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(2019). Journal club. Kidney International, 95(1), 11–13.
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Abudurexiti, A., Adkins, S., Alioto, D., Alkhovsky, S. V., Avsic-Zupanc, T., Ballinger, M. J., et al. (2019). Taxonomy of the order Bunyavirales: update 2019. Arch Virol, 164(7), 1949–1965.
Abstract: In February 2019, following the annual taxon ratification vote, the order Bunyavirales was amended by creation of two new families, four new subfamilies, 11 new genera and 77 new species, merging of two species, and deletion of one species. This article presents the updated taxonomy of the order Bunyavirales now accepted by the International Committee on Taxonomy of Viruses (ICTV).
Keywords: Bunyaviridae/*classification/*genetics; Genome, Viral/genetics; Phylogeny; RNA, Viral/genetics
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Bandera, A., Gori, A., Clerici, M., & Sironi, M. (2019). Phylogenies in ART: HIV reservoirs, HIV latency and drug resistance. Curr Opin Pharmacol, 48, 24–32.
Abstract: Combination antiretroviral therapy (ART) has significantly reduced the morbidity and mortality resulting from HIV infection. ART is, however, unable to eradicate HIV, which persists latently in several cell types and tissues. Phylogenetic analyses suggested that the proliferation of cells infected before ART initiation is mainly responsible for residual viremia, although controversy still exists. Conversely, it is widely accepted that drug resistance mutations (DRMs) do not appear during ART in patients with suppressed viral loads. Studies based on sequence clustering have in fact indicated that, at least in developed countries, HIV-infected ART-naive patients are the major source of drug-resistant viruses. Analysis of longitudinally sampled sequences have also shown that DRMs have variable fitness costs, which are strongly influenced by the viral genetic background.
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Branton, A., Trivedi, M. K., Trivedi, D., Nayak, G., & Jana, S. (2019). Characterization of the Physicochemical and Thermal properties of the Biofield Energy Treated Flutamide Using PSA, PXRD, TGA/DTG, and DSC Analytical Techniques. Journal of Complementary Medicine and Alternative Healthcare, 8(5). Retrieved August 15, 2020, from http://dx.doi.org/10.19080/JCMAH.2019.08.555748
Abstract: Flutamide is an antiandrogen drug that blocks the action of testosterone by binding to the androgen receptor. This study was designed to determine the impact of the Trivedi Effect®-Energy of Consciousness Healing Treatment on the physicochemical and thermal properties of flutamide. The test sample was divided into two parts, i.e., control and treated sample. The control part was known as untreated sample, while the treated part remotely received the Biofield Energy Healing Treatment by a renowned Biofield Energy Healer, Alice Branton. The study showed that the particle size values were significantly increased by 15.82%(d10), 16.36%(d50), 1.05%(d90), and 5.10% {D (4, 3)}; thus, the specific surface area was significantly decreased by 14.56% in the treated sample compared with the control sample. The PXRD peak intensities and crystallite sizes were significantly altered ranging from 7.02% to 29.41% and -9.17% to 17.86%, along with 2.84% increase in the average crystallite size in the treated flutamide compared to the control sample. The residue weight was significantly decreased by 64.16%; however, the maximum thermal degradation temperature was increased by 10.16% in the treated sample compared to the control sample. The latent heat of the treated sample reduced by 9.37% compared with the control sample. The results revealed the significant alteration in the crystallinity, particle size and thermal stability of the treated sample as compared to the untreated sample. Thus, the Biofield Energy Treated flutamide might improve the flowability, and compatibility compared with the untreated sample, that may help in designing a better pharmaceutical formulation in terms of its performance against various diseases.
Keywords: Flutamide; The Trivedi Effect®; Energy of consciousness haling treatment; Complementary and alternative medicine; PSA; PXRD; TGA; DSC
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Branton, A., Trivedi, M. K., Trivedi, D., Nayak, G., & Jana, S. (2019). Solid State Characterization for a Comparative Evaluation of the Biofield Energy Treated and Un-treated Ascorbic Acid. Drug Designing & Intellectual Properties International Journal, 2(5). Retrieved August 15, 2020, from http://dx.doi.org/10.32474/DDIPIJ.2019.02.000149
Abstract: Ascorbic acid is a water-soluble vitamin that mainly acts as an antioxidant and helps in controlling and maintaining various body functions. The study was designed to analyze the impact of the Trivedi Effect®-Consciousness Energy Healing Treatment on the physicochemical and thermal properties of ascorbic acid by using sophisticated analytical techniques. For the study, the test sample ascorbic acid was divided into the control and treated sample. To the control sample, no Biofield Energy Treatment was provided. However, the treated sample received the Biofield Energy Treatment remotely by the renowned Biofield Energy Healer, Alice Branton, USA. The PXRD peak intensities and crystallite sizes of the treated sample significantly altered ranging from -78.43% to 1168.06% and -62.38% to 126.83%, respectively; along with 24.99% decrease in the average crystallite size as compared to the control sample. The particle size values in the treated sample by 9.59% (d10), 21.63% (d50), 16.55% (d90), and 17.97% {D(4,3)}, respectively; hence the specific surface area was increased by 16.67% compared to the control sample. The weight loss was increased by 6.67%; however, the residue amount was found to be significantly decreased by 28.59% in the treated sample compared to the control sample. The Tmax of the treated sample corresponding to 1st and 2nd peaks were decreased by 0.33% and 4.09%, respectively as compared to the control sample. Moreover, the latent heat of fusion was significantly increased by 13.74% as compared to the control sample. Besides, the degradation temperature and ΔHdecomposition of the treated sample were significantly reduced by 6.54% and 20.46%, respectively, as compared to the control sample. The Trivedi Effect® might help in forming a novel polymorphic form of ascorbic acid that may also prove to be more soluble, absorbable, and bioavailable than the untreated sample. Thus, the Trivedi Effect® might be considered as a novel approach for designing the more efficacious ascorbic acid containing nutraceutical/pharmaceutical formulations.
Keywords: Ascorbic acid; Consciousness Energy Healing Treatment; The Trivedi Effect®; PXRD; Particle size; TGA/DTG
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Branton, A., Trivedi, M. K., Trivedi, D., Nayak, G., & Jana, S. (2019). Study of the Effect of Consciousness Energy Healing Treatment on the Natural Product Berberine Chloride. International Journal of Pharmacognosy and Chinese Medicine, 3(1). Retrieved August 15, 2020, from http://dx.doi.org/10.23880/ipcm-16000154
Abstract: Berberine chloride is an isoquinoline alkaloid that has antimicrobial activity against bacteria, viruses, chlamydia, fungi, protozoans, and helminths, etc. The study was designed with the aim to evaluate the influence of the Trivedi Effect®- Consciousness Energy Healing Treatment on the physicochemical and thermal properties of berberine chloride by using modern analytical techniques. For this study, the berberine chloride sample was divided into two parts among which, one part was named as control as no Biofield Energy Treatment was given to it; while the other part received the Consciousness Energy Healing Treatment remotely by a renowned Biofield Energy Healer, Alice Branton and named as the Biofield Energy Treated sample. The PXRD results revealed some changes in the Bragg’s angle of peaks along with -7.24% to 188.78% alterations in the peak intensities and -65.88% to 135.42% changes in the crystallite sizes of the treated sample. Also, there was 1.91% decrease in the average crystallite size of the treated sample compared to the control sample. The particle size of the treated sample was significantly reduced by 20.16% (d10), 17.21% (d50), 27.53% (d90), and 27.36% {D(4,3)}; along with 15.31% increase in the specific surface area compared with the control sample. The total weight loss was significantly reduced by 25.81%; however, the residue amount was significantly increased by 55.04% in the treated sample compared to the control sample. Besides, the DSC thermogram showed four peaks, in which the peak temperatures of the treated sample corresponding to 1st, 2nd, 3rd, and 4th peak were altered by -2.26%, 3.55%, -4.50%, and -0.69%, respectively. Moreover, the latent heat for 1st, 2nd, 3rd, and 4th peak of the treated sample were significantly reduced by 24.04%, 42.44%, 44.26%, and 47.78%, respectively, compared with the control sample. The results showed that the Trivedi Effect®-Consciousness Energy Healing Treatment might help in improving the solubility, absorption, and bioavailability of berberine chloride compared with the control sample. Hence, the Consciousness Energy Healing Treatment would be useful for designing the novel nutraceutical/pharmaceutical formulations of berberine chloride with improved drug profile for the treatment of various microbial diseases and disorders such as diarrhea, gastroenteritis, hypertension, tumor, malaria, hyperglycemia, inflammation, arrhythmia, infections, etc.
Keywords: Berberine Chloride; Consciousness Energy Healing Treatment; Complementary and Alternative Medicine; The Trivedi Effect®; PXRD; Particle Size; TGA/DTG; DSC
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Cagliani, R., Forni, D., & Sironi, M. (2019). Mode and tempo of human hepatitis virus evolution. Comput Struct Biotechnol J, 17, 1384–1395.
Abstract: Human viral hepatitis, a major cause of morbidity and mortality worldwide, is caused by highly diverse viruses with different genetic, ecological, and pathogenetic features. Technological advances that allow throughput sequencing of viral genomes, as well as the development of computational tools to analyze such genome data, have largely expanded our knowledge on the host range and evolutionary history of human hepatitis viruses. Thus, with the exclusion of hepatitis D virus, close or distant relatives of these human pathogens were identified in a number of domestic and wild mammals. Also, sequences of human viral strains isolated from different geographic locations and over different time-spans have allowed the application of phylogeographic and molecular dating approaches to large viral phylogenies. In this review, we summarize the most recent insights into our understanding of the evolutionary events and ecological contexts that determined the origin and spread of human hepatitis viruses.
Keywords: Host switch; Human hepatitis virus; Molecular dating; NHP, non-human primates; ORF, open reading frame; RdRp, RNA-dependent RNA polymerase; STI, sexually transmitted infection; TDRP, time-dependent rate phenomenon; TMRCA, time to the most recent common ancestor; Zoonosis
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Maes, P., Adkins, S., Alkhovsky, S. V., Avsic-Zupanc, T., Ballinger, M. J., Bente, D. A., et al. (2019). Taxonomy of the order Bunyavirales: second update 2018. Arch Virol, 164(3), 927–941.
Abstract: In October 2018, the order Bunyavirales was amended by inclusion of the family Arenaviridae, abolishment of three families, creation of three new families, 19 new genera, and 14 new species, and renaming of three genera and 22 species. This article presents the updated taxonomy of the order Bunyavirales as now accepted by the International Committee on Taxonomy of Viruses (ICTV).
Keywords: Animals; Arenaviridae/*classification/genetics/isolation & purification; Arenaviridae Infections/virology; Humans; Phylogeny
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Naseem Abbas Ahmar. (2019). Intaqad e Urdu Fiction (Vol. 1). Faisalabad: Misal Publishers.
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Naseem Abbas Ahmar. (2019). Nau -Tareekhiat (Vol. 1). Faisalabad: Misal publishers.
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