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Author Al-Nouri, Z.L.; Reese, J.A.; Terrell, D.R.; Vesely, S.K.; George, J.N. url  openurl
  Title Drug-induced thrombotic microangiopathy: a systematic review of published reports Type Journal Article
  Year 2015 Publication Abbreviated Journal Blood  
  Volume (down) 125 Issue 4 Pages 616-618  
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  Abstract Many patients with syndromes of thrombotic microangiopathy (TMA), including thrombotic thrombocytopenic purpura and hemolytic-uremic syndrome, have been reported to have a drug-induced etiology, and many different drugs have been suspected as a cause of TMA. We established criteria to assess the strength of evidence for a causal association of a drug with TMA and systematically searched for all published reports of drug-induced TMA. We identified 1569 articles: 604 were retrieved for review, 344 reported evaluable data for 586 individual patients, 43 reported evaluable data on 46 patient groups. Seventy-eight drugs were described; 22 had evidence supporting a definite causal association with TMA. Three drugs accounted for 61 of the 104 patient reports with definite evidence (quinine, 34; cyclosporine, 15; tacrolimus, 12). Twenty additional drugs had evidence supporting a probable association with TMA. These criteria and data can provide support for clinicians evaluating patients with suspected TMA.  
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  ISSN 0006-4971 ISBN Medium  
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  Notes Approved no  
  Call Number UofT @ mathieu.lemaire @ Serial 45847  
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Author Albers, J.; Danzer, C.; Rechsteiner, M.; Lehmann, H.; Brandt, L.P.; Hejhal, T.; Catalano, A.; Busenhart, P.; Gonçalves, A.F.; Brandt, S.; Bode, P.K.; Bode-Lesniewska, B.; Wild, P.J.; Frew, I.J. url  openurl
  Title A versatile modular vector system for rapid combinatorial mammalian genetics Type Journal Article
  Year 2015 Publication Abbreviated Journal J Clin Invest  
  Volume (down) 125 Issue 4 Pages 1603-1619  
  Keywords Animals; Apoptosis; Caspase 9; Cells, Cultured; Cloning, Molecular; Clustered Regularly Interspaced Short Palindromic Repeats; Doxycycline; Drug Resistance; Gene Deletion; Gene Knockdown Techniques; Genetic Vectors; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lentivirus; Mice; Mice, SCID; PTEN Phosphohydrolase; Recombination, Genetic; research support, non-u.s. gov’t; Retinoblastoma Protein; RNA, Small Interfering; Sarcoma, Experimental; Transduction, Genetic; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays; Cas9/CRIPSR; Journal club  
  Abstract Here, we describe the multiple lentiviral expression (MuLE) system that allows multiple genetic alterations to be introduced simultaneously into mammalian cells. We created a toolbox of MuLE vectors that constitute a flexible, modular system for the rapid engineering of complex polycistronic lentiviruses, allowing combinatorial gene overexpression, gene knockdown, Cre-mediated gene deletion, or CRISPR/Cas9-mediated (where CRISPR indicates clustered regularly interspaced short palindromic repeats) gene mutation, together with expression of fluorescent or enzymatic reporters for cellular assays and animal imaging. Examples of tumor engineering were used to illustrate the speed and versatility of performing combinatorial genetics using the MuLE system. By transducing cultured primary mouse cells with single MuLE lentiviruses, we engineered tumors containing up to 5 different genetic alterations, identified genetic dependencies of molecularly defined tumors, conducted genetic interaction screens, and induced the simultaneous CRISPR/Cas9-mediated knockout of 3 tumor-suppressor genes. Intramuscular injection of MuLE viruses expressing oncogenic H-RasG12V together with combinations of knockdowns of the tumor suppressors cyclin-dependent kinase inhibitor 2A (Cdkn2a), transformation-related protein 53 (Trp53), and phosphatase and tensin homolog (Pten) allowed the generation of 3 murine sarcoma models, demonstrating that genetically defined autochthonous tumors can be rapidly generated and quantitatively monitored via direct injection of polycistronic MuLE lentiviruses into mouse tissues. Together, our results demonstrate that the MuLE system provides genetic power for the systematic investigation of the molecular mechanisms that underlie human diseases.  
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  ISSN 0021-9738 ISBN Medium  
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  Call Number UofT @ mathieu.lemaire @ Serial 45848  
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Author Nash, W.P.; Boasso, A.M.; Steenkamp, M.M.; Larson, J.L.; Lubin, R.E.; Litz, B.T. url  doi
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  Title Posttraumatic stress in deployed Marines: prospective trajectories of early adaptation Type Journal Article
  Year 2015 Publication Journal of Abnormal Psychology Abbreviated Journal J Abnorm Psychol  
  Volume (down) 124 Issue 1 Pages 155-171  
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  Abstract We examined the course of PTSD symptoms in a cohort of U.S. Marines (N = 867) recruited for the Marine Resiliency Study (MRS) from a single infantry battalion that deployed as a unit for 7 months to Afghanistan during the peak of conflict there. Data were collected via structured interviews and self-report questionnaires 1 month prior to deployment and again at 1, 5, and 8 months postdeployment. Second-order growth mixture modeling was used to disaggregate symptom trajectories; multinomial logistic regression and relative weights analysis were used to assess the role of combat exposure, prior life span trauma, social support, peritraumatic dissociation, and avoidant coping as predictors of trajectory membership. Three trajectories best fit the data: a low-stable symptom course (79%), a new-onset PTSD symptoms course (13%), and a preexisting PTSD symptoms course (8%). Comparison in a separate MRS cohort with lower levels of combat exposure yielded similar results, except for the absence of a new-onset trajectory. In the main cohort, the modal trajectory was a low-stable symptoms course that included a small but clinically meaningful increase in symptoms from predeployment to 1 month postdeployment. We found no trajectory of recovery from more severe symptoms in either cohort, suggesting that the relative change in symptoms from predeployment to 1 month postdeployment might provide the best indicator of first-year course. The best predictors of trajectory membership were peritraumatic dissociation and avoidant coping, suggesting that changes in cognition, perception, and behavior following trauma might be particularly useful indicators of first-year outcomes.  
  Address VA Boston Healthcare System  
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  Language English Summary Language Original Title  
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  ISSN 0021-843X ISBN Medium  
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  Notes PMID:25419860 Approved no  
  Call Number UU @ jana.mullerova @ Serial 42197  
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Author Slik, J.W.F.; Arroyo-Rodríguez, V.; Aiba, S.-I.; Alvarez-Loayza, P.; Alves, L.F.; Ashton, P.; Balvanera, P.; Bastian, M.L.; Bellingham, P.J.; van den Berg, E.; Bernacci, L.; da Conceição Bispo, P.; Blanc, L.; Böhning-Gaese, K.; Boeckx, P.; Bongers, F.; Boyle, B.; Bradford, M.; Brearley, F.Q.; Breuer-Ndoundou Hockemba, M.; Bunyavejchewin, S.; Calderado Leal Matos, D.; Castillo-Santiago, M.; Catharino, E.L.M.; Chai, S.-L.; Chen, Y.; Colwell, R.K.; Chazdon, R.L.; Clark, C.; Clark, D.B.; Clark, D.A.; Culmsee, H.; Damas, K.; Dattaraja, H.S.; Dauby, G.; Davidar, P.; DeWalt, S.J.; Doucet, J.-L.; Duque, A.; Durigan, G.; Eichhorn, K.A.O.; Eisenlohr, P.V.; Eler, E.; Ewango, C.; Farwig, N.; Feeley, K.J.; Ferreira, L.; Field, R.; de Oliveira Filho, A.T.; Fletcher, C.; Forshed, O.; Franco, G.; Fredriksson, G.; Gillespie, T.; Gillet, J.-F.; Amarnath, G.; Griffith, D.M.; Grogan, J.; Gunatilleke, N.; Harris, D.; Harrison, R.; Hector, A.; Homeier, J.; Imai, N.; Itoh, A.; Jansen, P.A.; Joly, C.A.; de Jong, B.H.J.; Kartawinata, K.; Kearsley, E.; Kelly, D.L.; Kenfack, D.; Kessler, M.; Kitayama, K.; Kooyman, R.; Larney, E.; Laumonier, Y.; Laurance, S.; Laurance, W.F.; Lawes, M.J.; Amaral, I.L. do; Letcher, S.G.; Lindsell, J.; Lu, X.; Mansor, A.; Marjokorpi, A.; Martin, E.H.; Meilby, H.; Melo, F.P.L.; Metcalfe, D.J.; Medjibe, V.P.; Metzger, J.P.; Millet, J.; Mohandass, D.; Montero, J.C.; de Morisson Valeriano, M.; Mugerwa, B.; Nagamasu, H.; Nilus, R.; Ochoa-Gaona, S.; Onrizal; Page, N.; Parolin, P.; Parren, M.; Parthasarathy, N.; Paudel, E.; Permana, A.; Piedade, M.T.F.; Pitman, N.C.A.; Poorter, L.; Poulsen, A.D.; Poulsen, J.; Powers, J.; Prasad, R.C.; Puyravaud, J.-P.; Razafimahaimodison, J.-C.; Reitsma, J.; dos Santos, J.R.; Roberto Spironello, W.; Romero-Saltos, H.; Rovero, F.; Rozak, A.H.; Ruokolainen, K.; Rutishauser, E.; Saiter, F.; Saner, P.; Santos, B.A.; Santos, F.; Sarker, S.K.; Satdichanh, M.; Schmitt, C.B.; Schöngart, J.; Schulze, M.; Suganuma, M.S.; Sheil, D.; da Silva Pinheiro, E.; Sist, P.; Stevart, T.; Sukumar, R.; Sun, I.-F.; Sunderland, T.; Suresh, H.S.; Suzuki, E.; Tabarelli, M.; Tang, J.; Targhetta, N.; Theilade, I.; Thomas, D.W.; Tchouto, P.; Hurtado, J.; Valencia, R.; van Valkenburg, J.L.C.H.; Van Do, T.; Vasquez, R.; Verbeeck, H.; Adekunle, V.; Vieira, S.A.; Webb, C.O.; Whitfeld, T.; Wich, S.A.; Williams, J.; Wittmann, F.; Wöll, H.; Yang, X.; Adou Yao, C.Y.; Yap, S.L.; Yoneda, T.; Zahawi, R.A.; Zakaria, R.; Zang, R.; de Assis, R.L.; Garcia Luize, B.; Venticinque, E.M. url  openurl
  Title An estimate of the number of tropical tree species Type Journal Article
  Year 2015 Publication Abbreviated Journal Proceedings of the National Academy of Sciences  
  Volume (down) 112 Issue 24 Pages 7472-7477  
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  Abstract The high species richness of tropical forests has long been recognized, yet there remains substantial uncertainty regarding the actual number of tropical tree species. Using a pantropical tree inventory database from closed canopy forests, consisting of 657,630 trees belonging to 11,371 species, we use a fitted value of Fisher’s alpha and an approximate pantropical stem total to estimate the minimum number of tropical forest tree species to fall between ∼40,000 and ∼53,000, i.e., at the high end of previous estimates. Contrary to common assumption, the Indo-Pacific region was found to be as species-rich as the Neotropics, with both regions having a minimum of ∼19,000–25,000 tree species. Continental Africa is relatively depauperate with a minimum of ∼4,500–6,000 tree species. Very few species are shared among the African, American, and the Indo-Pacific regions. We provide a methodological framework for estimating species richness in trees that may help refine species richness estimates of tree-dependent taxa.  
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  Call Number CES @ dilipnaidu.gt @ Serial 43105  
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Author Borges, R.M. openurl 
  Title How mutualisms between plants and insects are stabilized Type Journal Article
  Year 2015 Publication Abbreviated Journal Current Science  
  Volume (down) 108 Issue 10 Pages 1862-1868  
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  Call Number CES @ dilipnaidu.gt @ Serial 43028  
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Author Gadagkar, R. openurl 
  Title How should biologists engage with controversial mathematical theory? Type Journal Article
  Year 2015 Publication Abbreviated Journal Current Science  
  Volume (down) 108 Issue 10 Pages 1869-1873  
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  Call Number CES @ dilipnaidu.gt @ Serial 43034  
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Author Karanth, P.K. openurl 
  Title An island called India: phylogenetic patterns across multiple taxonomic groups reveal endemic radiations Type Journal Article
  Year 2015 Publication Abbreviated Journal Current Science  
  Volume (down) 108 Issue 10 Pages 1847-1851  
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  Call Number CES @ dilipnaidu.gt @ Serial 43063  
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Author Labiak, P. H.; Sundue, M. A.; Rouhan, G.; Moran, R. C. doi  openurl
  Title Rhopalotricha, a New Subgenus of the Fern Genus Lastreopsis (Dryopteridaceae) Type Journal Article
  Year 2015 Publication American Fern Journal Abbreviated Journal  
  Volume (down) 105 Issue 1 Pages 20-30  
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  Abstract A new subgenus of Lastreopsis, subg. Rhopalotricha, is here described based on the results of our recent phylogenetic analyses. Its species differ from others in the genus by having a distinctive type of hair within the grooves of the rachises and costae adaxially. These are 1–3(–4)-celled and clavate, whereas the remainders of the species in the genus have hairs that are 3–12-celled and non-clavate. Subgenus Rhopalotricha also differs by having spores with broadly folded perispores with echinulate surfaces (vs. tuberculate or spiny, and with smooth surfaces). Subgenus Rhopalotricha occurs in the Neotropics, islands of the southwestern Pacific (Samoa, Fiji, and Vanuatu), New Zealand, and Australia. A key is provided to distinguish the species, each of which is treated with synonymy, description, geographic distribution by country, elevation ranges, and discussions. Lectotypes are also designated for Dryopteris amplissima var. subeffusa, Aspidium macrum Fée, and Aspidium latissimum Fée.  
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  Call Number NYBG @ sthackurdeen @ Serial 42430  
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Author Gulbahar, O.; Konca Degertekin, C.; Akturk, M.; Yalcin, M.M.; Kalan, I.; Atikeler, G.F.; Altinova, A.E.; Yetkin, I.; Arslan, M.; Toruner, F. url  doi
openurl 
  Title A Case With Immunoassay Interferences in the Measurement of Multiple Hormones Type Journal Article
  Year 2015 Publication The Journal of Clinical Endocrinology and Metabolism Abbreviated Journal J Clin Endocrinol Metab  
  Volume (down) 100 Issue 6 Pages 2147-2153  
  Keywords Adult; Antibodies, Heterophile/*blood; *Artifacts; Cross Reactions; *Diagnostic Techniques, Endocrine/standards; False Positive Reactions; Female; Hormones/*analysis; Humans; Immunoassay/methods; Postpartum Period/blood/immunology  
  Abstract CONTEXT: Commonly used immunoassays are not free from interference, which can be a confounder in the interpretation of test results. We present a case with extremely high multiple hormone levels due to such interference. CASE DESCRIPTION: A 33-year-old woman with no specific symptoms had markedly elevated TSH with normal free T4 and free T3 levels. Repeated measurements revealed discordantly high TSH, ACTH, FSH, PTH, IGF-1, prolactin, beta-human chorionic gonadotropin, and calcitonin levels without the associated clinical pictures. The measurements were repeated with the same patient sample on four different analytical platforms using chemiluminescence immunoassays/electrochemiluminescence immunoassays, and the results were divergent on each platform. Serial dilutions of serum samples revealed nonlinearity, suggesting assay interference. All hormonal measurements were in the normal range when heterophile antibody blocking tubes were used. The serum of the patient was then subjected to polyethylene glycol precipitation. The post-polyethylene glycol recovery resulted in hormone levels in the normal range. The patient did not receive any medications and has been under follow-up without any signs and symptoms for 24 months. CONCLUSIONS: This report illustrates a rare case of falsely elevated hormone levels due to assay interference caused by heterophile antibodies. We point out the importance of a close collaboration between clinicians and the laboratory to avoid unnecessary clinical investigations as well as inappropriate treatments.  
  Address Departments of Biochemistry (O.G., G.F.A.) and Endocrinology and Metabolism (C.K.D., M.A., M.M.Y., I.K., A.E.A., I.Y., M.A., F.T.), Gazi University Faculty of Medicine, 06100 Ankara, Turkey  
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  ISSN 0021-972X ISBN Medium  
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  Notes PMID:25897621 Approved no  
  Call Number QEHB @ isla.wootton @ Serial 42160  
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Author Borges, R.M. openurl 
  Title Fruit and Seed Volatiles: Multiple Stage Settings, Actors and Props in an Evolutionary Play Type Journal Article
  Year 2015 Publication Abbreviated Journal Journal of the Indian Institute of Science  
  Volume (down) 95 Issue 1 Pages 93-104  
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  ISSN 0970-4140 ISBN Medium  
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  Notes Approved no  
  Call Number CES @ dilipnaidu.gt @ Serial 43137  
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