RESULTS: In multivariate logistic regression analysis with recurrent disease as endpoint, FIGO stage (odds ratio [OR], 4.7), type I/II tumors (OR, 3.8), body mass index (BMI) (OR, 3.5), and p53 status (OR, 4.2) all were found to be independent predictive factors. In 2 different multivariate logistic regression analyses with type I/II tumors as endpoint, both p53p21 (OR, 2.9) and p27 status (OR, 3.0) were associated with type II tumors. Differently, C-MYC status (OR, 0.4) was associated with type I tumors. Furthermore, age (OR, 1.04), BMI (OR, 0.4), and recurrent disease (OR, 4.3) all were associated to type II tumors. In survival analysis, there was a trend (P = 0.054) toward better disease-free survival for patients with type I tumors. CONCLUSIONS: Concomitant positivity for p53 and negativity for p21, positivity for p27, and negativity for C-MYC in an epithelial ovarian tumor might strengthen the diagnostic option of type II tumor ovarian carcinoma. Patients with type II tumors were older, had lower BMI, and had more often recurrent disease than patients with type I tumors.  
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  Call Number UofT @ ankit.sinha @ Serial 44930  
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Author Ng, A.; Barker, N. url  openurl
  Title Ovary and fimbrial stem cells: biology, niche and cancer origins Type Journal Article
  Year 2015 Publication Abbreviated Journal Nat Rev Mol Cell Biol  
  Volume 16 Issue 10 Pages 625-638  
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  Abstract The mammalian ovary is covered by a single-layered epithelium that undergoes rupture and remodelling following each ovulation. Although resident stem cells are presumed to be crucial for this cyclic regeneration, their identity and mode of action have been elusive. Surrogate stemness assays and in vivo fate-mapping studies using recently discovered stem cell markers have identified stem cell pools in the ovary and fimbria that ensure epithelial homeostasis. Recent findings provide insights into intrinsic mechanisms and local extrinsic cues that govern the function of ovarian and fimbrial stem cells. These discoveries have advanced our understanding of stem cell biology in the ovary and fimbria, and lay the foundations for evaluating the contribution of resident stem cells to the initiation and progression of human epithelial ovarian cancer.  
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  Call Number UofT @ ankit.sinha @ Serial 44935  
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Author Hunter, S.M.; Anglesio, M.S.; Ryland, G.L.; Sharma, R.; Chiew, Y.E.; Rowley, S.M.; Doyle, M.A.; Li, J.; Gilks, C.B.; Moss, P.; Allan, P.E.; Stephens, A.N.; Huntsman, D.G.; deFazio, A.; Bowtell, D.D.; Australian, O.C.S.G.; Gorringe, K.L.; Campbell, I.G. url  openurl
  Title Molecular profiling of low grade serous ovarian tumours identifies novel candidate driver genes Type Journal Article
  Year 2015 Publication Abbreviated Journal Oncotarget  
  Volume 6 Issue 35 Pages 37663-37677  
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  Abstract Low grade serous ovarian tumours are a rare and under-characterised histological subtype of epithelial ovarian tumours, with little known of the molecular drivers and facilitators of tumorigenesis beyond classic oncogenic RAS/RAF mutations. With a move towards targeted therapies due to the chemoresistant nature of this subtype, it is pertinent to more fully characterise the genetic events driving this tumour type, some of which may influence response to therapy and/or development of drug resistance. We performed genome-wide high-resolution genomic copy number analysis (Affymetrix SNP6.0) and mutation hotspot screening (KRAS, BRAF, NRAS, HRAS, ERBB2 and TP53) to compare a large cohort of ovarian serous borderline tumours (SBTs, n = 57) with low grade serous carcinomas (LGSCs, n = 19). Whole exome sequencing was performed for 13 SBTs, nine LGSCs and one mixed low/high grade carcinoma. Copy number aberrations were detected in 61% (35/57) of SBTs, compared to 100% (19/19) of LGSCs. Oncogenic RAS/RAF/ERBB2 mutations were detected in 82.5% (47/57) of SBTs compared to 63% (12/19) of LGSCs, with NRAS mutations detected only in LGSC. Some copy number aberrations appeared to be enriched in LGSC, most significantly loss of 9p and homozygous deletions of the CDKN2A/2B locus. Exome sequencing identified BRAF, KRAS, NRAS, USP9X and EIF1AX as the most frequently mutated genes. We have identified markers of progression from borderline to LGSC and novel drivers of LGSC. USP9X and EIF1AX have both been linked to regulation of mTOR, suggesting that mTOR inhibitors may be a key companion treatment for targeted therapy trials of MEK and RAF inhibitors.  
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  Call Number UofT @ ankit.sinha @ Serial 44942  
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Author Kampan, N.C.; Madondo, M.T.; McNally, O.M.; Quinn, M.; Plebanski, M. url  openurl
  Title Paclitaxel and Its Evolving Role in the Management of Ovarian Cancer Type Journal Article
  Year 2015 Publication Abbreviated Journal Biomed Res Int  
  Volume 2015 Issue Pages 413076  
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  Abstract Paclitaxel, a class of taxane with microtubule stabilising ability, has remained with platinum based therapy, the standard care for primary ovarian cancer management. A deeper understanding of the immunological basis and other potential mechanisms of action together with new dosing schedules and/or routes of administration may potentiate its clinical benefit. Newer forms of taxanes, with better safety profiles and higher intratumoural cytotoxicity, have yet to demonstrate clinical superiority over the parent compound.  
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  Call Number UofT @ ankit.sinha @ Serial 45056  
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Author Wright, A.A.; Cronin, A.; Milne, D.E.; Bookman, M.A.; Burger, R.A.; Cohn, D.E.; Cristea, M.C.; Griggs, J.J.; Keating, N.L.; Levenback, C.F.; Mantia-Smaldone, G.; Matulonis, U.A.; Meyer, L.A.; Niland, J.C.; Weeks, J.C.; O’Malley, D.M. url  openurl
  Title Use and Effectiveness of Intraperitoneal Chemotherapy for Treatment of Ovarian Cancer Type Journal Article
  Year 2015 Publication Abbreviated Journal J Clin Oncol  
  Volume 33 Issue 26 Pages 2841-2847  
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  Abstract PURPOSE: A 2006 randomized trial demonstrated a 16-month survival benefit with intraperitoneal and intravenous (IP/IV) chemotherapy administered to patients who had ovarian cancer, compared with IV chemotherapy alone, but more treatment-related toxicities. The objective of this study was to examine the use and effectiveness of IP/IV chemotherapy in clinical practice. PATIENTS AND METHODS: Prospective cohort study of 823 women with stage III, optimally cytoreduced ovarian cancer diagnosed at six National Comprehensive Cancer Network institutions. We examined IP/IV chemotherapy use in all patients diagnosed between 2003 and 2012 (N = 823), and overall survival and treatment-related toxicities with Cox regression and logistic regression, respectively, in a propensity score-matched sample (n = 402) of patients diagnosed from 2006 to 2012, excluding trial participants, to minimize selection bias. RESULTS: Use of IP/IV chemotherapy increased from 0% to 33% between 2003 and 2006, increased to 50% from 2007 to 2008, and plateaued thereafter. Between 2006 and 2012, adoption of IP/IV chemotherapy varied by institution from 4% to 67% (P <.001) and 43% of patients received modified IP/IV regimens at treatment initiation. In the propensity score-matched sample, IP/IV chemotherapy was associated with significantly improved overall survival (3-year overall survival, 81% v 71%; hazard ratio, 0.68; 95% CI, 0.47 to 0.99), compared with IV chemotherapy, but also more frequent alterations in chemotherapy delivery route (adjusted rates discontinuation or change, 20.4% v 10.0%; adjusted odds ratio, 2.83; 95% CI, 1.47 to 5.47). CONCLUSION: Although the use of IP/IV chemotherapy increased significantly at National Comprehensive Cancer Network centers between 2003 and 2012, fewer than 50% of eligible patients received it. Increasing IP/IV chemotherapy use in clinical practice may be an important and underused strategy to improve ovarian cancer outcomes.  
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  Call Number UofT @ ankit.sinha @ Serial 45060  
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