Abstract: Flutamide is an antiandrogen drug that blocks the action of testosterone by binding to the androgen receptor. This study was designed to determine the impact of the Trivedi Effect®-Energy of Consciousness Healing Treatment on the physicochemical and thermal properties of flutamide. The test sample was divided into two parts, i.e., control and treated sample. The control part was known as untreated sample, while the treated part remotely received the Biofield Energy Healing Treatment by a renowned Biofield Energy Healer, Alice Branton. The study showed that the particle size values were significantly increased by 15.82%(d10), 16.36%(d50), 1.05%(d90), and 5.10% {D (4, 3)}; thus, the specific surface area was significantly decreased by 14.56% in the treated sample compared with the control sample. The PXRD peak intensities and crystallite sizes were significantly altered ranging from 7.02% to 29.41% and -9.17% to 17.86%, along with 2.84% increase in the average crystallite size in the treated flutamide compared to the control sample. The residue weight was significantly decreased by 64.16%; however, the maximum thermal degradation temperature was increased by 10.16% in the treated sample compared to the control sample. The latent heat of the treated sample reduced by 9.37% compared with the control sample. The results revealed the significant alteration in the crystallinity, particle size and thermal stability of the treated sample as compared to the untreated sample. Thus, the Biofield Energy Treated flutamide might improve the flowability, and compatibility compared with the untreated sample, that may help in designing a better pharmaceutical formulation in terms of its performance against various diseases.

Abstract: Berberine chloride is an isoquinoline alkaloid that has antimicrobial activity against bacteria, viruses, chlamydia, fungi, protozoans, and helminths, etc. The study was designed with the aim to evaluate the influence of the Trivedi Effect®- Consciousness Energy Healing Treatment on the physicochemical and thermal properties of berberine chloride by using modern analytical techniques. For this study, the berberine chloride sample was divided into two parts among which, one part was named as control as no Biofield Energy Treatment was given to it; while the other part received the Consciousness Energy Healing Treatment remotely by a renowned Biofield Energy Healer, Alice Branton and named as the Biofield Energy Treated sample. The PXRD results revealed some changes in the Bragg’s angle of peaks along with -7.24% to 188.78% alterations in the peak intensities and -65.88% to 135.42% changes in the crystallite sizes of the treated sample. Also, there was 1.91% decrease in the average crystallite size of the treated sample compared to the control sample. The particle size of the treated sample was significantly reduced by 20.16% (d10), 17.21% (d50), 27.53% (d90), and 27.36% {D(4,3)}; along with 15.31% increase in the specific surface area compared with the control sample. The total weight loss was significantly reduced by 25.81%; however, the residue amount was significantly increased by 55.04% in the treated sample compared to the control sample. Besides, the DSC thermogram showed four peaks, in which the peak temperatures of the treated sample corresponding to 1st, 2nd, 3rd, and 4th peak were altered by -2.26%, 3.55%, -4.50%, and -0.69%, respectively. Moreover, the latent heat for 1st, 2nd, 3rd, and 4th peak of the treated sample were significantly reduced by 24.04%, 42.44%, 44.26%, and 47.78%, respectively, compared with the control sample. The results showed that the Trivedi Effect®-Consciousness Energy Healing Treatment might help in improving the solubility, absorption, and bioavailability of berberine chloride compared with the control sample. Hence, the Consciousness Energy Healing Treatment would be useful for designing the novel nutraceutical/pharmaceutical formulations of berberine chloride with improved drug profile for the treatment of various microbial diseases and disorders such as diarrhea, gastroenteritis, hypertension, tumor, malaria, hyperglycemia, inflammation, arrhythmia, infections, etc.

Abstract: Mercaptopurine is an antineoplastic chemotherapy drug is used for the treatment of cancer, Crohn's disease, ulcerative colitis, autoimmune diseases, etc. In this scientific study, the impact of the Trivedi Effect®-Consciousness Energy Healing Treatment on the physicochemical and thermal properties of 6-mercaptopurine was evaluated using the modern analytical technique. The test sample 6-Mercaptopurine powder was divided and named into control and treated sample. The control sample did not receive the Biofield Energy Treatment; whereas, the treated sample received the Biofield Energy Treatment remotely by a well-known Biofield Energy Healer, Gopal Nayak. The particle size values in the treated 6-mercaptopurine sample were significantly decreased by 10.18% (d10), 10.59% (d50), 7.62% (d90), and 9.17% {D(4,3)}; thus, the specific surface area was significantly increased by 10.28% compared to the control sample. The powder XRD peak intensities and crystallite sizes of the treated 6-mercaptopurine were significantly altered ranging from -43.40% to 23.33% and -37.09% to 136.67%, respectively; whereas the average crystallite size was significantly decreased by 11.04% compared with the control sample. The latent heat of evaporation and latent heat of fusion of the treated 6-mercaptopurine were significantly increased by 11.81% and 14.97% compared with the control sample. The total residue amount was significantly increased by 6.44% in the treated sample compared with the control sample. The maximum thermal degradation temperature of the 1st, 2nd, and 3rd peaks of the treated sample was altered by 1.55%, 0.18%, and -1.29% compared with the control sample. It was concluded that the Trivedi Effect®-Consciousness Energy Healing Treatment might have generated a new polymorphic form of 6-mercaptopurine which would offer better solubility, absorption, and bioavailability compared with the control sample. The Biofield Energy Treated 6-mercaptopurine would be more efficacious against acute lymphocytic leukemia, chronic myeloid leukemia, Crohn's disease, ulcerative colitis, and autoimmune diseases.

Abstract: The aim of the present research investigation was to monitor the effect of Consciousness Energy Healing based DMEM medium in a synovial sarcoma cell line (SW982) for evaluation of bone health (anti-rheumatoid arthritis) potential using inflammatory parameter interleukin-8 (IL-8). The test item (DMEM) was divided into two parts. One part was represented as the untreated test item without any Biofield Energy Treatment, while the other portion was defined as the Biofield Energy Treated test item, which received the Biofield Energy Healing Treatment by a renowned Biofield Energy Healer, Dahryn Trivedi. MTT assay was used for testing the cell viability and the results showed that the cell viability of SW982 cells was more than 100% with a safe and non-toxic profile. Further, the test item showed a significant (p≤0.001) inhibition of IL-8 secretion by 70.05% under the stimulation of IL-1β in SW982 cells as compared to the untreated DMEM group. Overall, the experimental data revealed the significant potential of the test item against rheumatoid arthritis to reduce inflammation in joints. Thus, it is concluded that Consciousness Energy Healing Treatment significantly inhibits the pro-inflammatory cytokine (IL-8), which showed a potential to act as an anti-rheumatic action in arthritis and other bone inflammatory disorders such as osteoporosis, Paget’s disease of bone, rickets, deformed bones, osteomalacia, osteoma, aging, bone loss, and fractures.

Abstract: L-tryptophan is an essential amino acid that needs to be supplemented through protein-rich diet and it helps in growth and nitrogen balance in the humans. The aim of this study is to evaluate the effect of the Trivedi Effect®-Consciousness Energy Healing Treatment on the L-tryptophan in terms of its physicochemical and thermal properties by using modern analytical techniques. The method involved dividing the test sample into two parts and providing the Consciousness Energy Healing Treatment to one part (named as Biofield Energy Treated sample), remotely by a renowned Biofield Energy Healer, Dahryn Trivedi; while the other part didn’t receive any treatment called a control sample. The particle size values of the treated sample was increased by 4.77% (d10), 6.37% (d50), 6.72% (d90), and 6.49% {D(4,3)}; thus, the specific surface area was increased by 4.35% compared to the control sample. The PXRD peak intensities and crystal-lite sizes of the treated sample were significantly altered ranging from -82.69% to 30.54% and -17.15% to 179.73%, respectively, in comparison to the control sample. The total weight loss of the treated sample was significantly reduced by 11.60% during the heating process that resulted in a significant increase in the residual amount of the sample by 1093.33% as compared to the control sample. The melting temperature and the latent heat of fusion of the treated sample were significantly increased by 1.12% and 6.79%, respectively, compared to the untreated sample. Hence, the L-tryptophan might form a new polymorph after the Trivedi Effect®-Consciousness Energy Healing Treatment that may possess better solubility and bioavailability profile along with improved thermal stability compared with the untreated sample. Thus, the Trivedi Effect®-Consciousness Energy Healing Treatment could be considered as a novel approach for designing the formulations with improved drug profile and efficacy. The treated L-tryptophan would be more useful for the treatment of mental health disorders, premenstrual dysphoric disorder (PMDD), attention deficit-hyperactivity disorder (ADHD), obsessive-compulsive disorder, depression, and bipolar disorder, etc.