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Author Tzannidakis, N.C.A.; Frewen, P. url  doi
openurl 
  Title Trauma-Related Altered States of Consciousness (TRASC) and Functional Impairment II: Perceived Causal Relationships in an Online Sample Type Journal Article
  Year 2015 Publication Journal of Trauma & Dissociation : the Official Journal of the International Society for the Study of Dissociation (ISSD) Abbreviated Journal J Trauma Dissociation  
  Volume (down) 16 Issue 5 Pages 520-540  
  Keywords 4-D model; childhood abuse and neglect; dissociation; posttraumatic stress disorder; trauma-related altered states of consciousness  
  Abstract Research supports the existence of a dissociative subtype of posttraumatic stress disorder, although studies have not directly compared the perceived impact of dissociative versus nondissociative posttraumatic symptoms on social and occupational functioning. In addition, research is beginning to differentiate between posttraumatic distress associated with normal waking consciousness (NWC) and dissociative experiences of trauma-related altered states of consciousness (TRASC) along multiple phenomenological dimensions. The current study investigated perceived causal relationships between posttraumatic symptoms associated with NWC-distress and TRASC on the one hand and interpersonal and occupational functioning on the other. Although both TRASC and NWC-distress independently accounted for variance in self-reported interpersonal and occupational problems, perceived causal relationship results showed that individuals tended to attribute their social and work-related problems more strongly to NWC-distress than to TRASC. Future research directions are discussed.  
  Address b Departments of Psychology and Psychiatry and Graduate Program in Neuroscience , Western University , London , Ontario , Canada  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1529-9732 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26308190 Approved no  
  Call Number UU @ jana.mullerova @ Serial 42175  
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Author Defrin, R.; Schreiber, S.; Ginzburg, K. url  doi
openurl 
  Title Paradoxical Pain Perception in Posttraumatic Stress Disorder: The Unique Role of Anxiety and Dissociation Type Journal Article
  Year 2015 Publication The Journal of Pain : Official Journal of the American Pain Society Abbreviated Journal J Pain  
  Volume (down) 16 Issue 10 Pages 961-970  
  Keywords Chronic pain; anxiety; dissociation; hyperresponsiveness; hypoalgesia; posttraumatic stress disorder; psychophysics  
  Abstract Posttraumatic stress disorder (PTSD) and chronic pain often co-occur and exacerbate each other. Elucidating the mechanism of this co-occurrence therefore has clinical importance. Previously, patients with PTSD with chronic pain were found to demonstrate a unique paradoxical pain profile: hyperresponsiveness together with hyposensitivity to pain. Our aim was to examine whether 2 seemingly paradoxical facets of PTSD (anxiety and dissociation) underlie this paradoxical profile. Patients with PTSD (n = 32) and healthy control individuals (n = 43) underwent psychophysical testing and completed questionnaires. Patients with PTSD had higher pain thresholds and higher pain ratings to suprathreshold stimuli than control individuals. Pain thresholds were positively associated with dissociation levels and negatively associated with anxiety sensitivity levels. Experimental pain ratings were positively associated with anxiety sensitivity and negatively related to dissociation levels. Chronic pain intensity was associated with anxiety, anxiety sensitivity, and pain catastrophizing. It appears that reduced conscious attention toward incoming stimuli, resulting from dissociation, causes delayed response in pain threshold measurement, whereas biases toward threatening stimuli and decreased inhibition, possibly caused by increased anxiety, are responsible for the intensification of experimental and chronic pain. The paradoxical facets of PTSD and their particular influences over pain perception seem to reinforce the coexistence of PTSD and chronic pain, and should be considered when treating traumatized individuals. PERSPECTIVE: This article provides new information regarding the underlying mechanism of the coexistence of PTSD and chronic pain. This knowledge could help to provide better management of PTSD and chronic pain among individuals in the aftermath of trauma.  
  Address Bob Shapell School of Social Work, Tel-Aviv University, Tel-Aviv, Israel  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1526-5900 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26168878 Approved no  
  Call Number UU @ jana.mullerova @ Serial 42177  
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Author van Dijke, A.; Ford, J.D.; Frank, L.E.; van der Hart, O. url  doi
openurl 
  Title Association of Childhood Complex Trauma and Dissociation With Complex Posttraumatic Stress Disorder Symptoms in Adulthood Type Journal Article
  Year 2015 Publication Journal of Trauma & Dissociation : the Official Journal of the International Society for the Study of Dissociation (ISSD) Abbreviated Journal J Trauma Dissociation  
  Volume (down) 16 Issue 4 Pages 428-441  
  Keywords childhood trauma; complex posttraumatic stress disorder; dissociation  
  Abstract This study replicates and extends prior research on the relationship of childhood complex trauma (CCT) and complex posttraumatic stress disorder (cPTSD) in adulthood, examining the role of psychoform and somatoform dissociation as a potential mediator. CCT, dissociation, and cPTSD were assessed in a large sample of adult psychiatric inpatients. Almost two thirds of participants reported having experienced CCT. Path analyses with bootstrap confidence intervals demonstrated a relationship between CCT, psychoform (but not somatoform) dissociation, and cPTSD. In addition, psychoform dissociation partially mediated the relationship between CCT and adult cPTSD symptoms. Dissociation (pathological or nonpathological psychoform and somatoform symptoms) warrants further clinical and scientific study as a potential link between CCT and the presence of adult cPTSD symptoms and/or the dissociative subtype of PTSD.  
  Address a Yulius Academy & Colk Yulius , Rotterdam , The Netherlands  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1529-9732 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25905664 Approved no  
  Call Number UU @ jana.mullerova @ Serial 42187  
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Author Dorahy, M.J.; van der Hart, O. url  doi
openurl 
  Title DSM-5's posttraumatic stress disorder with dissociative symptoms: challenges and future directions Type Journal Article
  Year 2015 Publication Journal of Trauma & Dissociation : the Official Journal of the International Society for the Study of Dissociation (ISSD) Abbreviated Journal J Trauma Dissociation  
  Volume (down) 16 Issue 1 Pages 7-28  
  Keywords *Diagnostic and Statistical Manual of Mental Disorders; Dissociative Disorders/*classification; Humans; Stress Disorders, Post-Traumatic/*classification; Terminology as Topic; dissociation; dissociative subtype of posttraumatic stress disorder; positive and negative dissociative symptoms; posttraumatic stress disorder  
  Abstract The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, formally recognizes a dissociative subtype of posttraumatic stress disorder (PTSD; PTSD with dissociative symptoms). This nomenclative move will boost empirical and theoretical efforts to further understand the links between dissociation, trauma, and PTSD. This article examines the empirical literature showing that patients with PTSD can be divided into 2 different groups based on their neurobiology, psychological symptom profile, history of exposure to early relational trauma, and depersonalization/derealization symptoms. It then explores the conceptual and empirical challenges of conceiving 1 of these types as reflecting a “dissociative” type of PTSD. First, this classification is based on the presence of a limited subset of dissociative symptoms (i.e., depersonalization, derealization). This sets aside an array of positive and negative psychoform and somatoform dissociative symptoms that may be related to PTSD. Second, empirical evidence suggests heightened dissociation in PTSD compared to many other disorders, indicating that dissociation is relevant to PTSD more broadly rather than simply to the so-called dissociative subtype. This article sets out important issues to be examined in the future study of dissociation in PTSD, which needs to be informed by solid conceptual understandings of dissociation.  
  Address a Department of Psychology , University of Canterbury , Christchurch , New Zealand  
  Corporate Author Thesis  
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  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1529-9732 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24983300 Approved no  
  Call Number UU @ jana.mullerova @ Serial 42200  
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Author Ashalakshmi, N.C.; Nag, K.S.C.; Karanth, K.P. doi  openurl
  Title Molecules support morphology: species status of South Indian populations of the widely distributed Hanuman langur Type Journal Article
  Year 2015 Publication Abbreviated Journal Conservation Genetics  
  Volume (down) 16 Issue 1 Pages 43-58  
  Keywords  
  Abstract The taxonomy of the Hanuman langur (Semnopithecus spp.), a widely distributed Asian colobine monkey, has been in a flux for a long time due to much disagreement between various classification schemes. However, results from a recent field-based morphological study were consistent with Hill’s (Ceylon J Sci 21:277–305, 1939) species level classification scheme. Here we tested the validity of S. hypoleucos and S. priam, the two South Indian species recognized by Hill. To this end, one mitochondrial and four nuclear markers were sequenced from over 72 non-invasive samples of Hanuman langurs and S. johnii collected from across India. The molecular data were subjected to various tree building methods. The nuclear data was also used in a Bayesian structure analysis and to determine the genealogical sorting index of each hypothesized species. Results from nuclear data suggest that the South Indian population of Hanuman langur consists of two units that correspond to the species recognized by Hill. However in the mitochondrial tree S. johnii and S. priam were polyphyletic probably due to retention of ancestral polymorphism and/or low levels of hybridization. Implications of these results on conservation of Hanuman langurs are also discussed.  
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  ISSN 1572-9737 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number CES @ dilipnaidu.gt @ Serial 42966  
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Author Ng, A.; Barker, N. url  openurl
  Title Ovary and fimbrial stem cells: biology, niche and cancer origins Type Journal Article
  Year 2015 Publication Abbreviated Journal Nat Rev Mol Cell Biol  
  Volume (down) 16 Issue 10 Pages 625-638  
  Keywords  
  Abstract The mammalian ovary is covered by a single-layered epithelium that undergoes rupture and remodelling following each ovulation. Although resident stem cells are presumed to be crucial for this cyclic regeneration, their identity and mode of action have been elusive. Surrogate stemness assays and in vivo fate-mapping studies using recently discovered stem cell markers have identified stem cell pools in the ovary and fimbria that ensure epithelial homeostasis. Recent findings provide insights into intrinsic mechanisms and local extrinsic cues that govern the function of ovarian and fimbrial stem cells. These discoveries have advanced our understanding of stem cell biology in the ovary and fimbria, and lay the foundations for evaluating the contribution of resident stem cells to the initiation and progression of human epithelial ovarian cancer.  
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  Notes Approved no  
  Call Number UofT @ ankit.sinha @ Serial 44935  
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Author Drerup, J.M.; Liu, Y.; Padron, A.S.; Murthy, K.; Hurez, V.; Zhang, B.; Curiel, T.J. url  openurl
  Title Immunotherapy for ovarian cancer Type Journal Article
  Year 2015 Publication Abbreviated Journal Curr Treat Options Oncol  
  Volume (down) 16 Issue 1 Pages 317  
  Keywords  
  Abstract OPINION STATEMENT: All work referenced herein relates to treatment of epithelial ovarian carcinomas, as their treatment differs from ovarian germ cell cancers and other rare ovarian cancers, the treatments of which are addressed elsewhere. Fallopian tube cancers and primary peritoneal adenocarcinomatosis are also generally treated as epithelial ovarian cancers. The standard of care initial treatment of advanced stage epithelial ovarian cancer is optimal debulking surgery as feasible plus chemotherapy with a platinum plus a taxane agent. If this front-line approach fails, as it too often the case, several FDA-approved agents are available for salvage therapy. However, because no second-line therapy for advanced-stage epithelial ovarian cancer is typically curative, we prefer referral to clinical trials as logistically feasible, even if it means referring patients outside our system. Immune therapy has a sound theoretical basis for treating carcinomas generally, and for treating ovarian cancer in particular. Advances in understanding the immunopathogenic basis of ovarian cancer, and the immunopathologic basis for prior failures of immunotherapy for it and other carcinomas promises to afford novel treatment approaches with potential for significant efficacy, and reduced toxicities compared with cytotoxic agents. Thus, referral to early phase immunotherapy trials for ovarian cancer patients that fail conventional treatment merits consideration.  
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  Notes Times cited: 10 Approved no  
  Call Number UofT @ ankit.sinha @ Serial 45091  
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Author Allegretti, A.S.; Hundemer, G.; Chorghade, R.; Cosgrove, K.; Bajwa, E.; Bhan, I. openurl 
  Title Perspectives of continuous renal replacement therapy in the intensive care unit: a paired survey study of patient, physician, and nurse views Type Journal Article
  Year 2015 Publication Abbreviated Journal BMC Nephrol  
  Volume (down) 16 Issue Pages 105  
  Keywords KRESCENT, jclub  
  Abstract BACKGROUND: Recent studies suggest discrepancies between patients and providers around perceptions of hemodialysis prognosis. Such data are lacking for continuous renal replacement therapy (CRRT). We aim to assess patient and provider understanding of outcomes around CRRT.
METHODS: From February 1 to August 31, 2013, a triad of (1) a patient on CRRT (or health care proxy [HCP]), (2) physician and (3) primary nurse from the intensive care unit (ICU) team were surveyed. Univariate chi-square and qualitative analysis techniques were used.
RESULTS: Ninety-six total participants (32 survey triads) were completed. Ninety one percent of patients/HCPs correctly identified that CRRT replaced the function of the kidneys. Six percent of patients/HCPs, 44 % of physicians, and 44 % of nurses identified rates of survival to hospital discharge that were consistent with published literature. Both physicians and nurses were more likely than patients/HCPs to assess survival consistently with published data (p = 0.001). Patients/HCPs were more likely to overestimate survival rates than physicians and nurses (p < 0.001). Thirty eight percent of patients/HCPs, 38 % of physicians, and 28 % of nurses identified rates of lifelong dialysis-dependence among surviving patients that were consistent with published literature.
CONCLUSIONS: There is mismatch between patients, HCPs, and providers around prognosis of CRRT. Patients/HCPs are more likely to overestimate chances of survival than physicians or nurses. Further intervention is needed to improve this knowledge gap.
 
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  Call Number UofT @ mathieu.lemaire @ Serial 46000  
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Author Sekar, S.; Karanth, K.P. doi  openurl
  Title Does size matter? Comparative population genetics of two butterflies with different wingspans Type Journal Article
  Year 2015 Publication Abbreviated Journal Organisms Diversity & Evolution  
  Volume (down) 15 Issue 3 Pages 567-575  
  Keywords  
  Abstract The dispersal ability of a species is central to its biology, affecting other processes like local adaptation, population and community dynamics, and genetic structure. Among the intrinsic, species-specific factors that affect dispersal ability in butterflies, wingspan was recently shown to explain a high amount of variance in dispersal ability. In this study, a comparative approach was adopted to test whether a difference in wingspan translates into a difference in population genetic structure. Two closely related butterfly species from subfamily Satyrinae, family Nymphalidae, which are similar with respect to all traits that affect dispersal ability except for wingspan, were studied. Melanitis leda (wingspan 60–80 mm) and Ypthima baldus (wingspan 30–40 mm) were collected from the same areas along the Western Ghats of southern India. Amplified fragment length polymorphisms were used to test whether the species with a higher wingspan (M. leda) exhibited a more homogenous population genetic structure, as compared to a species with a shorter wingspan (Y. baldus). In all analyses, Y. baldus exhibited greater degree of population genetic structuring. This study is one of the few adopting a comparative approach to establish the relationship between traits that affect dispersal ability and population genetic structure.  
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  Series Volume Series Issue Edition  
  ISSN 1618-1077 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number CES @ dilipnaidu.gt @ Serial 43064  
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Author Ignatchenko, V.; Ignatchenko, A.; Sinha, A.; Boutros, P.C.; Kislinger, T. url  openurl
  Title VennDIS: a JavaFX-based Venn and Euler diagram software to generate publication quality figures Type Journal Article
  Year 2015 Publication Abbreviated Journal Proteomics  
  Volume (down) 15 Issue 7 Pages 1239-1244  
  Keywords  
  Abstract Venn diagrams are graphical representations of the relationships among multiple sets of objects and are often used to illustrate similarities and differences among genomic and proteomic datasets. All currently existing tools for producing Venn diagrams evince one of two traits; they require expertise in specific statistical software packages (such as R), or lack the flexibility required to produce publication-quality figures. We describe a simple tool that addresses both shortcomings, Venn Diagram Interactive Software (VennDIS), a JavaFX-based solution for producing highly customizable, publication-quality Venn, and Euler diagrams of up to five sets. The strengths of VennDIS are its simple graphical user interface and its large array of customization options, including the ability to modify attributes such as font, style and position of the labels, background color, size of the circle/ellipse, and outline color. It is platform independent and provides real-time visualization of figure modifications. The created figures can be saved as XML files for future modification or exported as high-resolution images for direct use in publications.  
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  Notes Approved no  
  Call Number UofT @ ankit.sinha @ Serial 45271  
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