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Author Birch, J. L. url  doi
openurl 
  Title (up) A revision of infrageneric classification in Astelia Banks & Sol. ex R.Br. (Asteliaceae) Type Journal Article
  Year 2015 Publication PhytoKeys Abbreviated Journal  
  Volume 52 Issue Pages 105-132  
  Keywords  
  Abstract Systematic investigations and phylogenetic analyses have indicated that Astelia, as currently circumscribed, is paraphyletic, with Collospermum nested within it. Further, A. subgenus Astelia is polyphyletic, and A. subgenera Asteliopsis and Tricella are paraphyletic, as currently circumscribed. Revision of the subgeneric classification of Astelia is warranted to ensure classification accurately reflects the evolutionary history of these taxa. Collospermum is relegated to synonymy within Astelia. Astelia is dioecious or polygamodioecious, with a superior ovary, anthers dorsi- or basifixed, pistillodes or pistils that have a single short or poorly defined style, a 3 lobed stigma, and fleshy uni- or trilocular fruit with funicular hairs that are poorly to well developed. Astelia subgenus Collospermum (Skottsb.) Birch is described. A key to Astelia sections is provided. Astelia hastata Colenso, A. montana Seem., and A. microsperma Colenso pro parte are resurrected and the new combination A. samoense (Skottsb.) Birch, comb. nov. is made.  
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  Publisher Pensoft Place of Publication Editor  
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  Notes Approved no  
  Call Number NYBG @ sthackurdeen @ Serial 42161  
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Author Kerr, G.; Sheldon, H.; Chaikuad, A.; Alfano, I.; Delft, F. von; Bullock, A.N.; Harris, A.L. openurl 
  Title (up) A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis Type Journal Article
  Year 2015 Publication Abbreviated Journal Angiogenesis  
  Volume 18 Issue 2 Pages 209--217  
  Keywords Type II,Chick Embryo,Growth Differentiation Factor 2,Growth Differentiation Factors,Human Umbilical Vein Endothelial Cells,Humans,Neovascularization,Physiologic,Phenols,Protein Kinase Inhibitors,Receptors,Notch  
  Abstract Activin receptor-like kinase 1 (ALK1, encoded by the gene ACVRL1) is a type I BMP/TGF-ß receptor that mediates signalling in endothelial cells via phosphorylation of SMAD1/5/8. During angiogenesis, sprouting endothelial cells specialise into tip cells and stalk cells. ALK1 synergises with Notch in stalk cells to induce expression of the Notch targets HEY1 and HEY2 and thereby represses tip cell formation and angiogenic sprouting. The ALK1-Fc soluble protein fusion has entered clinic trials as a therapeutic strategy to sequester the high-affinity extracellular ligand BMP9. Here, we determined the crystal structure of the ALK1 intracellular kinase domain and explored the effects of a small molecule kinase inhibitor K02288 on angiogenesis. K02288 inhibited BMP9-induced phosphorylation of SMAD1/5/8 in human umbilical vein endothelial cells to reduce both the SMAD and the Notch-dependent transcriptional responses. In endothelial sprouting assays, K02288 treatment induced a hypersprouting phenotype reminiscent of Notch inhibition. Furthermore, K02288 caused dysfunctional vessel formation in a chick chorioallantoic membrane assay of angiogenesis. Such activity may be advantageous for small molecule inhibitors currently in preclinical development for specific BMP gain of function conditions, including diffuse intrinsic pontine glioma and fibrodysplasia ossificans progressiva, as well as more generally for other applications in tumour biology.  
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  ISSN 1573-7209 ISBN Medium  
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  Notes Approved no  
  Call Number AG @ matthewjvarga @ Serial 46992  
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Author Jones, O.C.; McDonald, I.; Rich, R.M.; Kemper, F.; Boyer, M.L.; Zijlstra, A.A.; Bendo, G.J. url  openurl
  Title (up) A Spitzer Space Telescope survey of extreme asymptotic giant branch stars in M32 Type Journal Article
  Year 2015 Publication Mon.~Not.~R.~Astron.~Soc. Abbreviated Journal  
  Volume 446 Issue 2 Pages 1584-1596  
  Keywords stars: AGB and post-AGB; stars: late-type; stars: mass-loss; galaxies: individual: M32; galaxies: stellar content; infrared: stars  
  Abstract We investigate the population of cool, evolved stars in the Local Group dwarf elliptical galaxy M32, using Infrared Array Camera observations from the Spitzer Space Telescope. We construct deep mid-infrared colour-magnitude diagrams for the resolved stellar populations within 3.5 arcmin of M32's centre, and identify those stars that exhibit infrared excess. Our data are dominated by a population of luminous, dust-producing stars on the asymptotic giant branch (AGB) and extend to approximately 3 mag below the AGB tip. We detect for the first time a sizeable population of `extreme' AGB stars, highly enshrouded by circumstellar dust and likely completely obscured at optical wavelengths. The total dust-injection rate from the extreme AGB candidates is measured to be 7.5 × 10-7 M⊙ yr-1, corresponding to a gas mass-loss rate of 1.5 × 10-4 M⊙ yr-1. These extreme stars may be indicative of an extended star formation epoch between 0.2 and 5 Gyr ago.  
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  Notes refereed; Owner: ciska; Added to JabRef: 2015.04.15 Approved no  
  Call Number ASIAA @ ciska @ Serial 41992  
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Author Korsgaard, S.; Berglund, H.; Thrane, C.; Blenker, P. doi  openurl
  Title (up) A Tale of Two Kirzners: Time, Uncertainty, and the “Nature” of Opportunities Type Journal Article
  Year 2015 Publication Entrepreneurship Theory and Practice Abbreviated Journal Entrepreneurship Theory and Practice  
  Volume Issue Pages n/a-n/a  
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  Abstract This paper discusses the influence of Israel Kirzner on the field of entrepreneurship research. We review Kirzner's work and argue that it contains two distinct approaches to entrepreneurship, termed Kirzner Mark I and Kirzner Mark II. Mark I with its focus on alertness and opportunity discovery has exerted a strong influence on entrepreneurship research in the last decade, and helped catapult the field forward. We propose that Mark II, with its emphasis on time, uncertainty, and creative action in pursuit of imagined opportunities, complements the discovery view and can provide an alternative conceptual grounding for the decade to come.  
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  ISSN 1540-6520 ISBN Medium  
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  Notes Approved no  
  Call Number ATM @ robstephens13 @ Serial 41386  
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Author Deepak, V.; Vyas, R.; Giri, V.B.; Karanth, K.P. openurl 
  Title (up) A taxonomic mystery for more than 180 years: the identity and systematic position of Brachysaura minor (HARDWICKE & GRAY, 1827) Type Journal Article
  Year 2015 Publication Abbreviated Journal Vertebrate Zoology  
  Volume 65 Issue 3 Pages 371-381  
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  Series Volume Series Issue Edition  
  ISSN 1864-5755 ISBN Medium  
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  Notes Approved no  
  Call Number CES @ dilipnaidu.gt @ Serial 43033  
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Author Andersson, R.; Sandelin, A.; Danko, C.G. url  openurl
  Title (up) A unified architecture of transcriptional regulatory elements Type Journal Article
  Year 2015 Publication Abbreviated Journal Trends Genet  
  Volume 31 Issue 8 Pages 426-433  
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  Abstract Gene expression is precisely controlled in time and space through the integration of signals that act at gene promoters and gene-distal enhancers. Classically, promoters and enhancers are considered separate classes of regulatory elements, often distinguished by histone modifications. However, recent studies have revealed broad similarities between enhancers and promoters, blurring the distinction: active enhancers often initiate transcription, and some gene promoters have the potential to enhance transcriptional output of other promoters. Here, we propose a model in which promoters and enhancers are considered a single class of functional element, with a unified architecture for transcription initiation. The context of interacting regulatory elements and the surrounding sequences determine local transcriptional output as well as the enhancer and promoter activities of individual elements.  
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  ISSN 0168-9525 ISBN Medium  
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  Notes Approved no  
  Call Number UofT @ mathieu.lemaire @ Serial 45626  
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Author Albers, J.; Danzer, C.; Rechsteiner, M.; Lehmann, H.; Brandt, L.P.; Hejhal, T.; Catalano, A.; Busenhart, P.; Gonçalves, A.F.; Brandt, S.; Bode, P.K.; Bode-Lesniewska, B.; Wild, P.J.; Frew, I.J. url  openurl
  Title (up) A versatile modular vector system for rapid combinatorial mammalian genetics Type Journal Article
  Year 2015 Publication Abbreviated Journal J Clin Invest  
  Volume 125 Issue 4 Pages 1603-1619  
  Keywords Animals; Apoptosis; Caspase 9; Cells, Cultured; Cloning, Molecular; Clustered Regularly Interspaced Short Palindromic Repeats; Doxycycline; Drug Resistance; Gene Deletion; Gene Knockdown Techniques; Genetic Vectors; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lentivirus; Mice; Mice, SCID; PTEN Phosphohydrolase; Recombination, Genetic; research support, non-u.s. gov’t; Retinoblastoma Protein; RNA, Small Interfering; Sarcoma, Experimental; Transduction, Genetic; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays; Cas9/CRIPSR; Journal club  
  Abstract Here, we describe the multiple lentiviral expression (MuLE) system that allows multiple genetic alterations to be introduced simultaneously into mammalian cells. We created a toolbox of MuLE vectors that constitute a flexible, modular system for the rapid engineering of complex polycistronic lentiviruses, allowing combinatorial gene overexpression, gene knockdown, Cre-mediated gene deletion, or CRISPR/Cas9-mediated (where CRISPR indicates clustered regularly interspaced short palindromic repeats) gene mutation, together with expression of fluorescent or enzymatic reporters for cellular assays and animal imaging. Examples of tumor engineering were used to illustrate the speed and versatility of performing combinatorial genetics using the MuLE system. By transducing cultured primary mouse cells with single MuLE lentiviruses, we engineered tumors containing up to 5 different genetic alterations, identified genetic dependencies of molecularly defined tumors, conducted genetic interaction screens, and induced the simultaneous CRISPR/Cas9-mediated knockout of 3 tumor-suppressor genes. Intramuscular injection of MuLE viruses expressing oncogenic H-RasG12V together with combinations of knockdowns of the tumor suppressors cyclin-dependent kinase inhibitor 2A (Cdkn2a), transformation-related protein 53 (Trp53), and phosphatase and tensin homolog (Pten) allowed the generation of 3 murine sarcoma models, demonstrating that genetically defined autochthonous tumors can be rapidly generated and quantitatively monitored via direct injection of polycistronic MuLE lentiviruses into mouse tissues. Together, our results demonstrate that the MuLE system provides genetic power for the systematic investigation of the molecular mechanisms that underlie human diseases.  
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  ISSN 0021-9738 ISBN Medium  
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  Notes Approved no  
  Call Number UofT @ mathieu.lemaire @ Serial 45848  
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Author ACMG, B. of D. url  openurl
  Title (up) ACMG policy statement: updated recommendations regarding analysis and reporting of secondary findings in clinical genome-scale sequencing Type Journal Article
  Year 2015 Publication Abbreviated Journal Genet Med  
  Volume 17 Issue 1 Pages 68-69  
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  Abstract DISCLAIMER: These recommendations are designed primarily as an educational resource for medical geneticists and other health-care providers to help them provide quality medical genetics services. Adherence to these recommendations does not necessarily ensure a successful medical outcome. These recommendations should not be considered inclusive of all proper procedures and tests or exclusive of other procedures and tests that are reasonably directed to obtaining the same results. In determining the propriety of any specific procedure or test, geneticists and other clinicians should apply their own professional judgment to the specific clinical circumstances presented by the individual patient or specimen. It may be prudent, however, to document in the patient’s record the rationale for any significant deviation from these recommendations.  
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  ISSN 1098-3600 ISBN Medium  
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  Notes Approved no  
  Call Number UofT @ mathieu.lemaire @ Serial 45436  
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Author Amendola, L.M.; Dorschner, M.O.; Robertson, P.D.; Salama, J.S.; Hart, R.; Shirts, B.H.; Murray, M.L.; Tokita, M.J.; Gallego, C.J.; Kim, D.S.; Bennett, J.T.; Crosslin, D.R.; Ranchalis, J.; Jones, K.L.; Rosenthal, E.A.; Jarvik, E.R.; Itsara, A.; Turner, E.H.; Herman, D.S.; Schleit, J.; Burt, A.; Jamal, S.M.; Abrudan, J.L.; Johnson, A.D.; Conlin, L.K.; Dulik, M.C.; Santani, A.; Metterville, D.R.; Kelly, M.; Foreman, A.K.; Lee, K.; Taylor, K.D.; Guo, X.; Crooks, K.; Kiedrowski, L.A.; Raffel, L.J.; Gordon, O.; Machini, K.; Desnick, R.J.; Biesecker, L.G.; Lubitz, S.A.; Mulchandani, S.; Cooper, G.M.; Joffe, S.; Richards, C.S.; Yang, Y.; Rotter, J.I.; Rich, S.S.; O’Donnell, C.J.; Berg, J.S.; Spinner, N.B.; Evans, J.P.; Fullerton, S.M.; Leppig, K.A.; Bennett, R.L.; Bird, T.; Sybert, V.P.; Grady, W.M.; Tabor, H.K.; Kim, J.H.; Bamshad, M.J.; Wilfond, B.; Motulsky, A.G.; Scott, C.R.; Pritchard, C.C.; Walsh, T.D.; Burke, W.; Raskind, W.H.; Byers, P.; Hisama, F.M.; Rehm, H.; Nickerson, D.A.; Jarvik, G.P. url  openurl
  Title (up) Actionable exomic incidental findings in 6503 participants: challenges of variant classification Type Journal Article
  Year 2015 Publication Abbreviated Journal Genome Res  
  Volume 25 Issue 3 Pages 305-315  
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  Abstract Recommendations for laboratories to report incidental findings from genomic tests have stimulated interest in such results. In order to investigate the criteria and processes for assigning the pathogenicity of specific variants and to estimate the frequency of such incidental findings in patients of European and African ancestry, we classified potentially actionable pathogenic single-nucleotide variants (SNVs) in all 4300 European- and 2203 African-ancestry participants sequenced by the NHLBI Exome Sequencing Project (ESP). We considered 112 gene-disease pairs selected by an expert panel as associated with medically actionable genetic disorders that may be undiagnosed in adults. The resulting classifications were compared to classifications from other clinical and research genetic testing laboratories, as well as with in silico pathogenicity scores. Among European-ancestry participants, 30 of 4300 (0.7%) had a pathogenic SNV and six (0.1%) had a disruptive variant that was expected to be pathogenic, whereas 52 (1.2%) had likely pathogenic SNVs. For African-ancestry participants, six of 2203 (0.3%) had a pathogenic SNV and six (0.3%) had an expected pathogenic disruptive variant, whereas 13 (0.6%) had likely pathogenic SNVs. Genomic Evolutionary Rate Profiling mammalian conservation score and the Combined Annotation Dependent Depletion summary score of conservation, substitution, regulation, and other evidence were compared across pathogenicity assignments and appear to have utility in variant classification. This work provides a refined estimate of the burden of adult onset, medically actionable incidental findings expected from exome sequencing, highlights challenges in variant classification, and demonstrates the need for a better curated variant interpretation knowledge base.  
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  ISSN 1088-9051 ISBN Medium  
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  Notes Approved no  
  Call Number UofT @ mathieu.lemaire @ Serial 45831  
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Author Calignano, F.; Tommasi, T.; Manfredi, D.; Chiolerio, A. url  openurl
  Title (up) Additive Manufacturing of a Microbial Fuel Cell – A detailed study Type Journal Article
  Year 2015 Publication Abbreviated Journal Scientific Reports  
  Volume 5 Issue Pages  
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  Notes Cited By :1; Export Date: 2 November 2016 Approved no  
  Call Number IIT-CSF @ alessandro.chiolerio @ Serial 42774  
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